Why There Will Never be a Drug that Can Cure Restless Legs Syndrome

ImageDoctors are a LOT smarter than I am. You don’t need me to tell you that.

The doctors and scientists that are interested in RLS have read the same scientific reports as I have. We have that in common.

The big difference is that THEY have read the reports through the eyes of a scientist – processing the information with a brilliant and logical mind that understands how the complex processes of the body work and all the terminology that goes with it.

In other words, they completely understand what’s being presented to them.

Therefore, it is not likely that I’m seeing something OBVIOUS that they are NOT seeing.

It would be clear to them that:

1. forty-one INFLAMMATORY diseases and conditions show a HIGHER prevalence of RLS
2. two demographics, pregnant women and the elderly, both have a HIGHER presence of inflammation and both have a HIGHER prevalence of RLS
3. the most notable triggers of RLS are ALL inflammatory
4. inflammation has a NEGATIVE effect on dopamine levels
5. inflammatory cytokines cause the brain to release HIGHER levels of glutamate
6. the most recommended solutions such as iron, potassium and magnesium ALL have anti-inflammatory properties

It would certainly be obvious to any doctor reading the Restless Legs studies, that without a doubt, inflammation is a primary factor.

ImageThese doctors would also be fully aware that there are currently no medical solutions for this problem.

They know that there are NO Nonsteroidal Anti-Inflammatory Drugs (NSAIDs) in existence that don’t have SEVERE side-effects with prolonged use. So, an anti-inflammatory drug is NOT an option for dealing with any inflammation-based ailment.

The doctors, scientists and pharmaceutical company’s hands are tied. They have no answer for inflammation. They can only watch helplessly as ENDLESS studies pour in that identify inflammation as a MAJOR PLAYER in hundreds of diseases and conditions.

Pharmaceutical executives must be salivating at the thought of being the first to develop a cure. A safe way to get rid of all that inflammation.

They know that if their company WAS able to produce a potent anti-inflammatory, that could heal inflammation without any dangerous side-effects, it would be applied to HUNDREDS of diseases and ailments!

Such a drug would be a UNIVERSAL PANACEA such as the world has never seen. It would not only wipe out RLS, it would be a MAJOR HEALER for hundreds of conditions, including cancer, Parkinson’s, ALS, depression, ADHD, all the “itis” conditions such as arthritis … and many more.

Just think how much they would make from arthritis alone.

It wouldn’t be a billion dollar drug for that company, it would be a TRILLION dollar drug.


Below you’ll find substantial proof that NSAIDs cannot be taken over a LONG period of time.

They are therefore NOT a viable solution for the MANY inflammatory diseases and conditions that are now known to exist. This includes Restless Legs Syndrome / Willis-Ekbom Disease.

from “Recent Considerations in Nonsteroidal Anti-Inflammatory Drug Gastropathy.”
Singh Gurkirpal, MD. The American Journal of Medicine, July 27, 1998, p. 31S

“Conservative calculations estimate that approximately 107,000 patients are hospitalized annually for nonsteroidal anti-inflammatory drug (NSAID)-related gastrointestinal (GI) complications and at least 16,500 NSAID-related deaths occur each year among arthritis patients alone.”

from the Washington Post “Consumer Reports: Overuse of pain relievers can be hazardous.” July 18, 2011

“5 to 10 percent of NSAID users experience ulcers or bleeding in a given year.”

from R. Morgan Griffin on WebMD

“There is no question that the risks of NSAIDs can be serious, even life-threatening. According to the American Gastroenterological Association (AGA), each year the side effects of NSAIDs hospitalize over 100,000 people and kill 16,500 in the U.S., mostly due to bleeding stomach ulcers.

But the problem with NSAIDs — or any systemic drug — is that they can affect the entire body, not just the part that hurts.

“If you use a drug to ease one problem, like an achy joint,, it’s likely to cause a different reaction somewhere else too.”

Imagefrom The New York Times “Experts Warn Against Long-Term Use of Common Pain Pills.” by Roni Caryn Rabin, May 6, 2009

“Last week, an expert panel of American Geriatrics Society pretty much bumped all non-steroidal anti-inflammatory drugs, or NSAIDs, off the list of medicines recommended for adults ages 75 and older with chronic, persistent pain. Long-term use of drugs like ibuprofen, naproxen and high-dose aspirin is so dangerous, the panelists said, that elderly people who can’t get relief from alternatives like acetaminophen may be better off taking opiates, like codeine or even morphine.

The risks from chronic use of NSAIDs are myriad. They can cause life-threatening ulcers and gastrointestinal bleeding, a side effect that occurs more frequently and with greater severity as people age. Some NSAIDs may increase the risk for heart attacks or strokes, and they don’t interact well with drugs used to treat heart failure. They can make high blood pressure worse, even uncontrollable, and impair kidney function. And the list of potentially hazardous interactions with other drugs is a long one, experts say.”

from the Chicago Tribune “Patients in pain keep popping pills despite FDA warning.” by Bruce Japsen, April 11, 2005

“Despite sweeping new warnings that the nation’s most popular painkillers can harm hearts, stomachs and skin, many Americans are going to go right on taking them, saying the relief is worth the risk.

The popular arthritis drug Bextra last week became the second Cox-2 painkiller pulled from the market, while the Food and Drug Administration pinned its highest warnings on Celebrex and nearly 20 other common prescription-strength drugs such as Mobic, Motrin, Naprosyn and ibuprofen.”

from Consumer Reports “The Nonsteroidal Anti-Inflammatory Drugs: Treating Osteoarthritis and Pain.”

“Studies show that NSAIDs are effective pain relievers, but they have serious risks. When used at high doses for long periods, most increase the risk of heart attacks and strokes. NSAIDs also have other risks, such as increasing blood pressure, causing fluid retention, and reducing kidney function.

It is well known that oral NSAIDs can cause life-threatening gastrointestinal bleeding, usually from the stomach. The risk increases with age, which is important to note because the majority of people who take NSAIDs for long periods are 60 years or older.”

from “About.com 9 Ways to Reduce Your Risk of Bleeding Ulcers from NSAID Use.” by Carol Eustice, August 26, 2008

“Bleeding typically occurs from the duodenum or stomach, but may also develop from the large intestine. While warning signs often occur, such as stomach discomfort or bloody/black stools, some patients — especially the elderly — may have no warning before they develop serious bleeding.”

Image“Omega-3 fatty acids (fish oil) as an anti-inflammatory: an alternative to nonsteroidal anti-inflammatory drugs for discogenic pain.”
Maroon JC, Bost JW. Department of Neurological Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA

“The use of NSAID medications is a well-established effective therapy for both acute and chronic nonspecific neck and back pain. Extreme complications, including gastric ulcers, bleeding, myocardial infarction, and even deaths, are associated with their use.”

from PureHealthMD “NSAIDs”

“NSAID use is known to pose risk for congestive heart failure and increase chances for admission. This is a concern since someone could easily take an ibuprofen for a bad headache without realizing that it could seriously upset their fluid balance. NSAIDS can increase the risks associated with blood pressure as well. Complications from increased blood pressure and kidney problems are especially pronounced in the elderly. “

from “Pain Relievers and the Risk of Hearing Loss.” by Sharon G. Curhan, MD, MSc

“Many of the harmful effects of NSAIDs are related to their primary mechanism of action, through the inhibition of prostaglandins. They can cause gastrointestinal problems such as dyspepsia, ulcers and bleeding, be toxic to the kidneys, increase the risk of bleeding, have adverse nervous system and cardiovascular effects, and interfere with the cardioprotective benefits of aspirin. Too much acetaminophen can cause serious liver damage and can be particularly harmful in combination with alcohol. NSAIDs and acetaminophen can increase the risk of high blood pressure and interact adversely with other medications.”

from “Harmful effects of NSAIDs among patients with hypertension and coronary artery disease.” Bavry AA, Khaliq A, Gong Y, Handberg EM, Cooper-Dehoff RM, Pepine CJ. Department of Medicine, College of Medicine, University of Florida, Gainesville. Am J Med. 2011 Jul;124(7):614-20. doi: 10.1016/j.amjmed.2011.02.025. Epub 2011 May 18.

“Among hypertensive patients with coronary artery disease, chronic self-reported use of NSAIDs was associated with an increased risk of adverse events during long-term follow-up.”

Imagefrom The Medical Observer “Least harmful NSAID for cardiovascular patients identified.” by Kirrilly Burto, 17th Jan 2011

“A meta-analysis of 31 randomised trials, in more than 116,000 patients with osteoarthritis and rheumatoid arthritis, found little evidence any of the commonly used NSAIDs for pain management were safe in cardiovascular terms compared with placebo.

The drugs analysed were naproxen (Naprosyn), ibuprofen (Nurofen), diclofenac (Voltaren), celecoxib (Celebrex), etoricoxib (Arcoxia), rofecoxib (Vioxx) and lumiracoxib (Prexige).

Patients taking rofecoxib and lumiracoxib had twice the risk of myocardial infarction compared to people taking placebo.”

“Our study confirms previous notions of regulatory bodies, mainly based on observational evidence, that all non-steroidal anti-inflammatory drugs are associated with an increased risk of cardiovascular adverse effects,” the authors said.

Ibuprofen was associated with the highest risk of stroke, accounting for a threefold risk of having a stroke.

Both etoricoxib and diclofenac were associated with the highest risk of cardiovascular death, with around a fourfold risk.”

from “Acetabular bone destruction related to non-steroidal anti-inflammatory drugs.” Newman NM, Ling RS. Lancet. 1985 Jul 6;2(8445):11-4.

“In a retrospective investigation of the relation between use of non-steroidal anti-inflammatory drugs (NSAIDs) and acetabular destruction in primary osteoarthritis of the hip, 70 hips were studied in 64 patients. Cranial acetabular migration, a measure of acetabular destruction, was present in 37 hips and absent in 33. Regular intake of NSAIDs was noted for 31 of the 37 migrating hips and irregular intake for a further 3. Among the 33 non-migrating hips, the corresponding numbers were 7 and 5, respectively. This highly significant association between NSAID use and acetabular destruction gives cause for concern, not least because of the difficulty in achieving satisfactory hip replacements in patients with severely damaged acetabula.”

Imagefrom The Guardian “Ibuprofen warning to pregnant women.” Tuesday 6 September 2011

“Women who take even a small dose of painkillers such as ibuprofen early in their pregnancy more than double their risk of suffering a miscarriage, research shows.”


ImageChronic inflammation is the result of a particular lifestyle choice or environmental situation. It’s not something a pill can fix.

There’s no drug that’s ever going to clean up the mess of 20 years of hard drinking, or a lifetime’s worth of eating potato chips.

The damage created from the inflammation needs to be attended to, but more importantly, the SOURCE of that inflammation needs to be ALTERED.

Otherwise, you’re only going to continue feeding the fire, and increase the amount of inflammation that is burning inside of you. And with that comes a more intense twitching.

What you need to ask yourself is HOW did this inflammation come into existence?

Once you figure that out, you can then work on moving away from the source(s).


  1. Elsa Nilsson said

    Oh! Why do you always use such a bid amount of words? It is nearly impossible to read, it ist to much at the time. Why can’t you write short and effective messages?
    I have to unsuscribe.

    • rlsottawa said

      Hi Elsa
      Sorry to see you go. The core of all my writing is on the the “Absolute Cure” page
      http://www.rlcure.com/daily.html That’s all you really need to know,

      And remember the formula “Less Inflammation = Less Restless Legs”

      The rest is all window dressing.

  2. Then please answer the question.What you need to ask yourself is HOW did this inflammation come into existence? How does one move away from the source? Once you figure that out, you can then work on moving away from the source(s).

    • rlsottawa said

      I’m not quite sure what your question is? This whole website is about what causes inflammation, and how to get rid of it. Is there something specific you were wondering about?

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