RLS, Dopamine and Inflammation

Most RLS sufferers, and ALL Scientists and Doctors believe that my remedy for RLS is nothing but another example of the Placebo Effect in action. They insist that RLS has nothing to do with inflammation. Their most common guess states that RLS is due to a lack of dopamine production … with a secondary connection to low iron levels.

Doctors throw around the words “placebo effect” the same way that athiests throw around the word “coincidence.” They can’t explain something, so they beat it back into the dark with this never-failing label. In their minds, everything goes back to the way it was.

So, I had to do some more digging to prove to these people that there is a connection. I put on my detective hat and went back to the dark and scary world where the mice torturers torture the mice, to find if there is any sort of proven connection between dopamine levels and inflammation.

It turns out that there is a profound connection!

Below you’ll find scientific proof showing that inflammation has a direct negative effect on dopamine levels.

I also found scientific proof that most of the supplements in this RLS remedy help to stabalize or increase dopamine levels. And I found scientific proof (to no one’s surprise) that the most common RLS antagonists (gluten, sugar, msg etc.) ALL have a negative effect on dopamine levels.

You can read more about that here: http://www.rlcure.com/dopamine.html

From the Lab: SCIENTIFIC EVIDENCE PROVING THAT INFLAMMATION HAS A NEGATIVE EFFECT ON DOPAMINE LEVELS

“Why dopamine neurons are especially vulnerable to this inflammatory insult is still unknown. Dr. Glass noted that astrocytes and microglia are more concentrated in the substantia nigra than in other parts of the brain – it could just be a concentration effect, he said. It’s also possible that dopamine neurons are more sensitive to whatever toxic factors are produced. The culprit toxic molecules are still unknown, but there are plenty of candidates, including cytokines, death pathway triggers, and others. It’s a complicated problem to sort out.”

Richard Robinson, “To Protect Dopamine Neurons, Turn on Nurr1, Turn Off Inflammation.” Neurology Today: 21 May 2009 – Volume 9 – Issue 10 – pp 21,23. doi: 10.1097/01.NT.0000354539.50613.77

“Evidence suggests that chronic inflammation, mitochondrial dysfunction, and oxidative stress play significant and perhaps synergistic roles in Parkinson’s disease (PD), where the primary pathology is significant loss of the dopaminergic neurons in the substantia nigra.”

RL Hunter, N. Dragicevic, K. Seifert, DY Choi, M. Liu. HC Kim, WA Cass, PG Sullivan and G. Bing, “Inflammation induces mitochondrial dysfunction and dopaminergic neurodegeneration in the nigrostriatal system.” Journal of Neurochemistry. 2007 Mar;100(5):1375-86. Epub 2007 Jan 23.PMID: 17254027

“We tested the effects of inflammation on renal dopamine D1 receptor signaling cascade, a key pathway that maintains sodium homeostasis and blood pressure during increased salt intake. Inflammation was produced by administering lipopolysaccharide (LPS; 4 mg/kg ip) to rats provided without (normal salt) and with 1% NaCl in drinking water for 2 wk (high salt). Our results suggest that LPS differentially regulates NF-kappaB and Nrf2, produces inflammation, decreases antioxidant enzyme, increases oxidative stress, and causes D1 receptor dysfunction in the RPTs. The LPS-induced dysfunction of renal D1 receptors (dopamine receptor) alters salt handling and causes hypertension in rats during salt overload.”

M. Asghar, G. Chugh and MF Lokhandwala, “Inflammation compromises renal dopamine D1 receptor function in rats.” Am J Physiol Renal Physiol. 2009 Dec;297(6):F1543-9. Epub 2009 Sep 30. PMID: 19794106

“Children with ADD have a much higher Silent Inflammation Profile than normal children. Therefore, the problem of ADD is much more complicated than simply the lack of dopamine in the brain.”

Barry Sears, Ph.D., “Brain Drain Due to Silent Inflammation: ADD to Alzheimer’s Disease” The American Chiropractor (May 2006).

“Alterations in dopamine receptor function have been reported in human and rodent hypertension. Essential hypertension is associated with dopamine D2 receptor (D2R) gene polymorphisms that result in reduced D2R density. Mice with disruption of the D2R (D2-/) have elevated blood pressure. The D2Rs regulate the inflammatory reaction and are implicated in the pathogenesis of inflammatory diseases. We hypothesized that deficient D2R function increases the expression of pro-inflammatory cytokines and chemokines in the kidney and results in renal inflammation and injury that contribute to the development of high blood pressure. Our results show that the D2R, by mechanisms other than increased oxidant activity, regulates the expression of inflammatory factors in the kidney and suggest that altered D2R function may result in renal inflammation and injury.”

Ines Armando, Annabelle M. Pascua, Xiaoyan Wang, Yanrong Zhang, Van Anthony, M. Villar, Yu Yang, John E. Jones, Laureano Asico, Crisanto Escano and Pedro A. Jose, “Deficient Dopamine D2 Receptor Function Results in Renal Inflammation and Injury.” Children’s Rsch Institute- Children’s National Med Cntr, Washington, DC. (Circulation. 2009;120:S1165.)

“Several lines of evidence point to a significant role of neuroinflammation in Parkinson’s disease (PD) and other neurodegenerative disorders.”

Rosario Sanchez-Pernaute, Andrew Ferree, Oliver Cooper, Meixiang Yu, Anna-Liisa Brownell and Ole Isacson. “Selective COX-2 inhibition prevents progressive dopamine neuron degeneration in a rat model of Parkinson’s disease.” Journal of Neuroinflammation (2004). 1:6doi:10.1186/1742-2094-1-6

“A massive degeneration of dopamine-containing neurons in the substantia nigra (SN) in the midbrain is characteristic of Parkinson’s disease. Inflammation in the brain has long been speculated to play a role in the pathogenesis of this neurological disorder.”

Bin Liu, Jian-Wei Jiang, Belinda C. Wilson, Lina Du, San-Nan Yang, Jiz-Yuh Wang, Gen-Cheng Wu, Xiao-Ding Cao and Jau-Shyong Hong, “Systemic Infusion of Naloxone Reduces Degeneration of Rat Substantia Nigral Dopaminergic Neurons Induced by Intranigral Injection of Lipopolysaccharide” The Journal of Pharmcology and Experimental Therapeutics Vol. 295, No. 1, JPET 295:125-132, (2000).

For free information about the cause and cure for Restless Legs Syndrome visit www.RLcure.com This remedy for RLS is completely natural and features NO side effects.

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