Posts Tagged marijuana

How To Overcome Restless Leg Syndrome Naturally (By Healing The Gut) by Jordan Reasoner, SCDLifestyle

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Sleep is important (we all know this) … but just how important is it?

Poor sleep is associated with increased depression, anxiety, systemic inflammation and decreased immune function.

For those with Restless Leg Syndrome, a lack of sleep is likely a nightly occurrence. It’s also the most dangerous side effect of this frustrating condition.

Worse yet, many suffer from Restless Leg Syndrome and don’t know it.

RLS can often be misdiagnosed as another sleep disorder, depression, poor circulation, arthritis, back problems and even growing pains in children.

If you have extreme fatigue, trouble falling or staying asleep, depression or anxiety, take the time to keep reading.

WHAT IS RESTLESS LEG SYNDROME?choice

Restless Leg Syndrome (RLS) is a neurological condition characterized by an uncomfortable feeling in the legs (most commonly). The unpleasant feeling causes an intense urge to move the lower extremity in order to find relief. The sensation is more prominent at night and is often described as “bugs crawling up the legs.”

The side effects of RLS are more concerning than the condition itself, and include:

Insomnia
Extreme daytime fatigue
Increased use of sleeping medications or alcohol to sleep
Increased use of stimulants in order to function
Increased stress (likely due to lack of sleep) and anxiety

Restless Leg Syndrome, also known as Willis-Ekbom Disease or WED, is most common in middle to older-age women, although anyone can experience it. The National Sleep Foundation estimates up to 10% of adults suffer from RLS.

confused-doctorHOW IS RLS DIAGNOSED?

The International Restless Leg Syndrome Study Group requires the following clinical features to be present in order to confirm a diagnosis of RLS:

Strong urge to move the legs due to uncomfortable sensations in the leg(s)
Symptoms become worse during periods of rest or inactivity
Symptoms are partially or totally relieved by movement
Symptoms become worse in the evening or nighttime
Symptoms are not solely accounted for by another condition (i.e leg cramps, positional discomfort)

Perhaps the most important tool, though not always performed, is a test to determine your iron levels. The most accurate way to determine if iron deficiency plays a role in RLS is to measure ferritin. Ferritin is an iron binding protein in which low values (less than 50 ng/ml) indicate low iron storage in the brain (more on iron below).

IS RLS A GENETIC CONDITION?

First degree relatives are 3 to 6 times more likely to suffer from the condition and over 50 percent of affected individuals report having at least one immediate relative with the condition.

Studies suggest when children experience RLS (early onset) it is more likely due to genetics as opposed to onset later in life (after the age of 45). Several gene variations have been studied as possible contributors to RLS, including the following genomic regions: BTBD9, MAP2K5, MEIS1, PTPRD, SKOR1 and TOX3.

Risk allele BTBD9 is associated with RLS and decreased peripheral iron stores – a well-defined environmental factor in which the risk of RLS is about 9 times greater than the general populations.

A change in the BTBD9 gene is present in about 75% of patients who have RLS but also present in about 65% of patients who don’t have RLS…

The difference? Environmental factors.

It’s the environmental triggers in combination with the right genes that trigger Restless Leg Syndrome.

Genetics alone rarely tell the whole story (and that holds true for each of the autoimmune conditions we’ve covered).

TRIGGERS FOR RESTLESS LEG SYNDROMEtriggers-01

Caffeine – Caffeine, most commonly found in coffee, tea, chocolate, and soda may aggravate the symptoms of RLS. For many, caffeine activates excitatory neurotransmitters and has an arousal effect on the central nervous system. Ultimately, it’s effects promotes motor activity and inhibits proper control of fine motor movements, worsening the symptoms of RLS.

Iron Deficiency – The most consistent finding and the strongest environmental risk factor associated with RLS is iron insufficiency. Studies suggest that restless leg syndrome is related to a deficiency of iron in certain parts of the brain despite normal levels in the blood. (See information on testing iron in the diagnosis section.)

Vitamin D Deficiency – One of the most common theories about the cause of RLS is impaired dopamine signaling, and vitamin D is now being researched for its role in this process. Several studies support the hypothesis that a deficiency of Vitamin D correlates with more frequent and more severe symptoms of RLS.

Diet – Vitamin B12 is a critical part of a healthy nervous system, helping to maintain and protect the myelin sheath around the nerves. Researchers are led to believe it could play a role in the onset and treatment of RLS, due to its central role in our nervous system and brain.

A study published in the Journal of Postgraduate Medicine found both iron and vitamin B12 deficiencies to be common and treatable cause of RLS.

The best dietary sources of Vitamin B12 come from beef liver, grass-fed beef and eggs. But in order to absorb Vitamin B12, we must have adequate stomach acid levels and a healthy gut.

Stress – Chronic stress can alter cortisol production and lead to nighttime cortisol release, which researchers have found to be correlated with RLS. Stress levels can also decrease dopamine in the brain – a neurotransmitter necessary for smooth muscle activity and movement. When dopamine is decreased in the brain, it may cause movement problems seen in Parkinson’s disease and RLS.

Pregnancy – The prevalence of RLS during pregnancy is two to three times higher than in the normal population. Hormonal changes and iron status are the two main factors that may contribute to RLS during pregnancy.

Researchers have discovered another piece to the puzzle in the onset of RLS – systemic inflammation.

sysesdefaultSYSTEMIC INFLAMMATION – THE CAUSE OF RESTLESS LEG SYNDROME?

What if the cause of those frustrating leg twitches is something you can’t see or touch… and is rarely a diagnosis you’d receive at the doctor’s office?

We’re talking about systemic inflammation (inflammation relating to the whole body).

54 diseases, syndromes and conditions have been reported to cause and/or exacerbate RLS – all interconnected by inflammation.

The fact that 89% of RLS-associated conditions are associated with inflammation and/or immune changes have led researchers to develop 2 possible theories in the RLS – Inflammation connection:

Systemic inflammation can contribute to an iron deficiency in the brain:

Inflammation can lead to the production of IL-6, an inflammatory cytokine which can stimulate hepcidin production.

Hepcidin is the main hormone involved in the regulation of iron and increased levels can lead to decreased serum iron levels. The result? Decreased availability of iron to the brain.

Systemic inflammation can trigger autoimmune disorders associated with RLS.

RLS is associated with Multiple Sclerosis, Rheumatoid Arthritis, Sjögrens syndrome, Scleroderma, Celiac disease and Crohn’s disease – all autoimmune diseases plagued by systemic inflammation.

RLS is present in up to one third of MS cases and is also common in those with Crohn’s disease – a disease associated with iron deficiency, inflammation, and bacterial overgrowth. One study of 272 Crohn’s disease patients found 30% were affected by RLS.

The bottom line is this – we have to address the factors in our life that cause inflammation and the best place to start is a damaged gut.

A LEAKY GUT – THE MISSING LINK IN RESTLESS LEG SYNDROME?leakystory

You might wonder what the gut has to do with that uncomfortable feeling in your legs.

A damaged or leaky gut is a breeding ground for inflammation – the very inflammation that can lead to RLS.

A leaky gut allows conditions like SIBO (small intestine bacterial overgrowth), and irritable bowel syndrome (IBS) to wreak havoc on the body and contribute to things like RLS.

One study found 69% of RLS patients had SIBO while 28% also suffered from IBS symptoms (i. e. gas, cramping, bloating, and changes in bowel habits).

SIBO can lead to systemic inflammation and autoimmune changes (which can result in the nerves being attacked in RLS) and SIBO induced inflammation can increase hepcidin (the main hormone responsible for regulating iron).

No matter which way we look at it, inflammation is the common denominator.

So, how do we stop the inflammation that can lead to Restless Leg Syndrome?

Considering the overwhelming amount of research on the topic of systemic inflammation and a leaky gut, your gut is too important to be ignored.

However, a large majority of the medical community has yet to accept the role of the gut in the fight against RLS.

Dopamine-Agonist-300x169THE MEDICAL APPROACH TO TREATING RESTLESS LEG SYNDROME

Dopaminergic agents are often the first line of treatment in RLS. These drugs work to increase dopamine in the brain and include Requip, levodopa, and Neupro to name a few.

Known for their short-term effectiveness, they come with a long-term effects.

Augmentation is the most common side effect of dopaminergic drugs and occurs when the symptoms of RLS become more severe, happen earlier in the day, and spread to other parts of the body (i.e arms).

It’s estimated that over 80% of patients receiving levodopa for RLS develop augmentation.

With augmentation, the brain sees the extra dopamine (via medication) as a signal to decrease its natural production. The result? Patients become increasingly dependent on the drugs for relief.

Compulsive behavior is also a common side effect.

A study including 100 people with RLS (all were treated with dopaminergic agents) revealed well over 50% engaged in some type of compulsive behavior (ie. pathological gambling and compulsive eating habits).

After reading this, you may be wondering if there is a better way to treat RLS than the use of these dangerous medications.

THE LEAKY GUT – AUTOIMMUNE CONNECTIONleaky-gut-connection

If you’ve been keeping up with the latest information in natural health, you already know it’s nearly impossible to ignore a leaky gut as part of the cause and solution to autoimmune conditions like RLS.

Alessio Fasano, M.D. has been on the forefront of recent autoimmune disease research and published a paper titled “Leaky Gut and Autoimmune Diseases.”

His findings present the idea that in order for an autoimmune disease to develop, 3 conditions must all exist together:

1. A genetic predisposition to autoimmunity (i.e. BTBD9 gene in RLS)
2. An exposure to the environmental trigger (i.e. Iron Deficiency)
3. Increased intestinal permeability (a.k.a. Leaky Gut Syndrome)

For those with Restless Leg Syndrome, healing the gut means getting to the root cause so you can stop chasing your symptoms.

Healing a leaky gut is one factor that’s in our control and it can be done step-by-step with the right plan.

HOW TO TURN OFF AUTOIMMUNE DISEASE

Overcoming Restless Leg Syndrome requires a multifaceted approach to heal the gut and decrease inflammation – and that is exactly what we’re here to help you do.

Hippocrates, the famous Greek physician, stated “all disease begins in the gut,” and some 2,000 years later Fasano and many other leading experts agree.

Ancient and current wisdom both suggest that powerful healing must begin in the gut.

jordanJordan Reasoner is a health engineer and author. He was diagnosed with celiac disease in 2007 and almost gave up hope when a gluten-free diet didn’t work. Since then, he transformed his health using the SCD Diet and started SCDLifestyle.com to help others naturally heal stomach problems.

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2008 STUDY: Use of Low-Dose Hydrocortisone Lessen RLS Symptoms

CORT-Restless-Leg-Syndrome-Below is another study that supports the idea of inflammation being at the core of Restless Legs Syndrome.

It’s an older study I recently ran across that dispensed low-dose hydrocortisone to a small study group to see if their RLS symptoms would improve. The results of the study showed that symptoms were significantly lessened.

I’ve included an overview of the study below.

I’ve also included an excerpt from a SECOND study that demonstrates the powerful anti-inflammatory properties of hydrocortisone.

AND PLEASE NOTE, this is NOT an endorsement of hydrocortisone as a solution for RLS. It’s simply more evidence supporting the idea that INFLAMMATION is the PRIMARY cause of RLS. Which means, logically speaking, as you lessen your inflammation, your RLS will lessen.

This lessening of inflammation can be done in a natural way through diet, lifestyle, proper digestion etc. It doesn’t have to be a pharmaceutical anti-inflammatory.

STUDY ONEPuzzled male shrugging wearing lab coat

“Low-dose hydrocortisone in the evening modulates symptom severity in restless legs syndrome.” Hornyak M1, Rupp A, Riemann D, Feige B, Berger M, Voderholzer U. Neurology. 2008 Apr 29;70(18):1620-2. doi: 10.1212/01.wnl.0000310984.45538.89.

BACKGROUND

Circadian symptom manifestation in the evening and night is one of the main characteristics of restless legs syndrome (RLS). Although the inverse temporal course of corticosteroid rhythm and RLS symptom severity is obvious, this relationship has yet to be studied. We investigated the effect of late-evening application of exogenous cortisol (hydrocortisone) on sensory leg discomfort (SLD), one of the main complaints of patients with RLS.

METHODS

Ten untreated patients with idiopathic RLS participated in the study. Change of SLD was rated on a visual analogue scale during the 60 minutes resting period of the so-called Suggested Immobilization Test. Patients received either hydrocortisone 40 mg or placebo (saline) IV in random order in a double-blind crossover design, with 1 week between the experiments.

RESULTS

Severity of SLD was lower during hydrocortisone infusion than during placebo (p = 0.032). Though blind to the experimental condition, 5 of the 10 patients experienced improvement in symptoms during hydrocortisone administration, but no patient felt an amelioration during the placebo condition.

CONCLUSIONS

Our data indicate a probable physiologic relationship between evening and early night hour restless legs syndrome symptom increase and low cortisol level.

confused-doctorSTUDY TWO (excerpt)

“Low-dose hydrocortisone infusion attenuates the systemic inflammatory response syndrome.” The Phospholipase A2 Study Group. Briegel J1, Kellermann W, Forst H, Haller M, Bittl M, Hoffmann GE, Büchler M, Uhl W, Peter K. Clin Investig. 1994 Oct;72(10):782-7.

ABSTRACT

There is increasing evidence that the hypercortisolemia in inflammatory diseases suppresses the elaboration of *proinflammatory cytokines, thus protecting the host from its own defence reactions.

*A proinflammatory cytokine or more simply an inflammatory cytokine is a type of signaling molecule (a cytokine) that is excreted from immune cells like helper T cells (Th) and macrophages, and certain other cell types that promote inflammation from “Wikipedia Proinflammatory cytokine”

For helpful tips on how to lessen your RLS symptoms NATURALLY, please visit http://www.RLCure.com

 

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STUDY: MARIJUANA HELPS TO LESSEN RLS SYMPTOMS

cannabisIf you have followed this blog for awhile, or have visited my RLS website http://www.RLCure.com, you know that at the CORE of everything I present is that INFLAMMATION is the cause of RLS. In other words, eliminate the inflammation in your body and you will eliminate your RLS.

There are an ENDLESS number of ways in which inflammation can be introduced into your system, and there are unlimited ways in which it can be removed.

However, the REMOVAL requires a bit of effort and in most cases, a lot of sacrifice.

The articles below highlight how another anti-inflammatory agent has demonstrated success in lessening the effects of RLS.

Unfortunately for many of you, in this case the healing agent is MARIJUANA.

I want to make VERY clear that this post is not about promoting marijuana and endorsing it as a highly effective method to lessen your RLS symptoms. The idea of the post is to again emphasize that the KEY to your SUCCESS is to move towards an ANTI-INFLAMMATORY LIFESTYLE. That means that dietary, environmental, emotional, digestive changes etc. are required – anything that will move you away from continuing the inflammatory cycle that is at the heart of your RLS.

This is a total NON-ENDORSEMENT of smoking pot as a solution from yours truly, a man that has been in recovery from alcohol and drug addiction for over 30 years.

Smoking a DOOBIE may give you temporary relief, but unless you CHANGE your lifestyle, nothing permanent is going to take place. Your RLS will return.

Below are TWO articles. The FIRST one features a scientific study in which 5 out of 6 subjects had their RLS symptoms disappear thanks to the CHRONIC.

The SECOND article focuses on the tremendous anti-inflammatory properties of cannabis.

ARTICLE ONEMedical-Marijuana-Cures

MARIJUANA CAN STOP RESTLESS LEGS SYNDROME by Trey Reckling, The Fresh Toast

A small report published in the journal Sleep Medicine from the Bordeaux Hospital University Center in France is posing the question whether or not marijuana may help people with Restless Leg Syndrome to sleep better. The answer to that question is a crucial one for the 10-15 percent of people in the U.S. afflicted with the condition.

It’s easy to take sleep for granted when it’s working. When it’s not, it’s enough to drive you mad.

This is no secret for people who suffer from Restless Leg Syndrome (RLS). Even trying to classify the disorder is a challenge because it has crossover effect. It is sometimes classified as a sleep disorder because symptoms such as involuntary muscle twitching and jerking are initiated by inactivity or attempting to sleep. It can also be classified as a movement disorder because people affected sense an almost irresistible urge to move to reduce the uncomfortable sensation. But because the sensations originate in the brain, it could be argued that it is best identified as a neurological sensory disorder.

Regardless, to those who suffer from it, it means lack of sleep for starters. They can have a hard time both falling asleep and staying asleep. That lack of sleep impacts overall health, with negative impact on ability to concentrate, significant increase in daytime sleepiness and significantly lower productivity.

Sleep medicine expert, Dr. Imad Ghorayeb led the study.

mostpopularstrainsSome subjects reported taking seizure medications clonazepam and gabapentin with unsatisfactory results. All subjects reported prior efforts to alleviate their condition with prescription opiates and dopamine agonists for their RLS. They were ready for a new approach because nothing had worked for them or even made situations worse. Two subjects had experienced compulsive shopping and binge eating as a result of using dopamine agonists.

To be fair, there were a meager six subjects in the study. However, 5 of the 6 reported that smoking marijuana relieved their symptoms completely; one reported complete loss of RLS symptoms after using cannabidiol (CBD).

Researchers could not claim to understand why cannabis worked so well in the small group. They do suspect that it is related to the herb’s pain relieving properties and the effect could be enhanced by the sleepiness marijuana can induce.

While the researchers were not willing to fully endorse marijuana for those with restless leg syndrome, they admitted all subjects reported it was the most effective remedy they had tried so far.

Though small scale studies such as this one may not prove anything yet, they do lay important groundwork and interest for more in depth research.

You can read the full article here:
https://thefreshtoast.com/cannabis/marijuana-can-calm-restless-legs-so-you-can-sleep

ARTICLE TWOimages

CANNABIS FOR INFLAMMATION, WHY DOES IS WORK SO WELL? by Dana Smith, cannabis.net

Medical Marijuana For Inflammation and Swelling Works Wonders

Living a lifestyle that prevents inflammation is necessary in preventing chronic illnesses. This means eating a proper diet high in nutrients and inflammation-fighting foods, getting enough rest as well as regular exercise. Once you do have inflammation, it’s important to address it immediately otherwise it can lead to more serious conditions. Most people actually aren’t aware that inflammation affects almost every aspect of your health: arthritis, celiac disease, cancer, asthma, fibromyalgia, heart disease, diabetes, thyroid problems, and ADD just to name a few. Inflammation can be happening right now in your body, but you won’t know it because it takes years for it to be clinically significant, or until it manifests through symptoms of another disease.

restlesslegHow Does Cannabis Treat Inflammation?

Numerous studies have proven that cannabis is effective in treating inflammation as well as addressing the accompanying pain. This is because of the presence of its 2 major cannabinoids, THC and CBD.

Both THC and CBD are effective in reducing inflammation that is linked to several diseases. But another compound found in cannabis called the beta-carophyllene also affects the CB2 receptor. A 2008 study analyzing mice who had swollen paws and were given oral doses of beta-carophyllene showed a 70% decrease in inflammation. The mice without CB2 receptors didn’t see any improvement.

A study published by the US National Library of Medicine found that cannabinoids control the response of the immune system and works in suppressing inflammatory responses. The human endocannabinoid system has 2 receptors: CB1, which is located in the central nervous system, is responsible for psychoactive effects; and CB2, which is found in the tissues and is responsible for inhibiting inflammation.

Cannabis is also useful in keeping c-reactive protein levels down; high levels of this protein can lead to fatal heart disease. A study published in the Drug and Alcohol Dependence Journal revealed that people who smoked cannabis had lower levels of c-reactive protein than those who didn’t smoke. Another study showed that CBD was effective in blocking the progression of rheumatoid arthritis and was also beneficial in providing relief for pain caused by joint swelling. It’s already well known that cannabis is effective in treating chronic pain, which is a side effect of inflammation.

While we now know that THC and CBD work in treating and preventing inflammation, paperthey both work in the body in different ways. Both cannabinoids have demonstrated efficacy in decreasing both the release and production of pro-inflammatory cytokines and also works to decrease the activation of LPS-induced STAT 1 transcription factor, which contributes to some inflammatory processes. However scientists find that CBD is much more potent in addressing inflammation, and for this reason high CBD strains are recommended particularly for those who suffer from extreme inflammation. CBD actually supports the concentration of endogenous cannabinoids which gives the body the ability to self-heal and ward off disease.

You can read the full article here:
https://cannabis.net/blog/medical/cannabis-for-inflammation-why-does-is-work-so-well

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