The Truth About Restless Legs Syndrome (RLS)

This RLS Blog contains a LOT of information about Restless Legs Syndrome, covering a wide spectrum of different areas and aspects.

Because of that, a casual passerby at 4am that’s just trying to find a solution for their wonky legs may be overwhelmed or frustrated as they have to dig through information on epigenetics, glutamate, histamine etc. in order to find out what this “CURE” is all about.

For that reason I have created this post which I will LOCK into the first position on the blog so that this overview of “An Absolute Cure for RLS” will always be visible to newcomers.


Throughout our early history the majority of the world’s population considered the earth to be flat. That was a normal way to think.

If you were to shout out that the world was ROUND back then, you would have probably been pelted with rotten vegetables.

You would have been called a NUT … a person DESPERATE for attention.

And then things changed.

In the early 16th century, Ferdinand Magellan proved to the Western World, that without a doubt, the world was in fact ROUND.

A new awareness was created.

But there were MANY before him that had the same knowledge. Ferdinand Magellan was simply part of a lineage of belief.

Despite the fact that most of the 300 million inhabitants of the planet in the early 1600’s believed the world to be flat, and but a small handful of astronomer-types believed it to be round, the truth was never altered. Not for a second. It was ALWAYS waiting there to be discovered.

A belief never has nor ever will alter the truth. The number of people supporting the belief does not matter.

ImageSo, What’s My Point?

Please understand, I’m not saying that I’m ANYTHING like Ferdinand Magellan. He had more courage in his baby toe than I have in my entire body.

But, despite my foibles, I have also stumbled upon a truth. And despite what anyone says, regardless of their intelligence, their degrees, their stature or whatever opinion they may have, there is NOTHING on earth that is going to change this simple truth that I have stumbled upon.

The simple truth is this basic formula.


Regardless of what your reaction may be to me, my views, or natural remedies in general … this truth that I am presenting to you is NEVER going to change.



There is NO case of RLS that is beyond repair.

But please note … it is a PROCESS of RECOVERY. There is no magic pill.

You are exchanging your inflammatory diet and lifestyle (removing whatever it is in your life that is causing the inflammation in your body) for an anti-inflammatory diet and lifestyle.

As you can imagine, many sacrifices will need to be made. Some will be drastic. For starters you need to cut down on inflammatory items such as sugar, alcohol, refined flours, caffeine and dairy.

It may seem impossible, but if you move in this healthy direction, I can assure you that the sacrifices you make will pay off.

ImageI had horrible RLS for 23 years. I am now living a life I could have only dreamed of a few years ago. Words cannot express how grateful and relieved I am to have normal healthy legs and regular sleeping habits.

Something I learned from my own experience is that the MORE effort you put into your recovery, the FASTER you will heal.

If the only change you’re willing to make is to buy some magnesium or cut down on your sugar intake, then your recovery will be SLOW.

If you follow the advice given on this website, and go at your recovery with EVERYTHING you have … you will be rewarded for your efforts!


If a fire breaks out in your kitchen, the first thing you need to do in order to save your house is to put out the fire!

It’s pretty basic logic. You can worry about the smoke damage, your melted toaster, the ruined curtains and whether or not your insurance covers the damage … after the fact.

But until you put that fire out, nothing else matters.

You must take the same approach when taking on your RLS. You must first PUT OUT the fire that is causing your restless legs.

Nothing else matters. You can switch medications all you want … but until you shift your WILL, and make a CONSCIOUS decision to stop eating and drinking the inflamatory substances that are ADDING TO YOUR INFLAMMATION … NOTHING is going to change!


Look at each supplement below as a different firefighter with a firehose. The best way you can attack the inflammation is from ALL angles with as many firefighters as you can round up. This will speed up the healing process immeasurably.

Again, it’s crucial … absolutely essential that you begin to watch your diet. You need to at least pull back a bit from your regular intake of the most common RLS triggers (caffeine, gluten, aspartame, sugar, dairy, salt, MSG, red meat and alcohol).

Taking the supplements while you continue to consume a diet FULL of RLS triggers, is like spraying TWO hoses on the fire – one hose pouring WATER on the fire and the other hose pouring GASOLINE on the fire.

Little progress will be made, if any.


Supplements are often expensive. With that in mind I have created a “BASIC GROUP” of supplements that should be affordable for most people.

For those with a wider budget, I have a list of additional supplements that you can pick and choose from.

Keep in mind that the supplements listed below are addressing THREE main areas.

1. It is certain that you have chronic inflammation. This will be lessened.

2. It is very likely that you have higher than normal histamine levels, which contributes to a racing mind and sleepless nights. This will be lowered.

3. It is very likely that you have higher than normal glutamate levels, which also contributes to a racing mind and sleepless nights. This will be lowered.

Calcium + Magnesium “CalMag” (anti-inflammatory, natural antihistamine, lowers glutamate level)

Magnesium (Mg) is a co-factor in several hundred enzymatic reactions in the human body. Magnesium reduces histamine release. Magnesium plays a direct role in lowering common inflammatory markers.  

Carrot Juice (anti-inflammatory)

Carrots are perhaps best known for their rich supply of the antioxidant nutrient that was actually named for them: beta-carotene. However, these delicious root vegetables are the source not only of beta-carotene, but also of a wide variety of antioxidants and other health-supporting nutrients.

ImageCurcumin (anti-inflammatory, natural antihistamine)

A component of the popular Indian curry spice turmeric, Curcumin is considered a potent non-steroidal, anti-inflammatory. Curcumin has been shown to be as effective as cortisone and phenylbutazone in decreasing inflammation. It also works in several ways to decrease inflammation by reducing prostaglandin activity.

Grape Seed Extract (anti-inflammatory, natural antihistamine, lowers glutamate level)

Grape Seed Extract is one of the most potent antioxidants known; over 50 times more potent than Vitamin E or C. It acts as a natural antihistamine and anti-inflammatory. The main active component is its high content of proanthocyanidin (OPC or PCO). Proanthocyanidin is found in red, white, and purple grapes, blueberries, cherries and plums.

Iron (anti-inflammatory)

Iron is an essential mineral whose main function is to help carry oxygen from the lungs to the muscles and other organs. Iron deficiency is more common than many think. It is estimated that only 65-70% of all Americans meet their daily recommended intake.

ImageL-Theanine (lowers glutamate level)

L-Theanine is thought to be the key to tea’s subtle but calming effects despite the caffeine content in tea. L-Theanine is thought to counter the stimulating effects of caffeine by increasing the production of alpha brain waves. Alpha waves are associated with a state of deep relaxation while being mentally alert.

Omega 3 (anti-inflammatory, natural antihistamine)

Extensive research indicates that omega-3 fats reduce inflammation, helping to prevent inflammatory diseases like heart disease and arthritis. The omega-3 fatty acids can also be natural antihistamines that are useful to combat allergies as they reduce the inflammatory reaction associated with allergies.

Valerian Tea (anti-inflammatory, natural antihistamine, lowers glutamate level)

Valerian works exceedingly well for anxiety, insomnia and stress. Many people don’t know about one of the oldest herbs in existence valerian. Valerian has many healing qualities … in fact the latin root word valere means to be healthy. Valerian is one of the best herbs for stress … helping with insomnia, restlessness, nervousness, and inducing relaxation. Valerian is a good anti-inflammatory agent helping with swelling, pain, and redness… plus it also calms nerves … and promotes peace of mind.

Vitamin C(anti-inflammatory, natural antihistamine)vitamincinskincare

In addition to being a powerful anti-oxidant and immune booster, some studies have shown that high doses of vitamin c can help reduce sensitivity to allergens and reduce inflammation, mucus production and wheezing.

Water (anti-inflammatory, natural antihistamine)

Drinking plenty of water is one of the most effective natural remedies for inflammation. Water reduces inflammation and promotes cartilage health. To reduce internal inflammation, drink water to carry away waste products. Your body releases histamine in order to stop water loss. If you give your body adequate amounts of water, less histamine will be released.

For a list of references and citations please visit:


I urge you to read through the information on my main website

It’s all free information. Nothing is hidden from you.

This method has worked for me and many others. And it will work for ANYONE that is willing to change their lifestyle – to allow the inflammation in their body to cool down.

How you find the source of your inflammation, that’s your own personal journey. The RLcure website will guide you along, and show you where to look.

When you find out what is causing the inflammation in your body, that is the day you can start waving good-bye to your RLS forever!

I highly recommend that you take a moment to view the TESTIMONIALS from people that this “Absolute Cure” has helped.

These testimonials will hopefully help you to understand that recovery is possible, EVEN FOR YOU … no matter how HORRIBLE your RLS has become!

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Dr. Della Parker3Systemic Inflammation and Immune Dysregulation
Restless legs syndrome has been associated with numerous conditions involving systemic inflammation and immune dysregulation. One review paper published in 2012 investigated health conditions that were reported to cause or exacerbate RLS symptoms, and found that 95% of the 38 different health conditions that were strongly associated with RLS have an inflammation or immune component. These conditions include Parkinson’s disease, multiple sclerosis, ADHD, Alzheimer’s disease, Celiac disease, Crohn’s disease, rheumatoid arthritis, sleep apnea, diabetes, and depression.
As further evidence, an elevated blood level of C-reactive protein (a marker of systemic inflammation) has been associated with increased RLS severity. (5) A small crossover trial found that a hydrocortisone infusion, which reduces systemic inflammation, reduced RLS symptoms.
Researchers have proposed three potential mechanisms to explain the association between RLS and inflammatory or autoimmune states: direct autoimmune attack on the nervous system; genetic factors that could predispose an individual to RLS and be triggered by inflammation or autoimmunity; and iron deficiency caused by inflammation, which I’ll talk more about below.
What to do: If your RLS is a symptom of underlying systemic inflammation or immune dysregulation, the goal should be to find and treat the root cause. As I’ve mentioned many times in the past, gut infections are often the culprit—even if you don’t have noticeable digestive symptoms—so get your gut tested.
If you already have a diagnosed inflammatory or immune condition such as those I mentioned above, the best first step you can take is to adopt a “low-inflammatory” diet and lifestyle. This means eating a nutrient-rich, low-toxin diet based on whole foods; getting enough sleep every night; prioritizing stress management; and incorporating regular movement into your day.
You can also check out the bonus chapter about autoimmune disease from my book, as well as explore other information on my site about reversing autoimmune disease, the autoimmune protocol, the role of the microbiome, and alternative therapies such as LDN.
You can read the entire article here:
Dr. Della Parker, a naturopathic doctor, was born and raised in Portland, Oregon. She graduated from Portland State University with a Bachelor of Science. She then went on to graduate from the National College of Naturopathic Medicine, also in Portland, Oregon. Dr. Della has struggled with health problems throughout her life. Severe asthma and eczema as a child led her down a path of chronic steroid use, which led to many other health problems. It wasn’t until she took a job as a receptionist at a holistic health clinic that she realized how health care could be different. Making basic changes to diet and lifestyle as well as being treated with the holistic model of health, she was able to regain and take control of her health. This experience put her on the path of becoming a Naturopathic Physician. Most conventional doctors use a “cookbook” approach to treating patients. They use protocols to treat diseases while disregarding the host. This takes the functioning of the individual’s body out of the equation. Dr. Della rejects this idea and instead uses a holistic approach to treatments. Using the holistic model means that the whole person is addressed. For example, ten different patients could present with high cholesterol. They each may receive a different treatment recommendation based on the functioning of their whole body.

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A Japanese Study Has Found an Association Between RESTLESS LEGS SYNDROME and INFLAMMATION

sleepcoverDr. Terumi Higuchi of the Department of Nephrology, Keiai Hospital, Tokyo Japan, headed a recent study to determine if there was an association between RLS, oxidative stress and inflammation in patients undergoing hemodialysis.

The results of the study were published in the August 2015 edition of the “Sleep Medicine Journal” (Volume 16, Issue 8, Pages 941–948).

The study was called “Association of restless legs syndrome with oxidative stress and inflammation in patients undergoing hemodialysis”

In the HIGHLIGHT section of the study, Dr. Higuchi states that “Restless legs syndrome was associated with oxidative stress and inflammation.”

You can read more details about the study here:

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Tezcan KayaDr. Tezcan Kaya works in the Department of Internal Medicine at Sakarya University in Adapazar, Turkey. He headed a study that was recently published in the May 29, 2015 edition of the Japanese journal “Therapeutic Apheresis and Dialysis”

The article was called “Relationships Between Malnutrition, Inflammation, Sleep Quality, and Restless Legs Syndrome in Hemodialysis Patients.”

Unfortunately for him, the study didn’t turn up the link he was hoping to find between malnutrition and RLS in Hemodialyis patients.

However he did state in the article that “RLS severity is correlated with inflammatory parameters.”

In non-medical terms, what he’s saying is that “when there is a higher degree of inflammation, there tends to be a higher degree of RLS.”

This completely falls in line with the formula I’ve been hitting people over the head with for the last several years:


Hopefully someone will pick up on Dr. Tezcan’s findings and do some further testing.

You can read the abstract from the study here:

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A Wayne State Study is Testing the Effects of Tocotrienols (from Palm Oil) on Restless Legs Syndrome


For many years I’ve waited with great hope that some day there would be a study to test the effectiveness of a natural anti-inflammatory on patients with RLS. Today, I’m extremely excited to announce that dream is coming true!

The article below gives details on a study that is underway that is going to test the effect of powerful anti-inflammatories called “Tocotrienols” on End-Stage Renal Disease (Kidney Disease) and at the same time they are going to measure its effect on Restless Legs Syndrome.

After the article I have posted some details on what Tocotrienols are, and how their anti-inflammatory benefits have tested in regard to other medical conditions.


“A team of researchers led by Pramod Khosla, Ph.D., associate professor of nutrition and food science in the College of Liberal Arts and Sciences at Wayne State University, will study the effects of a daily supplement of a Tocotrienol-rich fraction from palm oil to see if it improves dyslipidemia, a disorder of lipoprotein metabolism that may be manifested by a decrease in the “good” high-density lipoprotein (HDL) cholesterol in patients with ESRD who are on hemodialysis. Tocotrienols are a form of Vitamin E and have been shown in recent years to have diverse health effects. In addition, Khosla’s team will explore the impact on symptoms such as inflammation and symptoms related to Restless Leg Syndrome in the same cohort of patients.

Khosla believes that the supplement will also act as an anti-inflammatory and antioxidant nutrient, leading to improved nutritional status, lipid profiles, and inflammatory and oxidative stress markers in the ESRD patients.

The three-year study, funded by a $2.4 million grant from the Malaysian Palm Oil Board, a premier government agency of Malaysia, will take place in multiple dialysis centers in the United States and Malaysia. The cross-collaboration will allow the investigators to evaluate differences in dietary patterns of 800 dialysis patients in the two countries. With the patient pool in Michigan of predominantly African Americans and Caucasians and the Malaysian cohort comprised of three distinct ethnicities – Malays, Chinese and Indians – the investigators hope to shed light on possible genetic and metabolic differences in the dialysis populations. Additionally, as a significant proportion of dialysis patients suffer from Restless Legs Syndrome — an unpleasant tingling or cramping sensation that impacts the quality of life — the investigators hope to shed some light on the underlying causes for the condition.redpalmoil

“End-stage renal disease patients undergoing chronic hemodialysis experience a higher risk of complications such as cardiovascular disease, dyslipidemia, Restless Leg Syndrome, insomnia and other health issues,” said Khosla. “In this study, we hope to see significant improvements in various biomarkers that should help decrease some of these complications.”

Dr. James Sondheimer, associate professor of medicine and chief of the Division of Nephrology and Hypertension at WSU stated “We hope to gain a better understanding of how tocotrienols, as substances with antioxidant and anti-inflammatory effects, affect clinical outcomes as well as metabolic parameters.”–wss071315.php


Tocotrienols are members of the vitamin E family. An essential nutrient for the body, vitamin E is made up of four tocopherols (alpha, beta, gamma and delta). Tocotrienols are potent gene regulators and modulators of many enzymes involved in human health, helping to quash the inflammation, glycation, and other processes that contribute to age-related diseases. Tocotrienols are increasingly being recognized for their potential roles in protecting against cancer, heart disease, stroke, diabetes, liver disease, neurodegenerative diseases, and even osteoporosis.

Tocotrienols are natural compounds found in select vegetable oils, including rice bran oil and palm oil, wheat germ, barley, saw palmetto, anatto, and certain other types of seeds, nuts, grains, and the oils derived from them. This variant of vitamin E typically only occurs at very low levels in nature.

In studies, Tocotrienols reduced plasma levels of C-reactive protein (CRP), which is both a marker of and a cause in the inflammatory response that damages heart and blood vessels. They reduce other inflammatory mediators such as cytokines.

Tocotrienols are potent antioxidants, which appear to reduce the oxidant-induced inflammation that contributes to bone loss.

553f63ad3015dedf22d0017954155678Tocotrienols given to mice with pancreatic cancer significantly improved their survival. Only 10% of animals in the control group survived for the study period while 70% of those taking tocotrienols survived!1 Pancreatic cancer is a particularly fast-moving and lethal form of cancer, and this study presents a promising new treatment option. Beyond cancer, research is showing that tocotrienols have a place in reducing important risk factors for some of the most lethal chronic diseases. For example, tocotrienols have been found to promote new artery formation after a stroke, lower homocysteine levels, improve insulin sensitivity, protect vital brain circuitry, and even prevent bone loss.

In a study using rabbits, tocotrienol supplementation, after a high-fat diet, significantly lowered a host of markers of both inflammation and heart muscle damage.

Through studies, tocotrienols have been closely linked to neuroprotection through their potent antioxidant properties, as well as their ability to redirect the production of inflammatory molecules to non- or even anti-inflammatory actions.


“Tocotrienol” Wikipedia
“The Little-Known Benefits Of Tocotrienols” by Thomas Rosenthal
Prasad K. Tocotrienols and cardiovascular health. Curr Pharm Des. 2011;17(21):2147-54.
Das S, Mukherjee S, Lekli I, et al. Tocotrienols confer resistance to ischemia in hypercholesterolemic hearts: insight with genomics. Mol Cell Biochem. 2012 Jan;360(1-2):35-45. Nazrun AS, Norazlina M, Norliza M, Nirwana SI. The anti-inflammatory role of vitamin e in prevention of osteoporosis. Adv Pharmacol Sci. 2012;2012:142702.
Nizar AM, Nazrun AS, Norazlina M, Norliza M, Ima Nirwana S. Low dose of tocotrienols protects osteoblasts against oxidative stress. Clin Ter. 2011;162(6):533-8.
Muhammad N, Luke DA, Shuid AN, Mohamed N, Soelaiman IN. Two different isomers of vitamin e prevent bone loss in postmenopausal osteoporosis rat model. Evid Based Complement Alternat Med. 2012;2012:161527.
Tiwari V, Kuhad A, Bishnoi M, Chopra K. Chronic treatment with tocotrienol, an isoform of vitamin E, prevents intracerebroventricular streptozotocin-induced cognitive impairment and oxidative-nitrosative stress in rats. Pharmacol Biochem Behav. 2009 Aug;93(2):183-9.
Kaileh M , Sen R. Role of NF-kappaB in the anti-inflammatory effects of tocotrienols. J Am Coll Nutr. 2010 Jun;29(3 Suppl):334S-339S.

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The Link Between Stroke, Restless Legs Syndrome and Inflammation

11111ast-stroke-posterYou may have read about a new study that’s getting a lot of press. The study shows that severe Restless Legs Syndrome is linked to increased stroke.

Here is an excerpt about the study from an article written by Megan Brooks of MedScape.

“More severe restless legs syndrome (RLS) is associated with an increased risk for stroke, particularly ischemic stroke, a new analysis of data from the Nurses’ Health Study II suggests.

“We were surprised at the importance of taking into account RLS severity — it was only severe RLS, not milder RLS, that was associated with increased risk of stroke,” principal investigator Xiang Gao, MD, PhD, director, Nutritional Epidemiology Lab, Department of Nutritional Sciences, Pennsylvania State University in University Park, said in a statement.”

You can read the full article here:

This is not actually news. There was a study published in 2008 that demonstrated a powerful link between Stroke and Restless Legs Syndrome.

“A new US study has found that people with restless legs syndrome (RLS) have double the risk of stroke and heart disease compared to people without RLS. The study is the work of Dr John W Winkelman, of Harvard Medical School in Boston, Massachusetts, and colleagues, and is published in the Janaury 1st 2008 issue of the journal Neurology.” from “Restless Legs Linked To Increased Stroke And Heart Disease Risk” by Catharine Paddock, Medical News Today

As is the case with many other diseases and conditions, logic dictates that inflammation is the common link and points to the fact that RLS is an inflammatory condition and can therefore be treated if an anti-inflammatory protocol is set into motion.

In other words, stop eating crap that messes up your body.strokex216

Here are some quotes about the link between inflammation and stroke (for more information about the link between RLS and inflammation visit

“Inflammation is an all encompassing term for a complex process that entails multiple cellular, hormonal and biochemical alterations that are both systemic and organ-specific. A panalopy of acute and chronic infections as well as many exogenous and intrinsic sources of inflammation is associated with an increased risk for ischemic stroke.”  from “Inflammation and Stroke” by Bruce M. Coull, Arizona Health Science Center, University of Arizona, Department of Neurology

“Evidence continues to accumulate to suggest important roles for inflammation and genetic factors in the process of atherosclerosis and specifically in stroke. According to the current paradigm, atherosclerosis is not a bland cholesterol storage disease, as previously thought, but a dynamic, chronic, inflammatory condition due to a response to endothelial injury.”  from “Genetic and Inflammatory Mechanisms in Stroke” by Sally Sultan, MD, Columbia University Medical Center

“Recent work in the area of stroke and brain ischemia has demonstrated the significance of the inflammatory response accompanying necrotic brain injury. Acutely, this response appears to contribute to ischemic pathology, and anti-inflammatory strategies have become popular.”  from the study: “The Inflammatory Response in Stroke” by Qing Wang, MD et al. J Neuroimmunol. 2007 May 14.

“Exactly how inflammation plays a role in heart attack and stroke remains a topic of ongoing research. It appears that the inciting event in many heart attacks and some forms of stroke is buildup of fatty, cholesterol-rich plaque in blood vessels.”
Deepak Bhatt, M.D, Chief of Cardiology for the VA Boston Healthcare System (from “Inflammation and Heart Disease” The American Heart Association)

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BikramQuote1(Editor’s Note: While researching online I found this article plugging my website and I’d like to share it with you).

As a contributor to this blog I’ve spoken before about my own health, nutrition and fitness thoughts and issues.

One issue I’ve had, and which I might be able to help others with is Restless Legs Syndrome. If you’ve never had it, you won’t understand it, but if you have you’ll know exactly what I mean when I say it’s a scourge. It’s not debilitating, it’s not exactly painful, it doesn’t stop you doing things, but it does/can have a big impact on quality of life.

So, what is it?

Essentially it’s a restless creeping feeling in one’s legs, particularly in the quads/thighs, and particularly at night and particularly (for me anyway) when sitting down. It’s extremely uncomfortable and I find it at it’s worst during flights or long films, or even just sitting down in my living room watching tv.

I’ve done quite a bit of research in to it, including what people usually say are the biggest triggers (caffeine, stress, poor diet, high blood pressure) and what are the solutions (medication, quinine, stretching etc.).

However, I recently came across a website with some excellent suggestions in it about RLS, and I’m happy to give it a plug here. The chap who runs the website isn’t even selling anything, he just wants to pass on his findings. Here’s the link;

Basically, he says that RLS is completely caused by Inflammation. Now, inflammation is a whole other subject, with a whole other list of causes and symptoms.

However, his cure, which simply involves a combination of herbs which can be purchased at any health store, DOES seem to helping me a lot, so I suggest you have a think about if, if you suffer from RLS.

Two other things that have also helped are;

Bikram Yoga, and again, that’s a whole other subject, which I’ll come back to some day.
ProArgi9 from Synergy Worldwide. The reason I think Pro Argi helps with RLS is that it creates Nitric Oxide in the body and therefore has a big impact on circulation, blood flow (and possibly inflammation) thereby helping the legs to relax, including when seated or lying down at night time.

So, that’s my tuppence worth on Restless Legs Syndrome, a nasty little affliction, and I hope the above may be of some help to fellow sufferers!

Ken Cowley has a background in the leisure industry and sales, and wants to further explore all aspects of health, fitness and wellness and share this with friends and colleagues along the way.

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Debunking the Myth That There is a PRIMARY and SECONDARY type of Restless Legs Syndrome


Since you’re reading this article, it’s safe to assume that you or a loved one suffer from Restless Legs syndrome. You’ve probably read dozens of articles on this mysterious condition. You have come to learn that there is a PRIMARY type of RLS (where the condition develops naturally, without an obvious cause) and a SECONDARY type of RLS (RLS caused by another underlying health condition).

The truth is that there is only ONE kind of RLS, the kind that is caused by chronic inflammation. There is no other type of RLS.


Ankylosing Spondylitis (a chronic inflammatory disease of the axial skeleton) is another condition that you can add to the large number of inflammation-based conditions that show a higher prevalence of RLS. A recent study (Tekatas and Pamuk, 2015) found that RLS was significantly more common in patients with Ankylosing Spondylitis compared with healthy controls (30.8 versus 13.2 percent).

The latin suffix “itis” denotes diseases characterized by inflammation. For example, Arthritis (inflammation of one or more joints), Colitis (inflammation of the colon) etc.

You can be certain that any disease or condition that ends with “itis” is going to demonstrate a higher prevalence of Restless Legs Syndrome within its community. The “itis” disease and RLS are both a result of an underlying chronic inflammation.

Many studies have been performed in recent years that show the undeniable relationship between RLS and inflammatory conditions. To date, there are more than 50 inflammatory conditions that show a higher prevalence of RLS. Many of these studies are cited in the paper “Restless Legs Syndrome: Theoretical Roles of Inflammatory and Immune Mechanisms.” (Weinstock et al, 2012).


Many doctors and scientists believe that the primary cause of most diseases is an underlying inflammation. And that belief is growing in leaps and bounds within the medical community. How it eventually manifests or “shows up on the surface” is based on the lifestyle and genetics of each individual.

In some cases it may manifest as cancer, in others as ALS, and in many it manifests several ways. Depression, IBS, Crohn’s disease … the combinations are endless.

Almost any ailment you can think of has the same issue at its core … inflammation.

If you don’t believe me, do a web search “Depression and inflammation”, “ADHD and inflammation”, “Parkinson’s and inflammation” etc. You’ll find a wealth of information on how they are intimately and undeniably linked.

The fact is, most of the people that contact me with questions or comments have other medical conditions that they are dealing with in addition to their RLS. These conditions are ALWAYS inflammation-based.


As stated, the reason that RLS has a higher prevalence in relationship to so many medical conditions is because the RLS and the medical condition result from the same core issue – chronic inflammation. They’re like different fingers on the same hand.

We’re focused heavily on RLS, because that’s what we’re dealing with in life. That’s how the chronic inflammation has manifested in our lives.

However, you can take ANY inflammatory condition and find that there is a higher prevalence of any other inflammatory condition (provided there has been a study done at some point). RLS is not unique in this mysteriously connected world.

To illustrate this fact, I’ve taken RANDOM pairs of conditions from the list of inflammatory diseases linked to RLS and did some research to see if there is any known link between these random pairs.

health_20090219_depression_bannerHere are the results …

from “Anemia” by MediResource Inc.
“Anemia is very common in people with cancer. In fact, about half of people with cancer develop anemia.”  

from “Depression is more common in people with diabetes compared with the general population” by the Canadian Diabetes Assc.
“Symptoms of depression affect 30% of people with diabetes, while 10% of them experience major depression.”

from “Is there an association between inflammatory bowel disease and Parkinson’s disease?” by European Crohn’s and Colitis Organisation – ECCO
“The proportion of PD having concomitant IBD is considerably higher than one would expect.”

from “Fibromyalgia linked to heart disease in new study” by EmaxHealth
“A new study has found a link between fibromyalgia and coronary heart disease after comparing patients with the condition to control groups. Researchers discovered that there was an association between the two disorders, and fibromyalgia patients were more likely to have heart disease.”

from “Migraine and Obesity: What You Should Know!” by B. Lee Peterlin, DO
“Those with general obesity have a greater prevalence of high frequency migraine (migraines occurring 10-14 days per month) than those without.”

from “Association between ulcerative colitis and multiple sclerosis.” (Pokorny et al. 2007).
“The association between ulcerative colitis and MS appears to be real and may help identify common factors involved in the cause of these two diseases.”

You could spend weeks mixing and matching the various conditions. What you’ll find is that there is always a higher prevalence, a definite link between them.


I’m going to use fibromyalgia in this mini-study to show that the link that RLS has with various inflammatory medical conditions is not unique. You can find similar links with any inflammatory condition – cancer, colitis, depression etc. but in this case I’m going to use fibromyalgia as the benchmark.

from “Restless legs syndrome and leg cramps in fibromyalgia syndrome: a controlled study.” (Yunus and Aldag, 1996).
“Our study shows an association between fibromyalgia syndrome and restless legs syndrome as well as leg cramps and confirms a previously reported association between rheumatoid arthritis and restless legs. The basis of this association is not clear. Fibromyalgia is not a psychiatric condition, and we found no association between restless legs syndrome and psychological state.”

from “Bipolar Disorder Common in Fibromyalgia” by Jessica Ward Jones, MD, MPH, Psych Central
“Many fibromyalgia patients may also suffer from bipolar disorder as well as depression. New research suggests that just over 25 percent of patients with fibromyalgia also have symptoms of bipolar disorder.”

from “7 Conditions Linked to Fibromyalgia” by
“A significant number of people with fibromyalgia also experience migraines and/or tension headaches, says Robert Duarte, MD, director of the Pain Institute at the North Shore–Long Island Jewish Health System, in Manhasset, N.Y.”

from “7 Conditions Linked to Fibromyalgia” by
“Irritable bowel syndrome (IBS) is marked by abdominal cramps and bouts of constipation and/or diarrhea. Between 30% and 70% of people with fibromyalgia have IBS too.”

from “Fibromyalgia and obesity: the hidden link” (Ursini et al. 2011).
“Epidemiological data show that Fibromyalgia patients have higher prevalence of obesity (40%) and overweight (30%) in multiple studies compared with healthy patients.”

inflammation1IN CLOSING

After reading the above data, hopefully you’ll come to understand that the link between RLS and other inflammatory conditions is not unique at all. This whole belief about there being a PRIMARY and SECONDARY RLS just isn’t real. It’s like saying there’s a PRIMARY and SECONDARY depression, or a PRIMARY and SECONDARY migraine.

I urge you to do your own research in this area. Take any pair of conditions that interest you from this list and do a search to see if they are knowingly linked.

Eventually you’ll realize, that without a doubt, there is growing inflammation beneath the surface that is causing this laundry list of conditions.

RLS is only one of its many faces.

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