“Epidemiological studies report a 2- to 4-fold risk of a depressive disorder in patients with restless legs syndrome (RLS) compared with healthy controls. The high prevalence rates of depression in RLS indicate an association between the two disorders.”
“Depressive disorders in restless legs syndrome: epidemiology, pathophysiology and management.” Hornyak M. CNS Drugs. 2010 Feb;24(2):89-98. doi: 10.2165/11317500-000000000-00000.
“Lifetime prevalence of any psychiatric disorders was 36.8% among participants with restless legs syndrome and was substantially higher than in participants without restless legs syndrome (14.6%). Among the psychiatric diagnoses, DSM-IV major depressive disorder was the most common diagnosis with a lifetime and 12-month prevalence of 19.0% (n=8) and 9.5% (n=4) among participants with restless legs syndrome.”
“Restless Legs Syndrome is Associated with DSM-IV Major Depressive Disorder and Panic Disorder in the Community.” Hochang B. Lee, M.D.; Wayne A. Hening, M.D, Ph.D.; Richard P. Allen, Ph.D.; Amanda E. Kalaydjian, Ph.D.; Christopher J. Earley, M.B.B.Ch., Ph.D.; William W. Eaton, Ph.D.; Constantine G. Lyketsos, M.D., M.H.S. The Journal of Neuropsychiatry and Clinical Neurosciences 2008;20:101-105.
“Inflammations that are hidden inside your body as a result of disease or an unhealthy lifestyle do not only damage your physical body. It appears that they can also affect your mental state by triggering a depression. Higher-than-normal blood levels of C-reactive protein (CRP), an indicator of inflammatory disease, increase the risk of depression two- to threefold, according to a comprehensive new Danish study.
“The risk of inflammation increases with an unhealthy lifestyle, obesity and chronic diseases. Our message to the public is that one should avoid getting into situations that increase inflammatory protein levels in the body” says lead researcher Dr Borge Nordestgaard, of Copenhagen University Hospital.”
ScienceNordic “Inflammation can cause depression: Inflammation in the body gives a two- to threefold risk of depression.” by Sybille Hildebrandt, January 6, 2013. sciencenordic.com/inflammation-can-cause-depression
“Many studies show that people with depression have higher measures of various inflammatory markers in the blood than people who are not depressed (Howren MB et al., Psychosom Med 2009;71(2):171–186).”
Psych Central “Inflammation and Depression” by Charles Raison, MD. (10 Sep 2013). pro.psychcentral.com/2013/this-months-expert-inflammation-and-depression-by-charles-raison-md/004282.html#
“Mounting evidence indicates that inflammation may play a significant role in the development of depression. Patients with depression exhibit increased inflammatory markers, and administration of cytokines and other inflammatory stimuli can induce depressive symptoms.”
“Inflammation in depression: is adiposity a cause?: Shelton RC, Miller AH. Dialogues Clin Neurosci. 2011;13(1):41-53.