Archive for RLS and Inflammation

Dr. Stanley Lang, MD has a 90% Success Rate Treating RLS Patients over a 30 Year Period

Over 30 years ago Dr. Stanley Lang, MD developed a program to treat RLS and has been helping his patients to heal their RLS ever since (starting way back before the condition had an actual name).

His success rate is around 90% for those patients that have followed his regime.

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Quote from Dr. Leonard Weinstock, MD, About the Relationship Between Inflammation and Restless Legs Syndrome

“I have thoroughly analyzed every known scientific study that has been done on Restless Legs Syndrome. Taking all of this data into consideration, there is no doubt in my mind that inflammation plays a major role in the occurrence of RLS. I see this time and time again with many patient types.”

– Dr. Leonard Weinstock, MD, Specialist In Gastroenterology, St. Louis, MO

quote-from-doctor-leonard-weinstock-about-restless-legs-syndrome

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Why is the POWERFUL Link Between Restless Legs Syndrome and Inflammation Being Ignored? (PART TWO)

Puzzled male shrugging wearing lab coatIn PART ONE of this article I listed how several inflammatory conditions have been tested to have a higher prevalence of Restless Legs Syndrome. Yet the idea of inflammation being the common link is completely ignored.

As a medically uneducated person, if I was faced with a question on an exam that stated “There are forty inflammatory conditions that show a higher prevalence of Restless Legs Syndrome. Based on this information, what do you think may be causing the legs to be restless?”

a) abnormal use of iron by the brain
b) dopamine receptors are not signalling correctly
c) medications
d) inflammation

The dumb me would think, “well, if they’re all inflammatory conditions, I’m going to take a wild guess and say that the common link is d) inflammation.”

However, I would be wrong. In fact, according to science ALL the answers are right, except mine.

So despite my stifling ignorance, I present to you more evidence of the unshakeable link between inflammation and Restless Legs Syndrome.

Please visit The Healthy Elephant to read the rest of this article:
http://www.thehealthyelephant.com

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“Why is the Powerful Link Between Restless Legs Syndrome and Inflammation Being Ignored?” (PART ONE)

new-THE-pic-2013-186x300A very special thanks to Laurie Boucino of “The Healthy Elephant” for publishing my article about RLS and inflammation.

In this article I’ve taken all the evidence I’ve compiled from researching scientific studies and packed it into a single article. It will hopefully sway even the most devote skeptic. Elephant-elephants-28788752-1024-768 You can view PART ONE of the article at the Healthy Elephant website ww.thehealthyelephant.com

The Healthy Elephant website was created in order to guide people to wellness and personal healthcare empowerment  through education.

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Your Restless Legs are a WARNING SIGNAL!

warning-signal-restless-legs-syndromeI’m going to keep repeating this mantra for as long as it takes because it’s CRUCIAL for people suffering from RLS to understand that the twitching and rustling of their legs is a SYMPTOM of a DEEPER issue that needs to be addressed.

That issue being the presence of chronic inflammation

If the inflammation is not attended to, it will eventually manifest as a REAL disease or condition, one that is CERTAIN to affect your quality of life.

You don’t have to disobey your doctor. You can change your diet and add in some vitamins and supplements and still take your RLS and sleep medications. So, there’s no downside in making these changes.

For more information please visit this link:

http://www.rlcure.com/restless-legs-syndrome-willis-ekbom-is-not-a-disease.html

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What is a Cure?

quote-the-art-of-medicine-consists-in-amusing-the-patient-while-nature-cures-the-disease-voltaire-191207I’ve stated many times on my website and social media pages why I call my remedy “An Absolute CURE for RLS.”

I call it an “ABSOLUTE” cure, because it is.

If you find out what is causing the inflammation in your body and begin to replace that with a healthier option, your RLS symptoms will lessen. This is guaranteed.

The more you lessen the inflammation in your body the more your RLS will lessen.

If you religiously follow an anti-inflammatory regime, and are able to eliminate the main sources of your chronic inflammation (whether it be stress, diet, environment, food intolerance etc.) you will eventually become free of RLS.

Once that occurs, then by definition (according to four of the world’s most popular dictionaries) that indicates that you have found a “cure” for your RLS.

OxfordOxford Dictionary
“Relieve a person or animal of the symptoms of a disease or condition.”

Merriam-Webster Dictionary
“Something that stops a disease and makes someone healthy again.”

Cambridge Dictionary
“To make someone healthy again, or to cause an illness to go away.”

Scrabble Dictionary
“Restore to health.”

At some point in time the Medical Community hijacked the word “cure” and made it their own. In their minds the only cure is one that eliminates a condition or disease through drugs.

This rigid interpretation of the word is not accurate. As the definitions above state, ANY way that you are able to eliminate your condition, is considered a cure.

It’s kind of ironic when you think about it. When is the last time you heard about a new drug on the market that actually cured something?

“Drugs are powerful tools when they are not overused, but the notion of simple drug fixes is fundamentally flawed. Every BruceLiptontime a drug is introduced into the body to correct function A, it inevitably throws off function B, C or D.” – Bruce Lipton, author of “The Biology of Belief”

HERE ARE SOME OTHER QUOTES FROM THROUGHOUT HISTORY ABOUT PHARMACEUTICAL DRUGS:

“Medicines are of subordinate importance because of their very nature they can only work symptomatically.” – Hans Kusche, M.D.

Oliver-Wendell-Holmes-Sr“If all the medicine in the world were thrown into the sea, it would be bad for the fish and good for humanity” – O.W. Holmes, (Prof. of Med. Harvard University)

“Every drug increases and complicates the patients condition.” – Robert Henderson, M.D.

“Doctors give drugs of which they know little, into bodies, of which they know less, for Diseases of which they know nothing at all.” – Voltaire

“Drugs never cure disease. They merely hush the voice of nature’s protest, and pull down the danger signals she erects along the pathway of transgression. Any poison taken into the system has to be reckoned with later on even though it palliates present symptoms. Pain may disappear, but the patient is left in a worse condition, though unconscious of it at the time.” – Daniel. H. Kress, M.D.

“It’s supposed to be a secret, but I’ll tell you anyway. We doctors do nothing. We only help and encourage the doctor Schweitzer_bigwithin.” – Albert Schweitzer, M.D.

“The greatest part of all chronic disease is created by the suppression of acute disease by drug poisoning.” – Henry Lindlahr, M.D.

“Every educated physician knows that most diseases are not appreciably helped by medicine.” – Richard C. Cabot, M.D. 200px-Picture_of_Richard_Clarke_Cabot(Mass. Gen. Hospital)

“The physician should not treat the disease but the patient who is suffering from it.” – Maimonides

“Medicine is only palliative, for back of disease lies the cause, and this cause no drug can reach.” – Wier Mitchel, M.D.

“Medical practice has neither philosophy nor common sense to recommend it. In sickness the body is already loaded with impurities. By taking drug – medicines more impurities are added, thereby the case is further embarrassed and harder to cure.” – Elmer Lee, M.D., Past Vice President, Academy of Medicine.

“The doctor of the future will no longer treat the human frame with drugs, but rather will Cure and prevent disease with nutrition.” – Thomas Edison

York Hospital Physician Photo Shoot“The necessity of teaching mankind not to take drugs and medicines, is a duty incumbent upon all who know their uncertainty and injurious effects; and the time is not far distant when the drug system will be abandoned.” – Charles Armbruster, M. D.

“We must admit that we have never fought the homeopath on matters of principle. We fought them because they came into our community and got the business.” – Dr. J.N. McCormack

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Restless Legs Symptoms Lessened with D-ribose

ATP_moleculeWhenever I run across something that has helped lessen a person’s RLS symptoms, whether it be a personal story or through a study, I know with 100% certainty that if I do a search on whatever it is they took to lessen their symptoms, that healing ingredient will have proven anti-inflammatory properties.

Such is the case with D-Ribose.

“D-Ribose is a naturally occurring five-carbon monosaccharide that is found in all living cells, and has anti-inflammatory effects in renal ischemia/reperfusion injury” (Ueki et al. 2013).

“D-ribose has anti-inflammatory activities and protects against damage mediated via inflammation.” from “D-ribose for energizing brain, autism and ADD/ADHD” by Dr. Anil Minocha, Board certified in Internal Medicine, Gastroenterology and Nutrition

I ran across a RLS study that was done in 2008 that showed great promise in a father and son with Restless Legs that were both given D-ribose.

I am going to post the results of the study followed by some basic information about what D-ribose is.

I realize in the great theater of science that this study doesn’t prove anything. However, to someone still suffering from RLS that is trying to find the slightest glimmer of hope, this is yet more evidence shining its light on the DIRECT LINK between RLS and INFLAMMATION.

STUDY: “D-ribose benefits restless legs syndrome.” (Shecterle et al. 2008).400x250xheart.jpg.pagespeed.ic.8Q2L_vwUPa

We report on two affected male individuals, a father and son, ages 71 and 47, from a family in which three generations carry the diagnosis. To evaluate any potential benefit of D-ribose in this condition, each individual orally consumed 5-g doses of D-ribose daily at different trial stages. Each stage lasted 3 weeks with a 2-week washout period between stages.

The initial stage involved a single 5 gm dose of D-ribose consumed at breakfast. Throughout the second stage, D-ribose was taken at breakfast and lunch. In the third stage, D-ribose was taken at all meals, breakfast, lunch, and dinner. Diaries by the subjects pertaining to their documentation and severity of restless legs syndrome symptoms was compiled. During the initial stage both men reported a general feeling of more energy and less fatigue, most notably after exercise, without any significant changes in their symptoms.

With the increase in the daily dose of D-ribose, in the second stage, their leg twitching and the feeling to move during the day was reduced for 1 subject, and rarely present in the other. Both still experienced the unpleasant sensations during the night.

However, during the final stage, a further increase in the daily dose of D-ribose eliminated their daily symptoms and the symptoms at night were of a lesser degree and had a later occurrence. Both men reported that D-ribose did not totally eliminate their discomfort, but the severity and onset of symptoms affecting their quality of life was substantially improved with D-ribose without any adverse reactions.

Jacob-Teitalbaum-Photo“D-Ribose–The Natural Body Energizer” from “Fatigued to Fantastic!” by Jacob Teitelbaum, M.D. (2007)

In looking at energy production, it helps to look at the “energy molecules” such as ATP, NADH, and FADH. These represent the energy currency in your body, and are like the paper that money is printed on. You can have all the fuel you want, but if it cannot be converted to these molecules, it is useless!

For years, I talked about the importance of B vitamins, which are a key component of these molecules. These helped to a degree, but it was clear that a key component was missing. In looking at the biochemistry of these energy molecules, they are also made of 2 other key components-adenine and ribose. Adenine is plentiful in the body and supplementing with adenine did not help CFS. We then turned our attention to Ribose. Ribose is made in your body in a slow, laborious process and cannot be found in food. We knew that CFS/FMS causes your body to dump other key energy molecules like acetyl-l-carnitine. We then found that the body did the same with Ribose, making it hard to get your furnaces working again even after the other problems were treated.

This was like one of those “Eureka!” moments where things came together. Not having Ribose would be like trying to build a fire without kindling—nothing would happen. We wondered if giving Ribose to people with CFS would jump-start their energy furnaces. The answer was a resounding yes!

Our recently published study (see the study abstract in Appendix B) showed an average 44.7% increase in energy after only 3 weeks (improvement began at 12 days) and an average overall improvement in quality of life of 30%. Two thirds of the CFS/FMS patients felt they had improved.19 Usually a 10% improvement for a single nutrient is considered excellent. A 44.7% increase left us amazed, and I am now recommending Ribose for all of my CFS/FMS patients, for athletes, and any one with pain, fatigue or heart problems. Ribose recently became available (over the counter) to physicians, and is one of the few natural products actually starting with physicians and then moving out into health food stores.

It is critical to use the proper dose for the first 3 weeks, which is 5 grams (5000 mg) three times a day. It can then be dropped to twice a day. I recommend the Corvalen form of ribose as it is the least expensive and highest quality and is packaged with a 5 gm dosing scoop in it. One 280 gm container will be enough to tell you if it will work. Corvalen M (which has ribose plus magnesium and malic acid) is also available, but if you are also taking the Energy Revitalization System vitamin powder (see chapter X), you are already getting the magnesium and malic acid, and the regular Corvalen is a better deal financially. Bioenergy, which makes Corvalen, also conducts almost all of the research on Ribose, knows the most about it, and has outstanding customer service in case you have any questions. Because of its importance, it’s worth looking at energy production and Ribose in greater detail. Having had the chance to explore the research and speak with a number of the researchers, below is what I’ve learned from them.

D-Ribose Accelerates Energy RecoveryRiboseChart2

D-Ribose (which is what I am referring to when I say ribose) is a simple, five-carbon sugar (known as a pentose by biochemists) that is found naturally in our bodies. But ribose is not like any other sugar. Sugars we are all familiar with, such as table sugar (sucrose), corn sugar (glucose), milk sugar (lactose), honey (predominantly fructose), and others are used by the body as fuel. These sugars are consumed and, with the help of the oxygen we breathe, are “burned” by the body to recycle energy. Because they are used excessively, they can also be toxic, as we’ve discussed earlier. Ribose, on the other hand, is special. When we consume ribose, the body recognizes that it is different from other sugars and preserves it for the vital work of actually making the energy molecule that powers our hearts, muscles, brains, and every other tissue in the body.

A key molecule, called adenosine triphosphate (or ATP for short), is known as the energy currency of the cell because the amount of ATP we have in our tissues determines whether we will be fatigued, or will have the energy we need to live vital, active lives. Ribose provides the key building block of ATP, and the presence of ribose in the cell stimulates the metabolic pathway our bodies use to actually make this vital compound. If the cell does not have enough ribose, it cannot make ATP. So, when cells and tissues become energy starved, the availability of ribose is critical to energy recovery.

Normal, healthy heart and muscle tissue has the capacity to make all the ribose it needs. When normal tissue is stressed by overexertion, several days of rest will usually allow it to fully recover. The muscle may be sore during recovery, as we frequently see for the three or four days after a hard day of yard work or after a weekend pick up football game, but eventually energy levels will be restored and the soreness will disappear. But when the muscle is chronically stressed by disease or conditions that affect tissue energy metabolism, the cells and tissues simply cannot make enough ribose quickly enough to recover. Hearts and muscles just don’t have the metabolic machinery they need to make ribose very efficiently. The result is chronic, persistent pain, stiffness, soreness, and overwhelming fatigue that may never go away.
The Link between Ribose, Energy, and Fatigue

Clinical and scientific research has repeatedly shown that giving ribose to energy deficient hearts and muscles stimulates energy recovery. One important study involved healthy athletes participating in high-intensity, endurance exercise over the course of one week. After exercise the energy level in the athlete’s muscle was reduced by almost 30%. Giving 10-grams of ribose per day for three days following exercise restored muscle energy levels to normal, while treatment with placebo provided virtually no effect.20 This study clearly showed that ribose stimulated the energy recovery pathways in the body, helping the muscle rebuild its energy supply quickly and completely. Even after three days of rest, muscle that was not treated with ribose remained energy starved and fatigued.

Two very interesting studies in animals showed how dramatic the effect of ribose could be on energy recovery in fatigued muscle. These studies were conducted by Dr. Ron Terjung, one of the top muscle physiologists in the U.S. In their research, Dr. Terjung and his co-investigators found that ribose administration in fatigued muscle increased the rate of energy recovery by 340% to 430%, depending on which type of muscle was tested.21 He also found that even very small amounts of ribose had the effect of helping the muscle cell preserve energy, a process known as energy salvage, and the higher the ribose dose, the more dramatic the effect on energy preservation.22 Although this groundbreaking research was done in animals it was instrumental in defining the biochemistry and physiology associated with the use of ribose in overcoming heart and muscle fatigue. But most of us with CFS and FMS are neither top athletes nor animals, so the question remains, “How will ribose affect me?”

D-Ribose-ArticleResearch in Ribose and CFS/FMS began with a case study that was published in the prestigious journal Pharmacotherapy in 2004.23 This case study told the story of a veterinary surgeon diagnosed with fibromyalgia. For months, this dedicated doctor found herself becoming more and more fatigued, with pain becoming so profound she was finally unable to stand during surgery. As a result, she was forced to all but give up the practice she loved.

Upon hearing that a clinical study on ribose in congestive heart failure was underway in the university where she worked, she asked if she could try the ribose to see if it might help her overcome the mind-numbing fatigue she experienced from her disease. After three weeks of ribose therapy she was back in the operating room, practicing normally with no muscle pain or stiffness, and without the fatigue that had kept her bedridden for many months.

Being a doctor, she was skeptical, not believing that a simple sugar could have such a dramatic effect on her condition. Within two weeks of stopping the ribose therapy, however, she was out of the operating room and back in bed. So, to again test the theory, she began ribose therapy a second time. The result was similar to her first experience, and she was back doing surgery in days. After yet a third round of stopping (with the return of symptoms) and starting (with the reduction of symptoms) the ribose therapy, she was convinced, and has been on ribose therapy since that time.

I found this report intriguing and decided to design the larger study in patients with fibromyalgia or chronic fatigue syndrome which I began to discuss earlier. Along with two research collaborators, I recently published a scientific paper describing the results of this research. The study we designed was intended to determine whether or not ribose would be effective in relieving the overwhelming fatigue, pain, soreness, and stiffness suffered by patients having this debilitating condition. Our study included 41 patients with a diagnosis of fibromyalgia or chronic fatigue syndrome who were given ribose at a dose of 5-grams three times per day for an average of three weeks. We found the ribose treatment led to significant improvement in energy levels, sleep patterns, mental clarity, pain intensity, and well being. Of the patients participating in the study, 65.7 % experienced significant improvement while on ribose, with an average increase in energy of 44.7% and overall well being of 30%- remarkable results from a single nutrient! 19 The only significant side effects were that 2 people felt too energized and hyper/anxious on the ribose. This is simply dealt with by lowering the dose and/or taking it with food.

To further validate these findings, we are currently conducting a much larger placebo controlled study, and hope to have theimages results published in the coming year. Interestingly, one of our study patients had an abnormal heart rhythm called atrial fibrillation. Ribose is outstanding in the treatment of heart disease as well, because it restores energy production in the heart muscle. Because of this, it was not surprising that this man’s atrial fibrillation also went away on the ribose and he was able to stop his heart medications as well! Because of its importance and the research showing marked heart muscle dysfunction (because of low energy) in CFS, let’s look at Ribose and the heart in more detail.

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