Posts Tagged willis-ekbom disease

2008 STUDY: Use of Low-Dose Hydrocortisone Lessen RLS Symptoms

CORT-Restless-Leg-Syndrome-Below is another study that supports the idea of inflammation being at the core of Restless Legs Syndrome.

It’s an older study I recently ran across that dispensed low-dose hydrocortisone to a small study group to see if their RLS symptoms would improve. The results of the study showed that symptoms were significantly lessened.

I’ve included an overview of the study below.

I’ve also included an excerpt from a SECOND study that demonstrates the powerful anti-inflammatory properties of hydrocortisone.

AND PLEASE NOTE, this is NOT an endorsement of hydrocortisone as a solution for RLS. It’s simply more evidence supporting the idea that INFLAMMATION is the PRIMARY cause of RLS. Which means, logically speaking, as you lessen your inflammation, your RLS will lessen.

This lessening of inflammation can be done in a natural way through diet, lifestyle, proper digestion etc. It doesn’t have to be a pharmaceutical anti-inflammatory.

STUDY ONEPuzzled male shrugging wearing lab coat

“Low-dose hydrocortisone in the evening modulates symptom severity in restless legs syndrome.” Hornyak M1, Rupp A, Riemann D, Feige B, Berger M, Voderholzer U. Neurology. 2008 Apr 29;70(18):1620-2. doi: 10.1212/01.wnl.0000310984.45538.89.

BACKGROUND

Circadian symptom manifestation in the evening and night is one of the main characteristics of restless legs syndrome (RLS). Although the inverse temporal course of corticosteroid rhythm and RLS symptom severity is obvious, this relationship has yet to be studied. We investigated the effect of late-evening application of exogenous cortisol (hydrocortisone) on sensory leg discomfort (SLD), one of the main complaints of patients with RLS.

METHODS

Ten untreated patients with idiopathic RLS participated in the study. Change of SLD was rated on a visual analogue scale during the 60 minutes resting period of the so-called Suggested Immobilization Test. Patients received either hydrocortisone 40 mg or placebo (saline) IV in random order in a double-blind crossover design, with 1 week between the experiments.

RESULTS

Severity of SLD was lower during hydrocortisone infusion than during placebo (p = 0.032). Though blind to the experimental condition, 5 of the 10 patients experienced improvement in symptoms during hydrocortisone administration, but no patient felt an amelioration during the placebo condition.

CONCLUSIONS

Our data indicate a probable physiologic relationship between evening and early night hour restless legs syndrome symptom increase and low cortisol level.

confused-doctorSTUDY TWO (excerpt)

“Low-dose hydrocortisone infusion attenuates the systemic inflammatory response syndrome.” The Phospholipase A2 Study Group. Briegel J1, Kellermann W, Forst H, Haller M, Bittl M, Hoffmann GE, Büchler M, Uhl W, Peter K. Clin Investig. 1994 Oct;72(10):782-7.

ABSTRACT

There is increasing evidence that the hypercortisolemia in inflammatory diseases suppresses the elaboration of *proinflammatory cytokines, thus protecting the host from its own defence reactions.

*A proinflammatory cytokine or more simply an inflammatory cytokine is a type of signaling molecule (a cytokine) that is excreted from immune cells like helper T cells (Th) and macrophages, and certain other cell types that promote inflammation from “Wikipedia Proinflammatory cytokine”

For helpful tips on how to lessen your RLS symptoms NATURALLY, please visit http://www.RLCure.com

 

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STUDY: MARIJUANA HELPS TO LESSEN RLS SYMPTOMS

cannabisIf you have followed this blog for awhile, or have visited my RLS website http://www.RLCure.com, you know that at the CORE of everything I present is that INFLAMMATION is the cause of RLS. In other words, eliminate the inflammation in your body and you will eliminate your RLS.

There are an ENDLESS number of ways in which inflammation can be introduced into your system, and there are unlimited ways in which it can be removed.

However, the REMOVAL requires a bit of effort and in most cases, a lot of sacrifice.

The articles below highlight how another anti-inflammatory agent has demonstrated success in lessening the effects of RLS.

Unfortunately for many of you, in this case the healing agent is MARIJUANA.

I want to make VERY clear that this post is not about promoting marijuana and endorsing it as a highly effective method to lessen your RLS symptoms. The idea of the post is to again emphasize that the KEY to your SUCCESS is to move towards an ANTI-INFLAMMATORY LIFESTYLE. That means that dietary, environmental, emotional, digestive changes etc. are required – anything that will move you away from continuing the inflammatory cycle that is at the heart of your RLS.

This is a total NON-ENDORSEMENT of smoking pot as a solution from yours truly, a man that has been in recovery from alcohol and drug addiction for over 30 years.

Smoking a DOOBIE may give you temporary relief, but unless you CHANGE your lifestyle, nothing permanent is going to take place. Your RLS will return.

Below are TWO articles. The FIRST one features a scientific study in which 5 out of 6 subjects had their RLS symptoms disappear thanks to the CHRONIC.

The SECOND article focuses on the tremendous anti-inflammatory properties of cannabis.

ARTICLE ONEMedical-Marijuana-Cures

MARIJUANA CAN STOP RESTLESS LEGS SYNDROME by Trey Reckling, The Fresh Toast

A small report published in the journal Sleep Medicine from the Bordeaux Hospital University Center in France is posing the question whether or not marijuana may help people with Restless Leg Syndrome to sleep better. The answer to that question is a crucial one for the 10-15 percent of people in the U.S. afflicted with the condition.

It’s easy to take sleep for granted when it’s working. When it’s not, it’s enough to drive you mad.

This is no secret for people who suffer from Restless Leg Syndrome (RLS). Even trying to classify the disorder is a challenge because it has crossover effect. It is sometimes classified as a sleep disorder because symptoms such as involuntary muscle twitching and jerking are initiated by inactivity or attempting to sleep. It can also be classified as a movement disorder because people affected sense an almost irresistible urge to move to reduce the uncomfortable sensation. But because the sensations originate in the brain, it could be argued that it is best identified as a neurological sensory disorder.

Regardless, to those who suffer from it, it means lack of sleep for starters. They can have a hard time both falling asleep and staying asleep. That lack of sleep impacts overall health, with negative impact on ability to concentrate, significant increase in daytime sleepiness and significantly lower productivity.

Sleep medicine expert, Dr. Imad Ghorayeb led the study.

mostpopularstrainsSome subjects reported taking seizure medications clonazepam and gabapentin with unsatisfactory results. All subjects reported prior efforts to alleviate their condition with prescription opiates and dopamine agonists for their RLS. They were ready for a new approach because nothing had worked for them or even made situations worse. Two subjects had experienced compulsive shopping and binge eating as a result of using dopamine agonists.

To be fair, there were a meager six subjects in the study. However, 5 of the 6 reported that smoking marijuana relieved their symptoms completely; one reported complete loss of RLS symptoms after using cannabidiol (CBD).

Researchers could not claim to understand why cannabis worked so well in the small group. They do suspect that it is related to the herb’s pain relieving properties and the effect could be enhanced by the sleepiness marijuana can induce.

While the researchers were not willing to fully endorse marijuana for those with restless leg syndrome, they admitted all subjects reported it was the most effective remedy they had tried so far.

Though small scale studies such as this one may not prove anything yet, they do lay important groundwork and interest for more in depth research.

You can read the full article here:
https://thefreshtoast.com/cannabis/marijuana-can-calm-restless-legs-so-you-can-sleep

ARTICLE TWOimages

CANNABIS FOR INFLAMMATION, WHY DOES IS WORK SO WELL? by Dana Smith, cannabis.net

Medical Marijuana For Inflammation and Swelling Works Wonders

Living a lifestyle that prevents inflammation is necessary in preventing chronic illnesses. This means eating a proper diet high in nutrients and inflammation-fighting foods, getting enough rest as well as regular exercise. Once you do have inflammation, it’s important to address it immediately otherwise it can lead to more serious conditions. Most people actually aren’t aware that inflammation affects almost every aspect of your health: arthritis, celiac disease, cancer, asthma, fibromyalgia, heart disease, diabetes, thyroid problems, and ADD just to name a few. Inflammation can be happening right now in your body, but you won’t know it because it takes years for it to be clinically significant, or until it manifests through symptoms of another disease.

restlesslegHow Does Cannabis Treat Inflammation?

Numerous studies have proven that cannabis is effective in treating inflammation as well as addressing the accompanying pain. This is because of the presence of its 2 major cannabinoids, THC and CBD.

Both THC and CBD are effective in reducing inflammation that is linked to several diseases. But another compound found in cannabis called the beta-carophyllene also affects the CB2 receptor. A 2008 study analyzing mice who had swollen paws and were given oral doses of beta-carophyllene showed a 70% decrease in inflammation. The mice without CB2 receptors didn’t see any improvement.

A study published by the US National Library of Medicine found that cannabinoids control the response of the immune system and works in suppressing inflammatory responses. The human endocannabinoid system has 2 receptors: CB1, which is located in the central nervous system, is responsible for psychoactive effects; and CB2, which is found in the tissues and is responsible for inhibiting inflammation.

Cannabis is also useful in keeping c-reactive protein levels down; high levels of this protein can lead to fatal heart disease. A study published in the Drug and Alcohol Dependence Journal revealed that people who smoked cannabis had lower levels of c-reactive protein than those who didn’t smoke. Another study showed that CBD was effective in blocking the progression of rheumatoid arthritis and was also beneficial in providing relief for pain caused by joint swelling. It’s already well known that cannabis is effective in treating chronic pain, which is a side effect of inflammation.

While we now know that THC and CBD work in treating and preventing inflammation, paperthey both work in the body in different ways. Both cannabinoids have demonstrated efficacy in decreasing both the release and production of pro-inflammatory cytokines and also works to decrease the activation of LPS-induced STAT 1 transcription factor, which contributes to some inflammatory processes. However scientists find that CBD is much more potent in addressing inflammation, and for this reason high CBD strains are recommended particularly for those who suffer from extreme inflammation. CBD actually supports the concentration of endogenous cannabinoids which gives the body the ability to self-heal and ward off disease.

You can read the full article here:
https://cannabis.net/blog/medical/cannabis-for-inflammation-why-does-is-work-so-well

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Participants sought for restless legs study

Individuals with restless or unpleasant feelings in their legs at night or at rest, that are relieved by movement are needed. We are studying the possible benefits of yoga versus an educational film program for reducing symptoms of restless legs syndrome. Participants will attend up to two classes per week in Morgantown for 12 weeks. The study also involves two visits to WVU to complete questionnaires. Compensation is $150 upon completion of this research study. IRB approval on file (1505699758)

For additional information, contact:

  • WVU School of Public Health, Department of Epidemiology
  • Caitlin Montgomery, MPH
  • 304.293.2082, cmontgo2@mix.wvu.edu

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“The Common Causes of Restless Legs Syndrome” by Dr. Aaron Ernst

AskDrErnstRestless legs syndrome is a seemingly unique condition and the cause is often difficult to pinpoint.

Few things are more frustrating than lying in bed at night, exhausted, but not being able to fall asleep because of an uncontrollable urge to move your legs. It seems so strange, doesn’t it? This phenomenon, known as restless legs syndrome (RLS), affects between 4% and 29% of adults in Western populations, and is a major contributor to sleep loss.

Pinpointing the cause of RLS has been an active research topic for years, but the condition is still not fully understood. The symptoms have been convincingly linked to impaired dopamine function in the brain, but the cause of this dysfunction is still being explored. Here are my top causes:

1. Systemic Inflammation & Immune Dysregulation (Subluxation)

One review paper published in 2012 investigated health conditions that were reported to Acute pain in a woman hand. Isolation on a white backgroundcause or exacerbate RLS symptoms, and found that 95% of the health conditions that are associated with RLS have an inflammation or immune component. As further evidence, an elevated blood level of C-reactive protein (a marker of systemic inflammation) has been associated with increased RLS severity.

Researchers have proposed three potential mechanisms to explain the association between RLS and inflammatory or autoimmune states: direct autoimmune attack on the nervous system; genetic factors that could predispose an individual to RLS and be triggered by inflammation or autoimmunity; and vitamin D deficiency caused by inflammation, which I’ll talk more about below.

What to do: If your RLS is a symptom of underlying systemic inflammation or immune dysregulation, the goal should be to find and treat the root cause & reduce the stressors to the central nerve system and spine. Often we see the issue target to L5/S1 regions.

2. Small Intestinal Bacterial Overgrowth (SIBO) and IBS

A recent study found that 69% of RLS patients also had SIBO, compared with only 28% of control subjects. They also found that 28% of RLS patients had IBS, compared to only 4% of controls. And according to the 2012 review I mentioned above 32% of the health conditions associated with RLS are also associated with SIBO. As I’ve mentioned many times in the past neurological interference & gut infections are often the culprit—even if you don’t have noticeable symptoms—its worth getting your gut tested.

What to do: If you have RLS and suspect you may have SIBO or a gut issue its best to get tested to find our what is going on in there. Generally speaking, the intestines need to be flushed or cleansed then re-inoculated with healthy living strains of bacteria. Your typical probiotic won’t be able to do that. Overall the best approach is to follow a ketosis diet with bone broth until symptoms subside (and your SIBO tests are normal), and then gradually re-introduce fermented foods and probiotics.

3. Vitamin D Deficiency

One of the most-researched theories about the cause of restless legs syndrome is impaired dopamine signaling, which has led to the conventional treatment of RLS by dopamine agonists (i.e. chemicals that can bind to and activate dopamine receptors). Unfortunately, these treatments can become less effective over time, and can even result in a worsening of symptoms.

vitaminThis is where vitamin D comes into play. The role of vitamin D in dopamine signaling is only beginning to be investigated, but some evidence indicates that vitamin D could play an important role by increasing levels of dopamine and its metabolites in the brain, as well as protecting dopamine-associated neurons from toxins.

RLS has been associated with vitamin D deficiency in several studies, and disease severity has been inversely correlated with vitamin D levels. One study has also found that vitamin D supplementation improved the severity of RLS symptoms.

What to do: If you have RLS, one of the easiest first steps you can take is to get your vitamin D levels tested. A good range to shoot for is typically between 40-60 ng/mL. If you have an autoimmune disease or another chronic health condition, optimal levels are between 60-80 ng/mL. One way to supplement vitamin D is through taking it directly. And of course, you should get regular sun exposure.

We’re still learning more and more about this syndrome, and hopefully we’ll come to some truly concrete answers soon enough. But as is so often the case, watching your nutrition and lifestyle goes a really long way in taking care of these sorts of issues.

This information originally appeared on the “Ask Dr. Ernst” website.
https://askdrernst.com/common-causes-restless-leg-syndrome

Dr. Aaron Ernst completed his undergraduate education in pre-medicine/biology at Messiah University in Grantham, PA. As a first generation holistic practitioner, he began his career with a Doctorate in Chiropractic from Logan College of Chiropractic in Chesterfield, MO.  While in Missouri, Dr. Aaron began helping patients rebuild their health in a Maximized Living Health center, which was the largest wellness clinic in Missouri. His experience has led him to spend countless hours studying and researching to create procedures and protocols to rebuild health naturally. Dr. Aaron has traveled all over North America, Europe and Africa teaching the principles of Maximized Living and educating all generations on gaining victory over disease naturally.

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Another Scientific Link Between Restless Legs Syndrome and Inflammation

chronic-illness-46-638Below is an excerpt from an article titled “Inflammation and Pain Management with Magnesium” by Dr. Mark Sircus, Ac., OMD, DM (P), December 8, 2009

“According to the National Sleep Foundation approximately 70 million people in the United States are affected with sleeping disorders. Approximately 12 million Americans have Restless Legs Syndrome, a sleep and movement disorder characterized by unpleasant (tingling, crawling, creeping and/or pulling) feelings in the legs, which cause an urge to move in order to relieve the symptoms.  

‘People with poor quality sleep or sleep deprivation exhibit increased levels of interleukin-6 (IL6), the chemical that causes inflammation throughout the body’ (Redwine et al. 2000).”

The above excerpt is a short but effective overview of the way that Restless Legs Syndrome feeds off itself; ever increasing the stranglehold it has over each individual.

The original RLS-causing inflammation in your body could have been created because of a number of issues. It’s  likely that diet is involved, but there are many other possible contributors such as lifestyle, environment & toxins, alcohol consumption, stress, pregnancy, aging etc.

Once the inflammation inside you reaches a level that causes your legs to start tingling … a whole new (ugly) cycle begins!

The lack of sleep you begin to experience because of your wonky legs AS WELL AS the stress of the increasing frustration BOTH raise the existing inflammation level inside of you.

And, of course, as time goes on, it just gets worse. It’s an ugly, ugly debilitating cycle.

Your sleep gets worse, the inflammation increases. Your stress gets higher, the inflammation increases. Your anger deepens, the inflammation increases.

Yes, all the while, the RLS-causing inflammation inside of you increases, raising your inflammation and RLS to new levels.

THE SOLUTION:

Healing RLS requires a multi-pronged attack. You can’t just take a pill and wish it all away.  Taking a prescribed medication expecting it to rid your RLS is like closing the door to a room that is on fire expecting the fire to die out.

The inflammation inside of you is going to continue to increase and manifest in other ways. (I explain how RLS is actually a warning signal from your body, on my website http://www.rlcure.com).

To rid yourself of RLS you need to:

1. Put a cork in where the inflammation is flowing into your life.

This means, first off, change your diet! Get the sugar, trans & saturated fats, gluten, alcinflammatoryfoodsohol, refined carbohydrates and MSG out of your life, as best you can. Give your body a chance to heal. It doesn’t have to be forever, just give it some breathing room to heal itself.

It also means that you need to learn to calm down.

Meditation, relaxation exercises and yoga have all been clinically proven to lower inflammation levels.

I still believe that no one is beyond help when it comes to RLS and inflammation. Regardless of how hopeless you think your situation is, if you’re willing to make necessary sacrifices and put in the work, you can be healed.

For some helpful tips on natural ways to put out the fire that’s raging inside your body, please visit my website http://www.rlcure.com

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Restless Legs Symptoms Lessened with D-ribose

ATP_moleculeWhenever I run across something that has helped lessen a person’s RLS symptoms, whether it be a personal story or through a study, I know with 100% certainty that if I do a search on whatever it is they took to lessen their symptoms, that healing ingredient will have proven anti-inflammatory properties.

Such is the case with D-Ribose.

“D-Ribose is a naturally occurring five-carbon monosaccharide that is found in all living cells, and has anti-inflammatory effects in renal ischemia/reperfusion injury” (Ueki et al. 2013).

“D-ribose has anti-inflammatory activities and protects against damage mediated via inflammation.” from “D-ribose for energizing brain, autism and ADD/ADHD” by Dr. Anil Minocha, Board certified in Internal Medicine, Gastroenterology and Nutrition

I ran across a RLS study that was done in 2008 that showed great promise in a father and son with Restless Legs that were both given D-ribose.

I am going to post the results of the study followed by some basic information about what D-ribose is.

I realize in the great theater of science that this study doesn’t prove anything. However, to someone still suffering from RLS that is trying to find the slightest glimmer of hope, this is yet more evidence shining its light on the DIRECT LINK between RLS and INFLAMMATION.

STUDY: “D-ribose benefits restless legs syndrome.” (Shecterle et al. 2008).400x250xheart.jpg.pagespeed.ic.8Q2L_vwUPa

We report on two affected male individuals, a father and son, ages 71 and 47, from a family in which three generations carry the diagnosis. To evaluate any potential benefit of D-ribose in this condition, each individual orally consumed 5-g doses of D-ribose daily at different trial stages. Each stage lasted 3 weeks with a 2-week washout period between stages.

The initial stage involved a single 5 gm dose of D-ribose consumed at breakfast. Throughout the second stage, D-ribose was taken at breakfast and lunch. In the third stage, D-ribose was taken at all meals, breakfast, lunch, and dinner. Diaries by the subjects pertaining to their documentation and severity of restless legs syndrome symptoms was compiled. During the initial stage both men reported a general feeling of more energy and less fatigue, most notably after exercise, without any significant changes in their symptoms.

With the increase in the daily dose of D-ribose, in the second stage, their leg twitching and the feeling to move during the day was reduced for 1 subject, and rarely present in the other. Both still experienced the unpleasant sensations during the night.

However, during the final stage, a further increase in the daily dose of D-ribose eliminated their daily symptoms and the symptoms at night were of a lesser degree and had a later occurrence. Both men reported that D-ribose did not totally eliminate their discomfort, but the severity and onset of symptoms affecting their quality of life was substantially improved with D-ribose without any adverse reactions.

Jacob-Teitalbaum-Photo“D-Ribose–The Natural Body Energizer” from “Fatigued to Fantastic!” by Jacob Teitelbaum, M.D. (2007)

In looking at energy production, it helps to look at the “energy molecules” such as ATP, NADH, and FADH. These represent the energy currency in your body, and are like the paper that money is printed on. You can have all the fuel you want, but if it cannot be converted to these molecules, it is useless!

For years, I talked about the importance of B vitamins, which are a key component of these molecules. These helped to a degree, but it was clear that a key component was missing. In looking at the biochemistry of these energy molecules, they are also made of 2 other key components-adenine and ribose. Adenine is plentiful in the body and supplementing with adenine did not help CFS. We then turned our attention to Ribose. Ribose is made in your body in a slow, laborious process and cannot be found in food. We knew that CFS/FMS causes your body to dump other key energy molecules like acetyl-l-carnitine. We then found that the body did the same with Ribose, making it hard to get your furnaces working again even after the other problems were treated.

This was like one of those “Eureka!” moments where things came together. Not having Ribose would be like trying to build a fire without kindling—nothing would happen. We wondered if giving Ribose to people with CFS would jump-start their energy furnaces. The answer was a resounding yes!

Our recently published study (see the study abstract in Appendix B) showed an average 44.7% increase in energy after only 3 weeks (improvement began at 12 days) and an average overall improvement in quality of life of 30%. Two thirds of the CFS/FMS patients felt they had improved.19 Usually a 10% improvement for a single nutrient is considered excellent. A 44.7% increase left us amazed, and I am now recommending Ribose for all of my CFS/FMS patients, for athletes, and any one with pain, fatigue or heart problems. Ribose recently became available (over the counter) to physicians, and is one of the few natural products actually starting with physicians and then moving out into health food stores.

It is critical to use the proper dose for the first 3 weeks, which is 5 grams (5000 mg) three times a day. It can then be dropped to twice a day. I recommend the Corvalen form of ribose as it is the least expensive and highest quality and is packaged with a 5 gm dosing scoop in it. One 280 gm container will be enough to tell you if it will work. Corvalen M (which has ribose plus magnesium and malic acid) is also available, but if you are also taking the Energy Revitalization System vitamin powder (see chapter X), you are already getting the magnesium and malic acid, and the regular Corvalen is a better deal financially. Bioenergy, which makes Corvalen, also conducts almost all of the research on Ribose, knows the most about it, and has outstanding customer service in case you have any questions. Because of its importance, it’s worth looking at energy production and Ribose in greater detail. Having had the chance to explore the research and speak with a number of the researchers, below is what I’ve learned from them.

D-Ribose Accelerates Energy RecoveryRiboseChart2

D-Ribose (which is what I am referring to when I say ribose) is a simple, five-carbon sugar (known as a pentose by biochemists) that is found naturally in our bodies. But ribose is not like any other sugar. Sugars we are all familiar with, such as table sugar (sucrose), corn sugar (glucose), milk sugar (lactose), honey (predominantly fructose), and others are used by the body as fuel. These sugars are consumed and, with the help of the oxygen we breathe, are “burned” by the body to recycle energy. Because they are used excessively, they can also be toxic, as we’ve discussed earlier. Ribose, on the other hand, is special. When we consume ribose, the body recognizes that it is different from other sugars and preserves it for the vital work of actually making the energy molecule that powers our hearts, muscles, brains, and every other tissue in the body.

A key molecule, called adenosine triphosphate (or ATP for short), is known as the energy currency of the cell because the amount of ATP we have in our tissues determines whether we will be fatigued, or will have the energy we need to live vital, active lives. Ribose provides the key building block of ATP, and the presence of ribose in the cell stimulates the metabolic pathway our bodies use to actually make this vital compound. If the cell does not have enough ribose, it cannot make ATP. So, when cells and tissues become energy starved, the availability of ribose is critical to energy recovery.

Normal, healthy heart and muscle tissue has the capacity to make all the ribose it needs. When normal tissue is stressed by overexertion, several days of rest will usually allow it to fully recover. The muscle may be sore during recovery, as we frequently see for the three or four days after a hard day of yard work or after a weekend pick up football game, but eventually energy levels will be restored and the soreness will disappear. But when the muscle is chronically stressed by disease or conditions that affect tissue energy metabolism, the cells and tissues simply cannot make enough ribose quickly enough to recover. Hearts and muscles just don’t have the metabolic machinery they need to make ribose very efficiently. The result is chronic, persistent pain, stiffness, soreness, and overwhelming fatigue that may never go away.
The Link between Ribose, Energy, and Fatigue

Clinical and scientific research has repeatedly shown that giving ribose to energy deficient hearts and muscles stimulates energy recovery. One important study involved healthy athletes participating in high-intensity, endurance exercise over the course of one week. After exercise the energy level in the athlete’s muscle was reduced by almost 30%. Giving 10-grams of ribose per day for three days following exercise restored muscle energy levels to normal, while treatment with placebo provided virtually no effect.20 This study clearly showed that ribose stimulated the energy recovery pathways in the body, helping the muscle rebuild its energy supply quickly and completely. Even after three days of rest, muscle that was not treated with ribose remained energy starved and fatigued.

Two very interesting studies in animals showed how dramatic the effect of ribose could be on energy recovery in fatigued muscle. These studies were conducted by Dr. Ron Terjung, one of the top muscle physiologists in the U.S. In their research, Dr. Terjung and his co-investigators found that ribose administration in fatigued muscle increased the rate of energy recovery by 340% to 430%, depending on which type of muscle was tested.21 He also found that even very small amounts of ribose had the effect of helping the muscle cell preserve energy, a process known as energy salvage, and the higher the ribose dose, the more dramatic the effect on energy preservation.22 Although this groundbreaking research was done in animals it was instrumental in defining the biochemistry and physiology associated with the use of ribose in overcoming heart and muscle fatigue. But most of us with CFS and FMS are neither top athletes nor animals, so the question remains, “How will ribose affect me?”

D-Ribose-ArticleResearch in Ribose and CFS/FMS began with a case study that was published in the prestigious journal Pharmacotherapy in 2004.23 This case study told the story of a veterinary surgeon diagnosed with fibromyalgia. For months, this dedicated doctor found herself becoming more and more fatigued, with pain becoming so profound she was finally unable to stand during surgery. As a result, she was forced to all but give up the practice she loved.

Upon hearing that a clinical study on ribose in congestive heart failure was underway in the university where she worked, she asked if she could try the ribose to see if it might help her overcome the mind-numbing fatigue she experienced from her disease. After three weeks of ribose therapy she was back in the operating room, practicing normally with no muscle pain or stiffness, and without the fatigue that had kept her bedridden for many months.

Being a doctor, she was skeptical, not believing that a simple sugar could have such a dramatic effect on her condition. Within two weeks of stopping the ribose therapy, however, she was out of the operating room and back in bed. So, to again test the theory, she began ribose therapy a second time. The result was similar to her first experience, and she was back doing surgery in days. After yet a third round of stopping (with the return of symptoms) and starting (with the reduction of symptoms) the ribose therapy, she was convinced, and has been on ribose therapy since that time.

I found this report intriguing and decided to design the larger study in patients with fibromyalgia or chronic fatigue syndrome which I began to discuss earlier. Along with two research collaborators, I recently published a scientific paper describing the results of this research. The study we designed was intended to determine whether or not ribose would be effective in relieving the overwhelming fatigue, pain, soreness, and stiffness suffered by patients having this debilitating condition. Our study included 41 patients with a diagnosis of fibromyalgia or chronic fatigue syndrome who were given ribose at a dose of 5-grams three times per day for an average of three weeks. We found the ribose treatment led to significant improvement in energy levels, sleep patterns, mental clarity, pain intensity, and well being. Of the patients participating in the study, 65.7 % experienced significant improvement while on ribose, with an average increase in energy of 44.7% and overall well being of 30%- remarkable results from a single nutrient! 19 The only significant side effects were that 2 people felt too energized and hyper/anxious on the ribose. This is simply dealt with by lowering the dose and/or taking it with food.

To further validate these findings, we are currently conducting a much larger placebo controlled study, and hope to have theimages results published in the coming year. Interestingly, one of our study patients had an abnormal heart rhythm called atrial fibrillation. Ribose is outstanding in the treatment of heart disease as well, because it restores energy production in the heart muscle. Because of this, it was not surprising that this man’s atrial fibrillation also went away on the ribose and he was able to stop his heart medications as well! Because of its importance and the research showing marked heart muscle dysfunction (because of low energy) in CFS, let’s look at Ribose and the heart in more detail.

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“Is Vitamin D Deficiency to Blame for Your Restless Legs?” by Dr. Robert Rosenberg, The Sleep Disorders Centers of Prescott Valley and Flagstaff

vitamindEditor’s Note: Please understand that although I publish any  hopeful information I can when it comes to natural remedies for RLS, I still stand firm in the belief that INFLAMMATION is the cause of RLS. So, a Vitamin D deficiency may be the cause (or may contribute) for some people, while others it may be a Vitamin B12 deficiency, for other an Iron deficiency, for others a Magnesium deficiency … and in most cases, just bad eating habits and stress.

They have yet to identify inflammation as being the real problem, and the ways that the inflammation is created, as being secondary. I don’t mean secondary as being ” less important,” what I mean is that you first have to identify the problem, admit that it exists, before the REAL healing can start. Once you have identified the problem, that your RLS is a symptom of the chronic inflammation in your body, then you can try and figure out how it got there, and how you can get rid of it.

As the saying goes “identifying the problem is HALF of the solution.”

However, instead of articles and studies that identify the real problem, what continually appears in the press are articles like the one below that attempts to identify the “ONE THING” that will set your legs free. They look for something we can BLAME it all on.

I totally agree with what Dr. Sircus stated in my previous post “no single medicine or nutritional agent has the power to both treat and prevent chronic inflammatory conditions.”

In other words, yes, a Vitamin D deficiency is inflammatory, and should be avoided at all costs. However, taking Vitamin D is not going to “cure” you if you are still leading an inflammatory lifestyle (including stress) or are consuming inflammatory foods.

Here is the article by Dr. Rosenburg:vitamindmonth2

“Within the past few years there have been several studies linking vitamin D to various sleep disorders. This connection is not surprising since vitamin D is involved in the regulation of calcium, phosphorous, and bone growth, as well as muscle function, immune regulation, and brain function.

There have also been studies linking vitamin D deficiency to sleepiness and enlarged tonsils in children, resulting in pediatric sleep apnea. Among the newer studies released, one of the most interesting studies is a new study, published August 2014 in the journal Sleep Breath titled The Effect of Vitamin D Supplements on the Severity of Restless Legs Syndrome, which links vitamin D deficiency to restless legs syndrome (RLS).

The study followed 12 subjects, all of whom were diagnosed with both primary RLS (meaning there was no other obvious cause) and vitamin D deficiency. All 12 patients were treated with vitamin D. After their levels returned to normal, they were reassessed. The severity of their RLS also significantly improved after treatment, causing the study authors to conclude that vitamin D deficiency may be associated with RLS.

This news comes on the heels of several other studies that have shown low levels of vitamin D in people with RLS.

vitd1There are many places in which you can find vitamin D. One source is our skin, which can produce vitamin D upon exposure to sunlight. Vitamin D can also be found in certain foods including:

Milk
Cheese
Eggs
Oily fish (salmon, cod, and mackerel)

Low levels of vitamin D can be caused by dark skin pigmentation, limited sunlight exposure, pregnancy, abnormal intestinal absorption, and some medications.

As a result of these studies — and several other studies correlating vitamin D to restless legs syndrome, sleep apnea, excessive sleepiness, and nighttime muscle cramps – I intend to start checking my patient’s vitamin D levels more often. I am only sorry that I was not aware of this relationship before. Just a decade ago, most of us in sleep medicine would never have imagined that the same vitamin deficiency that can cause rickets and osteoporosis could be
involved in sleep disorders. Modern medicine never fails to amaze or humble me.”

7aa229a83d4c9bbb98f4434bf37fce83Dr. Robert Rosenberg first started practicing medicine in Chicago as an associate professor at the Chicago College of Osteopathic Medicine where he taught students, interns, and residents and attended to patients. In 1982, he moved to Arizona and opened a private practice focusing on internal medicine, pulmonary medicine and sleep medicine. He continued to teach in Arizona and California. In recent years, he’s limited his practice to sleep medicine, and he’s also started writing, blogging, and lecturing on sleep. His expertise as a sleep physician has been featured in various publications, including Newsweek and Oprah Magazine, and he also serves as a forensic sleep medical consultant for legal cases. Dr. Rosenberg sees patients at his private practices, the Sleep Disorders Centers of Prescott Valley and Flagstaff, both in northern Arizona. His first book is titled “Sleep Soundly Every Night, Feel Fantastic Every Day,”  

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