Posts Tagged curcumin

“Restless Legs Syndrome More Prevalent Among Hemodialysis Patients, Correlates With CRP (Inflammation) Levels” by Daniel M. Keller, PhD, Medscape

Woman trying to sleepThis article is based on a lecture from the XLVII European Renal Association-European Dialysis and Transplant Association Congress.

Giulio Romano, MD, professor of nephrology at the University of Udine in Italy, told Medscape Medical News that “the interesting conclusion of our work is that there is a correlation between Restless Legs Syndrome and an increase of inflammatory cytokines and the increase of CRP (inflammation biomarker).”

Dr. Romano noted that several studies have shown that increased inflammation is associated with elevated cardiovascular risk in patients on chronic hemodialysis. Also, he said there is evidence that sleep disorders induce elevated levels of proinflammatory cytokines.

“We think that if patients have some sleep disorders, they evoke inflammation,” he said; “if we treat the sleep disorders, we reduce a cardiovascular risk factor because CRP is a possible cause of increased cardiovascular risk.” The hemodialysis patients without RLS, he noted, had much lower CRP levels. Similarly, the levels of transferrin saturation, another marker of inflammation, were different between patients with and without RLS.

0Nageswara Reddy, MD, assistant professor of nephrology at Manipal University in India, who was not involved with the study, told Medscape Medical News that it makes sense to him that RLS is associated with inflammatory markers. Cardiovascular mortality, which is the main cause of death among hemodialysis patients, is associated with elevated levels of CRP, but it might be associated with other underlying causes as well.

“We have to find out all risk factors. Maybe lack of sleep is another risk factor,” Dr. Reddy hypothesized, and suggested that other inflammatory markers, in addition to CRP, be investigated.

You can read the full article here:
http://www.medscape.com/viewarticle/724535

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I’ve Been Banned from RLS.org For Good

ban-youre-banned1All this crazy talk about non medical cures for RLS has got me banned from RLS.org again. This time I suspect for good.

It really is a crime that an organization that gathers people together in a unified search for a solution, would ban someone that offers proof that there are solutions.

They are so tightly bound to the pharmaceutical industry, it’s frightening.

I realize that they’re no different than any other foundation, it’s just that I’m seeing one up close for the first time.

I’m mostly frustrated because they’re misleading thousands of people, saying that their only chance at relief is through medication.

These are people that trust that they are being told the truth, and they’re not.

They’re being horribly misled.

 

 

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Why CAN’T There be a Cure for Restless Legs Syndrome?

41Q8V569JEL._SS500____jpg_336x360_q85THE NOETIC SCIENCES SPONTANEOUS REMISSION PROJECT

Hopefully those of you that are stuck in a deep, seemingly hopeless pit with your RLS, can draw some inspiration from this study.

In 1993, the Institute of Noetic Sciences published “Spontaneous Remission: An Annotated Bibliography.”

In this work, the authors defined spontaneous remission as “the disappearance, complete or incomplete, of a disease or cancer without medical treatment or treatment that is considered inadequate to produce the resulting disappearance of disease symptoms or tumor.”

From their website:
http://www.noetic.org/research/project/spontaneous-remission

“The Remission Project catalogued the world’s medical literature on the subject and the resulting book was the largest database of MEDICALLY REPORTED cases of spontaneous remission in the world, with more than 3,500 references from more than 800 journals in 20 different languages.

An example of “pure remission” would be a patient diagnosed with bone cancer, who refused treatment and who is disease-free more than 10 years later (so we’re not talking about the placebo effect).

Spontaneous remission of cancer has been reported in almost every type of cancer. The largest number of cases are reported in a few types of cancer: neuroblastoma, renal cell carcinoma, melanoma, and leukemias/lymphomas comprise the largest number of cases reported.

Psychological and spiritual factors play a role in remission and survival is evident from the stories of people who have experienced unexplained recoveries from cancer and other diseases, but since the role of mind and the spirit is different for each person, it is difficult to generalize their influence.”

SO, WHAT DOES THIS HAVE TO DO WITH RESTLESS LEGS SYNDROME?Close up of two feet in a bed

Even though there is “no cure” for cancer, thousands of people over the years have beat the disease.

And there is no set way to this “cure.” There’s no pattern. They all had to do it in a way that WORKED FOR THEM.

Through a combination of a focused determination, perseverance, courage, changes in diet, beliefs & attitudes, physical exercise, meditation, prayer etc. they beat an unbeatable disease.

They overcame their cancer by creating a cure through trial and error, based on their own life experience, using the successes of others as a “guideline.”
 
feeling-hormonal-yl-de“THERE IS NO CURE FOR RESTLESS LEGS SYNDROME!!!!!!

Yes, I’ve heard it a million times.

For several years now I’ve posted on RLS community boards information that I believe would be helpful to those that are suffering.

The most common reaction I get is that there is “NO CURE FOR RLS!” (followed by YOU QUACK, YOU FRAUD, YOU DISGUSTING EVIL PERSON etc.).

In fact the reaction is so strong I’ve been banned for good from RLS.uk. And on top of that, no current member is even allowed to reference me or my website.

I was banned from both RLS.org and RLS.org.au but was allowed back to both. I know I’m currently on thin ice on one of them. I’m on thin ice, and I censor myself so intensely it’s embarrassing, just to avoid getting the boot again.

One nutcase that runs a Yahoo RLS group notified the FDA about me.

All because I claim there is a cure.

I guess if you can invoke that type of reaction you must be doing something right?

It is criminal that these so called “moderators” screen out the information just because they disagree with it – information that the new or casual observer is unable to read and decide for his or herself whether or not they would like to follow up on it.

I understand that in their minds, the moderators are protecting their flock, but the truth is they have serious control issues  that are condemning their members to “life on meds” – continually brainwashing them with the idea that THERE IS NO CURE.

“Stay on your meds and wait with the rest of us for a cure!”

That’s the message.

THE DEFINITION OF INCURABLEsad-women06

Here is the definition of Incurable from Dictionary.com

adjective

1. not curable; that cannot be cured, remedied, or corrected:
an incurable disease.

2. not susceptible to change.

So, by definition, since I had RLS and no longer have it (and many others as well) that means RLS is actually NOT incurable. It is then by definition, curable.

bad-doctorWHY ARE ALL THE SUCCESS STORIES IGNORED?

There are hundreds, probably thousands of people that suffered from RLS, and because of changes in their life, no longer do.

Yet the most common response I get to my claim is not “what did you do to break free, for God’s sake, please tell me!”

The most common response is “you didn’t really have it” or even better “you’re just making this all up!”

It sounds like a really bad parent, doesn’t it?

Of course the claim of these hardliners (and there are many of them) is that their RLS is REALLY REALLY REALLY BAD … something the average sufferer couldn’t even imagine, or endure. 

It’s only the people with mild or pretend RLS that get better.

It’s the heroic ones that still suffer with the “TRUE” RLS.

PEOPLE TAKE IT PERSONALLYpunching

When I post something that hints that there is a cure for RLS, people start freaking at me, interpreting my post as an attack on their character.

They feel that I’m telling them that because they are on meds, they are weak.

Nothing could be further from the truth.

The reason I post the information is so that people who are trapped in a living Hell can “consider” alternatives. I’m only trying to let them know that there are options.

If you escaped from something that was inescapable, would you not try to help others who are still trapped?

It’s human nature.

The whole foundation of self-help groups is based upon this principle.

Drawing up a retirement savings planYOU CAN STAY ON MEDS AND DEVELOP A PLAN OF ACTION

My wife Barb developed a three year multi-stage plan to quit smoking. I had to respect that. That’s what SHE needed to do in order to quit. She developed a plan of action based on HER life experience and HER character and set it in motion.

And it worked. At the end of the process she stopped smoking. She hasn’t had a cigarette in eight years.

However, if she was to push her method on a friend who still smoked, it would be violently rejected.

Her friend has to develop her OWN plan of action.

Her friend, when she decides to quit, can reference what has worked for other people, but for her to succeed, it has to be done HER way, on HER terms.

The cure for RLS is no different.

“I TRIED EVERYTHING AND IT DIDN’T WORK!!!”e4ffe02a476b07a65d62713b69810dac

The most common excuse is “There is no cure because I tried everything and it didn’t work!”

That’s like saying “I TRIED AA AND IT DOESN’T WORK … SO I HAVE NO CHOICE BUT TO CONTINUE DRINKING!”

I know from several people that I’ve talked to that they have dramatically changed their diet. Yet, they still suffer.

It doesn’t mean that there isn’t a solution for them. All it means is that they haven’t found it yet.

Every “cure” is going to be a bit different for each person. Just like with spontaneous remission and my wife’s smoking.

But, there IS a cure that exists for every one of you reading this.

It all comes down to how much effort are you willing to put into finding it? And are you willing to change your actions, beliefs and attitudes?

SO WHO IS THIS “EXPERT” THAT SAYS THERE IS NO CURE?41i6JstccgL._SY300_

Who is this mystery person that originally informed the world that there is no cure for Restless Legs Syndrome?

Maybe it’s Dr. Mark Buchfuhrer, the legendary RLS specialist “Dr. B” that used to be in a Mirapex commercial?

It can’t be any of the doctors that I’ve quoted from articles and studies. They’re all quacks.

Regardless of who the source is, I’ve never been shown one solid piece of evidence showing that RLS is not curable. In fact it’s quite the opposite.

It’s always just a knee-jerk reaction, with no evidence to support the “incurable” claim.

It’s kind of like atheists continually asking people to prove there is a God. Yet, they’ve never offered one grain of evidence proving there isn’t.

MY SMALL BUT GROWING DATABASE OF SUCCESS STORIESsmall-cap

The truth is more and more people are taking the situation into their own hands and are making the necessary changes to become free of there RLS.

You can read about several of them here: http://www.rlcure.com

tag-SpontaneousRemissionsIN CLOSING

Let’s face it, what people really mean when they say there is no cure for RLS, is that there is no DRUG that will take it away.

All the successes that happen to the flaky people are anecdotal. There’s no substance to any of it.

For those of you suffering from RLS, I wish you the very best.

I sincerely hope that you can draw some inspiration from the Spontaneous Remission Project.

You can read it online here:
http://www.noetic.org/library/publication-books/spontaneous-remission-annotated-bibliography

 

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RESTLESS LEGS SUCCESS STORY: Nadine Ausen, Waukesha, Wisconsin

nadinea“I was diagnosed with RLS about sixteen years ago. My symptoms were primarily showing themselves in the evening, making it difficult to sit and watch TV, go to a concert, etc, let alone go to bed and sleep.

I had tried lots of drugstore sleep remedies with little relief before being diagnosed.

After the diagnosis, I started on Requip, which really gave me a lot of symptom relief. Problem was, I was almost unable to stay awake during the evening, long before wanting to go to bed for the night. Also, while the legs were quieted, I found myself still restless and irritable, so after awhile, I was switched to Mirapex. Things were somewhat better for awhile, until augmentation began.

Symptoms began earlier in the day, and required more drug to suppress them, so that I would zonk out when the symptoms let up. I read enough information to realize that this class of drugs would probably have to be abandoned soon, leaving others that would be very sedating, as well. Kind of a depressing outlook, since I don’t really aspire to die in the next few years.

On day my daughter sent me a website http://www.rlcure.com that talked about natural remedies for RLS (this was after yet another conversation with me about how bummed I was about this miserable ailment and wondering what shape I’d be in in the coming years).

As a very experienced RN, and a natural skeptic besides, my first thought was “Oh, RiGHT!”, and after reading a little on the site, I thought, “How can I do all that?” Yet, as a nurse, it did make some sense to me. I already knew about the evidence showing that inflammation plays a role in a lot of medical conditions, so was it really so far-fetched to see it as a factor in RLS? Then there was the question my husband posed…”Wouldn’t you do almost anything to get rid of that?”

I started with cayenne (which I stopped because of frequent stomach upset) and Curcamin which is a combo drug available at some natural or organic stores as well as via Amazon. I am sorry to say that I don’t know for certain what the third one was that I took, but I can tell you that magnesium, calcium, B-12 sublingual, B complex and Quercitin with Bromelain (also found at natural stores or Amazon) were added soon, and help me a lot.

I also drink carrot juice. Of course, everyone has their own scenario of symptoms. There is also a large list of supplements in which to choose, but I have stuck with these.

I also occasionally use L-theanine to help settle me when I am especially bothered. It’s very mild, just calming.

After only a few weeks, I was able to decrease my Mirapex by half.

The dietary changes are harder, but when I follow them, my evenings are better.
Since they are mostly principles I should follow for glucose and weight control as well, I am working on better compliance, and truly believe I may be able to be prescription – free in time. And even if I don’t get that far, I am in a much better situation and feel much less helpless because of the anti-inflammatory approach.

It is a great feeling to believe you can be proactive in dealing with this illness!! I have passed along some of this to others, and highly recommend trying this method to anyone living with this nasty condition….”Wouldn’t you do almost anything to get rid of that?”

About me: I am 66yrs. old, lived all my life in Wisconsin. Have been married for 44 yrs, and worked for 43 yrs as an RN, most of it in hospital nursing, with many years in cardiology and cardiac surgery. We have an adult son and daughter, a grandson who is 5 yrs, old, and will be excited to welcome a granddaughter in October. We also love our pets, traveling, and music. We enjoy a wonderful Christian church. We are becoming more health-conscious as we get older, and really hope to be active “senior citizens”! having my RLS under control will be important for that.

_______________________________________________

For more RLS success stories visit http://www.rlcure.com
If you have a success story, please e-mail me at dwimble@magma.ca

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SEVEN Common Myths About Restless Legs Syndrome

seven-common-myths-about-restless-legs-syndromeMYTH #1: RLS IS GENETIC

TRUTH: The “tendencies” that cause RLS are passed down from parent to child. These tendencies are VERY changeable. They are not hard-coded.

Epigenetics are the switches that turn these tendencies OFF or ON.

Science now knows with absolute certainty that genetics play a much smaller role than previously thought.

Here’s a quote from Newsweek Magazine about the new exciting world of epigenetics.

“Roll over, Mendel. Watson and Crick. They are so your old man’s version of DNA. And that big multibillion-dollar hullabaloo called the Human Genome Project? To some scientists, it’s beginning to look like an expensive genetic floor pad for a much more intricate – and dynamic – tapestry of life that lies on top of it.” - Newsweek Magazine, June 2009

Genetics determine certain traits that are passed on to children, such as hair color, the shape of the nose etc. (as we all learned in school) but beliefs, tendencies and conditions that are passed on are passed through what is called “epigenetics.” These are the switches that determine how our genes are going to act.

For instance, if a parent was extremely negative, those negative switches would be already turned on in the child’s genetic makeup, even before it was born. The child would have to take an action to change the switches to turn the positive genes on and the negative genes off.

In the case of RLS, the bad switches could be on because of diet, environment, and in a lot of cases, stress. This would create inflammation in the parent, and at some point in the child’s life, sometimes very early. These switches would cause inflammation to build until actions were taken and changes were made.

Here’s a quote from a 2012 study:

“Phenocopies in families with essential tremor and restless legs syndrome challenge Mendelian laws. Epigenetics might provide answers.” Zimprich A. Parkinsonism Relat Disord. 2012 Jul;18(6):711-6.

“There is increasing evidence that epigenetic modifications, which refer to changes in gene expression without changes in DNA sequence, can be transmitted to the next generation. Moreover, epigenetic information can be transferred from one allele of a gene to the other allele of the same gene; if then inherited to the next generation, the offspring consequently presents phenotypic properties related to the untransmitted allele.”

Note that if a parent had inflammatory tendencies in the way they lived their life, the inflammation could eventually manifest in the child in a number of ways. It could become RLS as well as hundreds of other inflammatory conditions including depression, ADHD, Parkinson’s etc.

For an extensive look at epigenetics visit:
http://www.rlcure.com/epigenetics-and-restless-legs-syndrome.html

hypnosis-hypnotherapy-fibromyalgia-ibs-cfs-441x269MYTH #2: THERE ARE “TWO” TYPES OF RLS –  PRIMARY AND SECONDARY  

TRUTH: There is only ONE type of RLS. RLS is ALWAYS caused by inflammation, not by another condition.

Having chronic inflammation in your body is like spilling a coffee on your keyboard. Something unpleasant is going to happen, you’re just not sure what.

In the now famous 2012 study by Dr. Leonard Weinstock titled “Restless Legs Syndrome: Theoretical Roles of Inflammatory and Immune Mechanisms” it was shown that 36 of the 41 RLS-associated conditions (88%) have been associated with inflammatory and/or immune changes.

According to the study “The fact that the majority of highly RLS associated conditions are also associated with inflammatory/immune changes suggests the possibility that RLS may be mediated or affected through these mechanisms.”

Parkinson’s, IBS, SIBO, Cancer or any of the other secondary conditions the study refers to do not cause RLS. Inflammation is causing BOTH of the conditions.

Keep in mind that inflammation can manifest as one condition, two conditions or more if it’s not addressed.

You can read about the study at the website below, which also includes some additional data that shows why the results should have shown that 100% of the conditions are associated with inflammation.

http://www.rlcure.com/scientific-study-suggests-inflammation-is-a-primary-cause-of-RLS.html

iron levelsMYTH #3: IRON DEFICIENCY IS A PRIMARY CAUSE OF RLS  

TRUTH: The inflammation causing the RLS also affects iron levels.

The medical text “Hyperkinetic Movement Disorders: Differential Diagnosis and Treatment” by Alberto Albanese and Joseph Jankovic (John Wiley & Sons, 2012) is a scholarly work written for pediatric and adult endocrinologists, orthopaedic surgeons, roentgenologists, workers in rheumatology clinics, geneticists, nutritionists and very specialized osteologists. The book is a collection of data and observations made through a variety of scientific studies.

Chapter 20 of the book focuses on Restless Legs Syndrome. On page 311, Arthur S. Walters M.D. of the Vanderbilt Department of Neurology is quoted.

“Most recently we have noted that RLS patients have an increased prevalence of Irritable Bowel Syndrome (IBS) and an increased prevalence of Small Intestinal Bacterial Overgrowth (SIBO) compared to controls. This led us to review the 40 or so secondary causes of RLS. Independent of RLS, the vast majority of these secondary causes are associated with either iron deficiency, SIBO or inflammatory/immune abnormalities.

This suggests that inflammation and immune attacks on the peripheral or central nervous system in RLS could be pathogenetic to RLS.

An alternative explanation is that inflammation may lead to iron deficiency which may in turn lead to RLS.”

It is well known in the scientific community that inflammation can affect iron levels. Below are a couple of studies that support this idea:

“Influence of acute inflammation on iron and nutritional status indexes in older inpatients.” MM Chiari et al. J Am Geriatr Soc. 1995 Jul;43(7):767-71.

“Patients with acute inflammation present altered iron status indexes that resemble those observed in the anemia of chronic disease.”

“Interpretation of biochemical tests for iron deficiency: diagnostic difficulties related to limitations of individual tests.” Frank Firkin, Director of Clinical Haematology; and Bryan Rush, Director of Laboratory Haematology, St Vincent’s Hospital, Melbourne.

“Most cases of iron deficiency can be diagnosed with simple tests. The concentration of serum iron does not fall until the body’s iron stores are exhausted. As the stores are depleted, the concentration of transferrin rises while the concentration of ferritin falls.

Caution is required when assessing patients with inflammatory disease as a low serum iron may not represent iron deficiency. These patients often have reduced concentrations of transferrin.”

MYTH #4: RLS IS CAUSED BY AN IMBALANCE OF DOPAMINE LEVELSPost4_1

TRUTH: The dopamine imbalance and the Restless Legs are BOTH caused by INFLAMMATION.

A dopamine imbalance can be caused by low iron levels or directly from inflammation as is stated in the following studies:

“CSF iron, ferritin and transferrin levels in restless legs syndrome.” Soichi Mizuno et al. Department of Psychiatry, Shimane University School of Medicine, Shimane, Japan, February 2004.

“The results of this MRI study suggest that idiopathic RLS patients may have a dysfunction of dopamine production induced by the iron deficiency in a dopamine-related specific area of the brain, and support the iron-dopamine model of this syndrome.

“Iron deficiency alters expression of dopamine-related genes in the ventral midbrain in mice” L.C. Jellena et al. Neuroscience, Volume 252, 12 November 2013, Pages 13–23

“A clear link exists between iron deficiency (ID) and nigrostriatal dopamine malfunction. This link appears to play an important role in at least restless legs syndrome (RLS) if not several other neurological diseases.”  

“Iron deficiency alters dopamine uptake and response to L-DOPA injection in Sprague–Dawley rats.” Laura E. Bianco1 et al. Journal of Neurochemistry, Volume 106, Issue 1, pages 205–215, July 2008.

“Iron deficiency (ID) disrupts brain dopamine (DA) and norepinephrine (NE) metabolism including functioning of monoamine transporters and receptors.”

“Inflammation induces mitochondrial dysfunction and dopaminergic neurodegeneration in the nigrostriatal system.” RL Hunter et al. Journal of Neurochemistry. 2007 Mar;100(5):1375-86.  

“Evidence suggests that chronic inflammation, mitochondrial dysfunction, and oxidative stress play significant and perhaps synergistic roles in Parkinson’s disease (PD), where the primary pathology is significant loss of the dopaminergic neurons in the substantia nigra.”

“Systemic Infusion of Naloxone Reduces Degeneration of Rat Substantia Nigral Dopaminergic Neurons Induced by Intranigral Injection of Lipopolysaccharide.” Bin Liu et al. The Journal of Pharmcology and Experimental Therapeutics Vol. 295, No. 1, JPET 295:125-132, (2000).

“A massive degeneration of dopamine-containing neurons in the substantia nigra (SN) in the midbrain is characteristic of Parkinson’s disease. Inflammation in the brain has long been speculated to play a role in the pathogenesis of this neurological disorder.”

Timeline Cover for RLS Awareness Week 2013 v1MYTH #5: RESTLESS LEGS SYNDROME IS A DISEASE

TRUTH: RLS is a BIOMARKER indicating that your body is dangerously INFLAMED and that ACTIONS must be taken to prevent further damage.

RLS is now officially Willis-Ekbom Disease (WED). The name change occurred a few years ago to give it more credibility, but the truth is it’s an uninspiring name and is rarely used by anyone outside of RLS.org.  

The body is an incredibly complex machine and one of its survival mechanisms is its ability to send our warning signals when something is not right underneath the hood.

For example, frequent headaches indicate that something beneath the surface needs to be attended to, whether it be stress, lifestyle, a tumor, inflammation or something else.

In the case of RLS, your body is telling you that you have too much inflammation and that it must be dealt with. If no changes are made, the inflammation will increase and lead to additional conditions.

A nationally-recognized sleep expert has published an editorial describing Restless Legs Syndrome (RLS) as a possible biomarker for underlying disease. The editorial appears in the March 5, 2014 issue of Neurology the medical journal of the American Academy of Neurology and was authored by Boston Medical Center neurologist Sanford H. Auerbach, MD.

Auerbach suggests that restless leg syndrome is a meaningful biomarker for serious disease, and that RLS screening may become more common as a tool for primary care providers to identify patients at risk.

Find out more here:

http://medicalxpress.com/news/2014-03-restless-legs-syndrome-signify-bigger.html
http://www.rlcure.com/restless-legs-syndrome-willis-ekbom-is-not-a-disease.html

MYTH #6: RLS IS OFTEN CAUSED BY PREGNANCYpregnant-woman-doctor-24049835

TRUTH: The RLS is caused by the HIGHER presence of INFLAMMATION in pregnant women.

As the studies below demonstrate, inflammation levels tend to increase in pregnant women.

“Vaginal cytokines in normal pregnancy.” G. Gilbert et al. American Journal of Obstetrics and Gynecology, vol. 189, no. 5, pp. 1433–1438, 2003.

“A significant increase of proinflammatory cytokines (IL-6 and IL-8) is produced in the third trimester. These cytokines act as chemoattractants of polymorphonuclear leukocytes stimulating the expression of prostaglandins in response to delivery preparation.”

“C Reactive Protein levels are elevated in the Third Trimester in Preeclamptic pregnant Women.” Zaima Ali et al. Dept. of Physiology, Lahore Medical and Dental College, Department of Obstetrics and Gynecology, Jinnah Hospital, Lahore.

“Pregnancy is a complex process which leads to a number of systemic changes. During normal pregnancy all these changes are very well regulated. Preeclampsia is a very common disorder of pregnancy and is characterized by hypertension and proteinuria that begins at more than 20 weeks of gestation. Poor placentation with inadequate cytotrophoblast invasion results in widespread maternal endothelial dysfunction. There is increasing evidence that preeclampsia is accompanied by exaggerated maternal systemic inflammatory response to this poor placentation.”

“Prokineticin-1: A Novel Mediator of the Inflammatory Response in Third-Trimester Human Placenta.“ Fiona C. Denison et al. Endocrinology. 2008 July; 149(7): 3470–3477. doi:  10.1210/en.2007-1695

“Prokineticin-1 (PK1) is a recently described protein with a wide range of functions, including tissue-specific angiogenesis, modulation of inflammatory responses, and regulation of hemopoiesis. The aim of this study was to investigate the localization and expression of PK1 and PK receptor-1 (PKR1), their signaling pathways, and the effect of PK1 on expression of the inflammatory mediators cyclooxygenase (COX)-2 and IL-8 in third-trimester placenta.

Our study demonstrates that PK1 and PKR1 are highly expressed in third-trimester placenta with PK1 up-regulating expression of IL-8 and COX-2 potentially via activation of PKR1 and cross-talk with EGFR. The latter finding is supported by double-immunofluorescent immunohistochemistry studies that show that PKR1 colocalizes with IL-8 and COX-2 in placenta. Together, these data suggest that PK1 may be a novel paracrine mediator of the inflammatory response in third-trimester placenta.”

Senior Hispanic woman rubbing handMYTH #7: AGING TENDS TO CAUSE RLS

TRUTH: The RLS is caused by the HIGHER presence of INFLAMMATION in elderly people.

As the studies below demonstrate, inflammation levels tend to be higher in the elderly population.

“Inflammation in aging: cause, effect, or both?” NS Jenny. Discov Med. 2012 Jun;13(73):451-60.

“Aging is a progressive degenerative process tightly integrated with inflammation.”

“Chronic Low-Grade Inflammation in Elderly Persons Is Associated with Altered Tryptophan and Tyrosine Metabolism: Role in Neuropsychiatric Symptoms.” L. Capuron et al. Biol Psychiatry. 2011 Jan 28.

“Our findings show that chronic low-grade inflammation in aging is associated with alterations in enzymatic pathways involved in monoamine metabolism and suggest that these alterations might participate in the pathophysiology of neuropsychiatric symptoms in elderly persons.”

“Age-related alterations in retinal neurovascular and inflammatory transcripts.” CA Van Kirk et al. Mol Vis. 2011;17:1261-74.

“The commonalities in retinal age-related and diabetes-induced molecular alterations provide support for the hypothesis that diabetes and aging engage some common para-inflammatory processes.”

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RESTLESS LEGS SUCCESS STORY: David Wimble, Ottawa, Ontario

googleplus2“I am all too familiar with that horrible feeling of lying in bed, desperately trying to fall asleep BEFORE your legs start twitching. I know the deep despair of lying there and feeling that FIRST little spark. That tiny rustle that signals the inevitable.

That small rustle is the signal that it’s going to be ANOTHER restless night. The twitching is going to get worse until you finally have to get up and walk around (my wife called it travellin’) or sit at your desk and work, until you’re so exhausted that you feel there’s a SLIGHT chance you may be able to fall asleep before the twitching returns again.

During the evening, I could barely SIT beside my wife Barb, let alone HOLD her hand as we would watch TV. Often, my legs would be buzzing so intensely, I would have NO choice but to watch TV standing up.

I used to FLY to a lot of MUSIC conferences. I remember how I would try to mentally prepare myself DAYS before the trip. There’s nothing more intimidating to a RLS sufferer than knowing you’ll have to sit STILL in a plane seat for FIVE HOURS. Sure enough, after a SHORT grace period, the twitching would begin. I can’t tell you how many times I WALKED up and down the airplane aisle pretending that I had to go to the bathroom, just to walk off my wonky legs.

And sadly, many times, during the early hours of the morning, in the exhausting depths of ANOTHER sleepless night, I harbored the extreme fantasies of how peaceful life would be if I had no legs.

I would by lying if I said that thoughts of suicide also didn’t enter into my consciousness.

I can’t remember exactly when it all started? I didn’t even know it had a name until a few years ago. Barb told me one morning that she had run across an article about Restless Legs Syndrome. Up until that time, it was just my “wonky legs” acting up again.

I started researching and found that the only remedies that were being used were horrific drugs created initially for Parkinson’s patients and for those suffering from seizures & epilepsy. I thought about it, but decided that they were not for me.

Through the years I tried all sorts of teas, diets, oils, vitamins and massage. I tried workouts, bicycling and jogging. Nothing helped, or at least NOT for very long.

Several years ago, Barb suggested that I go see a Chiropractor … so I gave it a shot. I was pleasantly surprised that it seattle-chiropractoractually helped a bit. However, after the INITIAL relief, the treatments started LOSING their effectiveness. After about a year, I gave up and stopped going.

A few years later a local Acupuncturist was recommended to me. I went and saw him for a treatment. I was amazed at the relief I gained through his combination of electro-acupuncture followed by a DEEP tissue massage. The massage was excruciating, but I stuck it out because I was DESPERATE to get rid of my twitchy legs. He had hands like a mechanic, and TEARS would shoot out of my eyes as he massaged my legs, but I kept going to see him. It was the MOST relief I’d ever had from my restless legs.

I saw him periodically for a couple of years, and eventually, as was the case with the Chiropractor, the treatments became non effective. I was DEVASTATED. I felt like I was COMPLETELY out of options.

The acupuncturist had told me that my issue was inflammation in the legs. I thought, if this is the cause, maybe there is some sort of herb or supplement that could lessen my inflammation, and therefore lessen my symptoms?

I went to my local health food store and the clerk told me that curcumin was a good natural anti-inflammatory.

I took the curcumin with each meal and within days was feeling better.

Over the next few years I continued researching and trying out different natural anti-inflammatories including Omega 3, Ginger Root, Cayenne, St. John’s Wort, Licorice Root and Skullcap, along with Carrot Juice, Vitamins and Minerals. Slowly but surely the RLS went away.

As I continued educating myself, it became apparent that a healthy diet was crucial. I could take all the anti-inflammatories in the world, but if I was still eating inflammatory foods, then there wouldn’t be a lot of healing going on.

brain-foodSo, I radically changed my diet and continued to take supplements. I rarely eat meat now and my sugar and fat intake is way down. I slso keep away from starches as much as I can including rice, potatoes and pasta. I switched from regular milk to almond milk to pour on my ceral and make my smoothies (I found that I had an intolerance to soy and soy milk).

I recently learned about the importance of probiotics and are now taking them to help my digestive system to function correctly.

I also learned that stress is another big trigger of inflammation. I meditate every day, which helps to lessen the stress.

I have never even remotely felt this good in my entire life. Even pre-RLS.

My advice to those of you still suffering is to ignore those that say there is no cure. Even the doctors. Actually, especially the doctors. They really have no clue about the cause. They may have read an article or pamphlet. or glanced at a study, and that’s truthfully all they know about it.

It really bothers me when someone says I couldn’t have really had RLS because there is no cure. Since I got better, it must have been something else.

My RLS was as bad as anyone that I’ve ever talked to, and today, I feel like a million dollars – like I’ve been freed from a hellish prison. “

If you have a success story, please e-mail me at dwimble@magma.ca

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RESTLESS LEGS SUCCESS STORY: Jonathan Nielsen, California

JonathanNielsen1“I’ve had RLS for many years, although ordinarily it was a minor annoyance. Although, during the past couple of years it got considerably worse, to the point that something had to change. It took a lot of searching to discover the real causes.

In the meantime (while I made the changes, like learning to drink enough pure, clean water and avoiding bad food ingredients), I needed something to help me sleep, while still in process of addressing the root causes of problems the drug companies want to treat with drugs (trust me, you don’t have a deficiency of whatever drug they want to prescribe).

I have found that the following supplements greatly help many people to sleep and to have significant reduction in RLS symptoms. I take the third one listed every night, although I’ve tried the others. They are the only things I’ve taken that were effective for my RLS symptoms besides drinking more water, exercising more, and improving my diet.

Now that I’ve increased my water intake (I don’t drink anything else now), my RLS symptoms are very mild, more like 5% of what they were.

Here are the herbs that help with RLS, stress, anxiety, and insomnia:

(1) Kava kava root extract (often just called “kava”), from a plant that grows on islands in the South Pacific, has been used by Polynesians for thousands of years. It is ignored by mainstream medicine because it’s not nearly as expensive as the prescription drugs, plus it’s not addictive and has no side effects, and they can’t patent it. Instead they try to make kava kava sound unsafe with warnings about liver damage. However, liver damage can only occur if other parts of the plant besides the root are used. Find a trustworthy manufacturer that uses only the root, and there’s no need to worry.

(2) Passion flower extract, from a plant native to North America, was used for centuries by Native Americans, is like kava in that mainstream medicine prefers you use their prescription drugs instead. Passion flower cannot safely be taken at the same time as kava, because both thin the blood some. This also makes both incompatible with some over-the-counter medications like aspirin, ibuprofen, and acetaminophen.

9828010_m1(3) Valerian, from Europe and Asia, was used as long ago as ancient Greece and the Roman Empire. Side effects are almost never seen, and the herb is found by many to work much like benzodiazepines but without the addictive qualities and other problems. Once again, mainstream medicine prefers you not know about it. Valerian also cannot be taken at the same time as kava, due to the fact that both are processed by the liver and overtaxation of the liver could result.

Valerian needs to be taken every day and becomes very effective after two to three weeks. The others can be taken at moments when anxiety, RLS, or whatever needs something. Of the three, I find valerian to be the best.

Note that valerian and passion flower can be taken together.

Since natural supplements are not supported by the government or the medical industry (who are really on the same side), it can be difficult to find information about them. Online research should tell you what the supplements are and aren’t compatible with, what dosages are safe, whether the supplement loses its effectiveness over time, and other needed information. All this is readily available with prescription drugs, but information on supplements including clinical trial information is almost nonexistent or may actually be misleading if the drug companies had a hand in it.

Information can be difficult to find, but it’s very important. The medical industry may actually be harming people by refusing to provide information (or accurate information) about natural supplements, and sticking to their position that everyone just needs the expensive patented prescription drugs (while minimizing, hiding, and denying the drugs’ harmfulness).

For the best website I’ve found that assists with determining interactions of drugs, also including information about many supplements, see LetsDrug.com.

FOCUSING ON YOUR OVERALL HEALTH AND LIFESTYLE WILL MAKE THE BIGGEST DIFFERENCE

Exercising. I must re-emphasize the importance of overall health, which is adversely affected by insufficient physical activity, use of harmful substances like tobacco and alcohol and many drugs (prescription and illegal), consuming problematic food ingredients, and inadequate intake of pure, clean water (the last of which, as stated, causes dehydration and many “diseases” that result from dehydration).

relax-blocksOther factors critical to health include getting some sun, getting adequate sleep, and overcoming psychological stress.

To learn about food ingredients which are major culprits in causing major health problems, Learning about these is important because they are very common in foods in nearly every aisle of the grocery store, and they can very much worsen inflammation and many health problems, such as RLS.

Most major food companies generally aim to make you addicted to their products, and to maximize profits at the expense of providing healthy products. The FDA allows nearly every deceptive thing the food companies do, which shows why you need to take personal responsibility and educate yourself, rather than rely on the government to protect you and keep you safe.”

If you have a success story, please e-mail me at dwimble@magma.ca

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