The Truth About Restless Legs Syndrome (RLS)

This RLS Blog contains a LOT of information about Restless Legs Syndrome, covering a wide spectrum of different areas and aspects.

Because of that, a casual passerby at 4am that’s just trying to find a solution for their wonky legs may be overwhelmed or frustrated as they have to dig through information on epigenetics, glutamate, histamine etc. in order to find out what this “CURE” is all about.

For that reason I have created this post which I will LOCK into the first position on the blog so that this overview of “An Absolute Cure for RLS” will always be visible to newcomers.


Throughout our early history the majority of the world’s population considered the earth to be flat. That was a normal way to think.

If you were to shout out that the world was ROUND back then, you would have probably been pelted with rotten vegetables.

You would have been called a NUT … a person DESPERATE for attention.

And then things changed.

In the early 16th century, Ferdinand Magellan proved to the Western World, that without a doubt, the world was in fact ROUND.

A new awareness was created.

But there were MANY before him that had the same knowledge. Ferdinand Magellan was simply part of a lineage of belief.

Despite the fact that most of the 300 million inhabitants of the planet in the early 1600’s believed the world to be flat, and but a small handful of astronomer-types believed it to be round, the truth was never altered. Not for a second. It was ALWAYS waiting there to be discovered.

A belief never has nor ever will alter the truth. The number of people supporting the belief does not matter.

ImageSo, What’s My Point?

Please understand, I’m not saying that I’m ANYTHING like Ferdinand Magellan. He had more courage in his baby toe than I have in my entire body.

But, despite my foibles, I have also stumbled upon a truth. And despite what anyone says, regardless of their intelligence, their degrees, their stature or whatever following they may have, there is NOTHING on earth that is going to change this simple truth that I have stumbled upon.

The simple truth is this basic formula.


Regardless of what your reaction may be to me, my views, or natural remedies in general … this truth that I am presenting to you is NEVER going to change.



There is NO case of RLS that is beyond repair.

But please note … it is a PROCESS of RECOVERY. There is no magic pill.

You are exchanging your inflammatory diet and lifestyle (removing whatever it is in your life that is causing the inflammation in your body) for an anti-inflammatory diet and lifestyle.

As you can imagine, many sacrifices will need to be made. Some will be drastic. For starters you need to cut down on inflammatory items such as sugar, alcohol, refined flours, caffeine and dairy.

It may seem impossible, but if you move in this healthy direction, I can assure you that the sacrifices you make will pay off.

ImageI had horrible RLS for 23 years. I am now living a life I could have only dreamed of a few years ago. Words cannot express how grateful and relieved I am to have normal healthy legs and regular sleeping habits.

Something I learned from my own experience is that the MORE effort you put into your recovery, the FASTER you will heal.

If the only change you’re willing to make is to buy some magnesium or cut down on your sugar intake, then your recovery will be SLOW.

If you follow the advice given on this website, and go at your recovery with EVERYTHING you have … you will be rewarded for your efforts!


If a fire breaks out in your kitchen, the first thing you need to do in order to save your house is to put out the fire!

It’s pretty basic logic. You can worry about the smoke damage, your melted toaster, the ruined curtains and whether or not your insurance covers the damage … after the fact.

But until you put that fire out, nothing else matters.

You must take the same approach when taking on your RLS. You must first PUT OUT the fire that is causing your restless legs.

Nothing else matters. You can switch medications all you want … but until you shift your WILL, and make a CONSCIOUS decision to stop eating and drinking the inflamatory substances that are ADDING TO YOUR INFLAMMATION … NOTHING is going to change!


Look at each supplement below as a different firefighter with a firehose. The best way you can attack the inflammation is from ALL angles with as many firefighters as you can round up. This will speed up the healing process immeasurably.

Again, it’s crucial … absolutely essential that you begin to watch your diet. You need to at least pull back a bit from your regular intake of the most common RLS triggers (caffeine, gluten, aspartame, sugar, dairy, salt, MSG, red meat and alcohol).

Taking the supplements while you continue to consume a diet FULL of RLS triggers, is like spraying TWO hoses on the fire – one hose pouring WATER on the fire and the other hose pouring GASOLINE on the fire.

Little progress will be made, if any.


Supplements are often expensive. With that in mind I have created a “BASIC GROUP” of supplements that should be affordable for most people.

For those with a wider budget, I have a list of additional supplements that you can pick and choose from.

Keep in mind that the supplements listed below are addressing THREE main areas.

1. It is certain that you have chronic inflammation. This will be lessened.

2. It is very likely that you have higher than normal histamine levels, which contributes to a racing mind and sleepless nights. This will be lowered.

3. It is very likely that you have higher than normal glutamate levels, which also contributes to a racing mind and sleepless nights. This will be lowered.

Calcium + Magnesium “CalMag” (anti-inflammatory, natural antihistamine, lowers glutamate level)

Magnesium (Mg) is a co-factor in several hundred enzymatic reactions in the human body. Magnesium reduces histamine release. Magnesium plays a direct role in lowering common inflammatory markers.  

Carrot Juice (anti-inflammatory)

Carrots are perhaps best known for their rich supply of the antioxidant nutrient that was actually named for them: beta-carotene. However, these delicious root vegetables are the source not only of beta-carotene, but also of a wide variety of antioxidants and other health-supporting nutrients.

ImageCurcumin (anti-inflammatory, natural antihistamine)

A component of the popular Indian curry spice turmeric, Curcumin is considered a potent non-steroidal, anti-inflammatory. Curcumin has been shown to be as effective as cortisone and phenylbutazone in decreasing inflammation. It also works in several ways to decrease inflammation by reducing prostaglandin activity.

Grape Seed Extract (anti-inflammatory, natural antihistamine, lowers glutamate level)

Grape Seed Extract is one of the most potent antioxidants known; over 50 times more potent than Vitamin E or C. It acts as a natural antihistamine and anti-inflammatory. The main active component is its high content of proanthocyanidin (OPC or PCO). Proanthocyanidin is found in red, white, and purple grapes, blueberries, cherries and plums.

Iron (anti-inflammatory)

Iron is an essential mineral whose main function is to help carry oxygen from the lungs to the muscles and other organs. Iron deficiency is more common than many think. It is estimated that only 65-70% of all Americans meet their daily recommended intake.

ImageL-Theanine (lowers glutamate level)

L-Theanine is thought to be the key to tea’s subtle but calming effects despite the caffeine content in tea. L-Theanine is thought to counter the stimulating effects of caffeine by increasing the production of alpha brain waves. Alpha waves are associated with a state of deep relaxation while being mentally alert.

Omega 3 (anti-inflammatory, natural antihistamine)

Extensive research indicates that omega-3 fats reduce inflammation, helping to prevent inflammatory diseases like heart disease and arthritis. The omega-3 fatty acids can also be natural antihistamines that are useful to combat allergies as they reduce the inflammatory reaction associated with allergies.

Valerian Tea (anti-inflammatory, natural antihistamine, lowers glutamate level)

Valerian works exceedingly well for anxiety, insomnia and stress. Many people don’t know about one of the oldest herbs in existence valerian. Valerian has many healing qualities … in fact the latin root word valere means to be healthy. Valerian is one of the best herbs for stress … helping with insomnia, restlessness, nervousness, and inducing relaxation. Valerian is a good anti-inflammatory agent helping with swelling, pain, and redness… plus it also calms nerves … and promotes peace of mind.

Vitamin C(anti-inflammatory, natural antihistamine)vitamincinskincare

In addition to being a powerful anti-oxidant and immune booster, some studies have shown that high doses of vitamin c can help reduce sensitivity to allergens and reduce inflammation, mucus production and wheezing.

Water (anti-inflammatory, natural antihistamine)

Drinking plenty of water is one of the most effective natural remedies for inflammation. Water reduces inflammation and promotes cartilage health. To reduce internal inflammation, drink water to carry away waste products. Your body releases histamine in order to stop water loss. If you give your body adequate amounts of water, less histamine will be released.

For a list of references and citations please visit:


I urge you to read through the information on my main website

It’s all free information. Nothing is hidden from you.

This method has worked for me and many others. And it will work for ANYONE that is willing to change their lifestyle – to allow the inflammation in their body to cool down.

How you find the source of your inflammation, that’s your own personal journey. The RLcure website will guide you along, and show you where to look.

When you find out what is causing the inflammation in your body, that is the day you can start waving good-bye to your RLS forever!

I highly recommend that you take a moment to view the TESTIMONIALS from people that this “Absolute Cure” has helped.

These testimonials will hopefully help you to understand that recovery is possible, EVEN FOR YOU … no matter how HORRIBLE your RLS has become!

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Podcast About the Relationship Between Restless Legs Syndrome and Inflammation

bing2_Dr. Hoe Bing Lo hosts a popular science and nutrition podcast that is based in Cairns, Australia.

Dr. Bing has a Bachelor of Medicine and Surgery (M.B.B.S.) and Bachelor of Science Honours (BSc) from the University of Melbourne.

He has written several books on heart health including “Rekindling The Fire: Steps You Must take To Rebuild Your Heart Stronger Than Before Your Attack, One Heart: You Need Your Heart (And It Needs You)”, “What You Don’t Know About Your Heart May Cost You Your Life” and “Renew Your Heart Puzzle: Uncommonly Known But Vitally Important Secrets That Will Keep Your Heart Ticking Strong.”

He has also written many books promoting children’s health including his popular “Maths Club” series. His new “Five Colour Series” is his unique yet simple introduction to the wonderful world of whole food nutrition.

sleepmedjanIn this podcast focusing on Restless Legs, Dr. Bing analyzes a scientific study that was published in 2013 by Dr. Leonard Weinstock (et. al) titled “Restless legs syndrome – Theoretical roles of inflammatory and immune mechanisms.”

Dr. Bing extracts the dense scientific data from the study and presents it in easily understandable terms.

Dr. Bing agrees that inflammation is the root cause, and builds upon the findings of the study by talking about the importance of changing our diet – and gives scientific insights supporting these changes.

You can stream the podcast from the following website:—fire-an

(once you arrive on the website, click on the link that says “Stream” and the podcast will start playing)

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Passionflowers are pretty plus help people with anxiety, stress, insomnia, and RLS. Besides the above-mentioned information about water and dietary changes, which will do more to improve your health than just about anything other than getting good exercise, there are some specific natural substances that will help most RLS sufferers as much or more than the conventional methods above, without unwanted side effects.

I’ve had RLS for many years, although ordinarily it was a minor annoyance. Although, during the past couple of years it got considerably worse, to the point that something had to change. It took a lot of searching to discover the real causes.

In the meantime (while I made the changes, like learning to drink enough pure, clean water and avoiding bad food ingredients), I needed something to help me sleep, while still in process of addressing the root causes of problems the drug companies want to treat with drugs (trust me, you don’t have a deficiency of whatever drug they want to prescribe).

I have found that the following supplements greatly help many people to sleep and to have significant reduction in RLS symptoms. I take the third one listed every night, although I’ve tried the others. They are the only things I’ve taken that were effective for my RLS symptoms besides drinking more water, exercising more, and improving my diet.

Now that I’ve increased my water intake (I don’t drink anything else now), my RLS symptoms are very mild, more like 5% of what they were.

Here are the herbs that help with RLS, stress, anxiety, and insomnia:

(1) Kava kava root extract (often just called “kava”), from a plant that grows on islands in the South Pacific, has been used by Polynesians for thousands of years. It is ignored by mainstream medicine because it’s not nearly as expensive as the prescription drugs, plus it’s not addictive and has no side effects, and they can’t patent it. Instead they try to make kava kava sound unsafe with warnings about liver damage. However, liver damage can only occur if other parts of the plant besides the root are used. Find a trustworthy manufacturer that uses only the root, and there’s no need to worry.

(2) Passion flower extract, from a plant native to North America, was used for centuries by Native Americans, is like kava in that mainstream medicine prefers you use their prescription drugs instead. Passion flower cannot safely be taken at the same time as kava, because both thin the blood some. This also makes both incompatible with some over-the-counter medications like aspirin, ibuprofen, and acetaminophen.

(3) Valerian, from Europe and Asia, was used as long ago as ancient Greece and the Roman Empire. Side effects are almost never seen, and the herb is found by many to work much like benzodiazepines but without the addictive qualities and other problems. Once again, mainstream medicine prefers you not know about it. Valerian also cannot be taken at the same time as kava, due to the fact that both are processed by the liver and overtaxation of the liver could result.

Valerian needs to be taken every day and becomes very effective after two to three weeks. The others can be taken at moments when anxiety, RLS, or whatever needs something. Of the three, I find valerian to be the best.

Note that valerian and passion flower can be taken together.

Since natural supplements are not supported by the government or the medical industry (who are really on the same side), it can be difficult to find information about them. Online research should tell you what the supplements are and aren’t compatible with, what dosages are safe, whether the supplement loses its effectiveness over time, and other needed information. All this is readily available with prescription drugs, but information on supplements including clinical trial information is almost nonexistent or may actually be misleading if the drug companies had a hand in it.

Information can be difficult to find, but it’s very important. The medical industry may actually be harming people by refusing to provide information (or accurate information) about natural supplements, and sticking to their position that everyone just needs the expensive patented prescription drugs (while minimizing, hiding, and denying the drugs’ harmfulness).

For the best website I’ve found that assists with determining interactions of drugs, also including information about many supplements, see


Exercising. I must re-emphasize the importance of overall health, which is adversely affected by insufficient physical activity, use of harmful substances like tobacco and alcohol and many drugs (prescription and illegal), consuming problematic food ingredients, and inadequate intake of pure, clean water (the last of which, as stated, causes dehydration and many “diseases” that result from dehydration).

Other factors critical to health include getting some sun, getting adequate sleep, and overcoming psychological stress.

To learn about food ingredients which are major culprits in causing major health problems, see the links to lenses I’ve made about them, listed below. Learning about these is important because they are very common in foods in nearly every aisle of the grocery store, and they can very much worsen inflammation and many health problems, such as RLS.

Most major food companies generally aim to make you addicted to their products, and to maximize profits at the expense of providing healthy products. The FDA allows nearly every deceptive thing the food companies do, which shows why you need to take personal responsibility and educate yourself, rather than rely on the government to protect you and keep you safe.

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draft_lens20066904module163749090photo_1368827404I ran across this article several months ago on Squidoo. It is written by Jonathan Nielsen from California, who found a solution to his Restless Legs Syndrome through natural means.

The article goes into great detail about commons sense ways to heal your RLS – methods that worked for him, and also worked for me.

It was such a thrill to find someone that had made similar discoveries about the relationship between inflammation and RLS.

Jonathan was kind enough to allow me to repost his article.

The article is fairly long, so I’m going to post it in two parts.


Psychiatric drugs cause RLS in many people. The Wikipedia article on RLS lists some causes, but as we’ll see later in this lens, they leave out the #1 cause. The article lists:

(1) Deficiencies in some substances (iron, dopamine, folate, and magnesium)

(2) Certain auto-immune disorders (such as Sjögren’s syndrome, celiac disease, and rheumatoid arthritis)

(3) “Other associated conditions” (varicose vein or venous reflux, fibromyalgia, sleep apnea, uremia, diabetes, thyroid disease, peripheral neuropathy, hypoglycemia, and Parkinson’s disease)

(4) Medication side effects (side effects of anti-depressants, anti-psychotics, some anti-convulsants, some anti-histamines, benzodiazepines, and antidopaminergic antiemetics)

(5) A genetic inheritance


Wikipedia’s article neglects to mention inflammation as the cause of RLS. That it is caused by inflammation is known and scientific papers have been written on it, although this explanation doesn’t sit well with the medical industry, who like to suppress symptoms with drugs, and never address underlying causes. Note that many conditions listed, such as celiac disease and diabetes, involve massive inflammation.

Since inflammation isn’t mentioned in the Wikipedia article, the main cause of inflammation also isn’t mentioned, which is mild to severe dehydration, caused by not drinking enough pure, plain water.

Dehydration is a problem far more widespread and more serious than many people are aware of, and it is the cause of many common health problems that the medical industry will tell you have no known cause or cure. Miraculously, drinking adequate amounts of water clears these conditions up in many cases, addressing the root cause of the problem.

Medical science tends to focus on the portion of our body that is not water, which is only 30% to 40% of what we are composed of. The importance of what the majority of our body is made of, water, is commonly overlooked. We are typically 60% to 70% water, and thus water intake is critical, and without proper water levels we begin to have serious health problems. We get inflamed when water levels are inadequate.

There are books that are excellent for learning how to minimize inflammation, including dietary advice for avoiding inflammation-promoting foods. I’ll link to some below. However, water intake is the most critical factor.

The mainstream medical industry can’t make much money by telling people to drink water, so instead they invent drugs that don’t address the root causes of the problems. What the drugs do is silence the symptoms that indicate what it is you really need, which is water.

Drugs are pushed because they rake in money and people believe they help because they suppress symptoms. However, since they don’t address the root cause of the problem, health problems don’t go away like they would if the treatment was correct.

Many scientists know about inflammation and the importance of water (and not drinking other stuff that actually makes dehydration worse, like soda, tea, coffee, and alcohol). However, the information is suppressed. You’re supposed to think that drugs are the solution, and that when you hurt you need drugs and not anything natural or inexpensive. Doctors who go against the recommendations of the establishment may be censured or have licenses revoked, even if their advice is helpful to and they said nothing false.

The results are that many people with health problems, including RLS sufferers, will continue to be given treatments that don’t eliminate inflammation and therefore root cause of the problem.

Certain food ingredients are well known for worsening inflammation. Some of the most major ones are sugar, simple carbohydrates (like white flour and white rice), corn syrup, MSG (monosodium glutamate and similar chemicals), and trans fats. Eliminating these is guaranteed to reduce inflammation in your entire system, plus eliminate major causes of serious health problems like diabetes, obesity, migraines, and cancer. However, drinking plenty of pure, plain water is even more important.

Inflammation has also been shown to lower dopamine levels, and low dopamine levels are already accepted as consistent with RLS. The inflammatory food ingredients listed above all increase inflammation, lower dopamine, and can worsen restless legs syndrome, although the main cause is insufficient water intake, which causes chronic dehydration, which causes inflammation and numerous health problems currently described as having “no known cause.”


Water is the best drink of all time. and always will be. I’ve often heard people say that we need eight cups (64 fluid ounces) of water every day. People usually also say that other drinks like juices, milk, sodas, and tea count for these water needs. Even some scientists and nutritionists say that, but it’s not correct.

Caffeine is known to cause more water to be flushed out of your system than how much was in the caffeinated drink itself. Tea, caffeinated sodas, and coffee actually dehydrate you more, rather than helping meet your water needs. Juice is full of sugar, which causes a myriad of problems. Milk provides some protein and calcium, but also has a lot of sugar and growth hormones.

We actually need pure, clean water and not other drinks with calories, sugar, and other things attached. The best guideline for how much pure water to drink? Divide your weight (in pounds) in half, and translate that to ounces. A man who weighs 200 lbs will need 100 oz pure water each day to prevent dehydration. A woman who weighs 150 lbs will need 75 oz pure water each day. These are minimums! It should be higher if you sweat a lot or if you live in a dry climate.

Why is dehydration a big deal? Isn’t dehydration rare? Actually, dehydration is common and it is the biggest cause of inflammation and many common health problems currently recognized as various “diseases,” and usually treated with harmful toxic chemicals (prescription drugs). The drugs usually mask signs of dehydration such as chronic pain, allergies, asthma, migraine headaches, and other symptoms of inadequate water levels in the body. The drugs suppress symptoms but don’t address the root cause of the problem.

PSYCHIATRIC DRUGS WORSEN RESTLESS LEGS SYNDROMEHow-long-do-you-have-to-take-Zoloft-before-it-works2

Anti-depressants like Zoloft can make RLS unbearable. Many of the most major psychiatric drugs, prescribed to sufferers of various mental disorders, significantly aggravate RLS. Look at the list from the article on Wikipedia:

- Anti-depressants, which include the very widely-used SSRIs such as Prozac, Luvox, Paxil, and Zoloft.
– Anti-convulsants, which are commonly used to treat bipolar disorder’s vicious mood swings.
– Benzodiazepines, which are commonly used to treat severe anxiety and panic attacks.
– Anti-psychotics, which are commonly used to treat schizophrenia and mania in bipolar disorder, and they are often used for other purposes as well.

This can be distressing news if you have been taking such medications and you suffer from RLS. The fact that RLS is a side effect of prescription psychiatric drugs, however, should not be a surprise. These drugs have a great many dangerous side effects, many of which are worse than the symptoms of RLS. Here are some examples:

- Benzodiazepines are highly addictive and those who seek to get off them often suffer greatly with withdrawal symptoms.
– Anti-psychotics are notorious for damaging the nervous system, causing weight gain, and causing diabetes.
– Anti-depressants frequently cause sexual dysfunction, have warnings about possibly making suicidal thoughts worse, and also cause many people to gain weight – in addition to being difficult to withdraw from, and rarely performing better than placebo in clinical trials.
– Anti-convulsants can cause problems with weight gain, migraine headaches, and more.

The problem in each of these instances does not lie with the patient, it lies with the drugs. Prescription drugs, besides being incredibly expensive, are often ineffective, and the drug companies don’t like to investigate negative aspects but frequently exaggerate benefits. For many of the conditions these drugs treat, it’s untrue that drugs are the best solution, and it’s also untrue that they treat the underlying problem. All they do is attempt to suppress symptoms, while often causing great harm.

Prescription drugs should actually be a last resort. For anyone perplexed by the idea of treating serious mental illness without drugs, I recommend starting with a booklet titled The Harm Reduction Guide to Coming off Psychiatric Drugs. A link to this item is given below.

Unfortunately, the mainstream medical establishment only cares about making as much profit as possible at the expense of giving people the help they really need. Expensive prescription drugs are pushed with benefits exaggerated and risks minimized, and other treatment options are suppressed, ignored, ridiculed, or slandered.

Next we’ll explore how RLS is currently treated by mainstream medicine, and then we’ll discuss some “alternative” herbal treatments, which are natural and far superior to any bizarre chemical concoction manufactured by the drug companies.

HOW DOCTORS CURRENTLY TRY TO TREAT RLSPuzzled male shrugging wearing lab coat

Benzodiazepines like Xanax can’t both cause and treat RLS. The Wikipedia article highlights the standard treatments given to RLS sufferers. As we’ll see, the treatments seek to address the symptoms but not the underlying cause, which is insufficient water, which causes dehydration, which causes inflammation, which causes RLS and many health problems.

First they suggest moving or shaking one’s legs. This is obvious, and is what RLS sufferers already feel compelled to do. It’s what they want to go away, rather than doing it even more.

Second they suggest iron supplements, although many RLS cases have nothing to do with low iron levels. Sufferers are advised to have iron levels tested and to consult with a physician before taking any iron supplements.

Iron supplementation is of course a good idea if you don’t get enough from your diet. If this helps a RLS sufferer with their symptoms, then great. But for many this will be insufficient.

Third they suggest prescription drugs (also called “pharmaceuticals”). One of these inexplicably is benzodiazepines, which are also on the list of drugs that cause RLS.

In PART TWO we’ll talk about “alternative” (which means not supported by the drug companies) methods for treating RLS.

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Study: Herbal Mixture Provides Significant Results for Children with RLS

ImageIn the following study from 2005, researchers created a mixture of several healing ingredients and produced a syrup which the children with RLS took orally.

Out of the 14 ingredients in the mixture, 13 of them had ANTI-INFLAMMATORY properties (references can be found for each by following the link at the end of this post). The only ingredient that didn’t have anti-inflammatory properities was Long Gu (Dragon’s Bone) which is “ground bone” – a sedative to reduce stress and calm the mind.


“Fifty cases of child restless legs syndrome treated with the integrated method of Chinese Herbal drugs.”
Wang W. and Fan H. J Tradit Chin Med. 2005 Dec;25(4):276-7.

Fifty cases of child restless syndrome were treated with oral administration of Chinese traditional herbal drugs plus auricular-plaster therapy from December 1998 to November 2001, and another 47 cases were treated with oral administration of methylphenidate as controls


For patients in the treatment group the ingredients of formula were prescribed as below:  Image

Fu-Ling (Poria cocos) 40g
Shan Yao / Radix Dioscoreae (Chinese Yam Root) 40g
Radix Rehmanniae Praeparata 30g
Shan Zhu Yu (Fructus Corni) 30g
Shi Chang Pu (Rhizoma Acori Tatarinowii) 45g
Yuan Zhi / Radix Polygalae (Chinese Senega Root) 30g
Bai Ji Li (Fructus Tribuli) 30g
Long Gu (Dragon’s Bone) 60g
Mu Li (Oyster shell) 60g
Jiang Can / Bombyx Batryticatus (Silkworm) 30g
Gou Teng (cat’s claw) 30g
Yi Zhi Ren (Chinese Ginger) 30g
Da Zao (Jujube Fruit) 30g
Gan Cao / Radix Glycyrrhizae (Licorice Root) 25g   

They were made into 250 ml of syrup in the pharmaceutics department of this hospital.

The syrup was orally administered to the patients under 9 years in a dose of 25 ml, three times daily, and to the patients over 9 years in a dose of 40 ml, three times daily.


Of the 50 cases in the treatment group, 21 cases were markedly effective, 26 cases effective, and 3 cases ineffective, with a total effective rate of 94%. Among the 47 cases in the control group, 15 cases were markedly effective, 17 cases effective, and 15 cases ineffective, with a total effective rate of 68.09%. The difference in total effective rate between the two groups was statistically very significant (P<0.01).


The results showed that the therapeutic effect of the treatment group was significantly superior to that of the control group

For details on the anti-inflamatory properties of the ingredients please visit:

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Successful Treatment of Restless Legs Syndrome with the Herbal Prescription “Yokukansan.”

ImageYokukansan, also known as TJ-54, is composed of SEVEN herbs; Angelica acutiloba, Atractylodes lancea, Bupleurum falcatum, Poria cocos, Glycyrrhiza uralensis, Cnidium officinale and Uncaria rhynchophylla.

Yokukansan is used to treat insomnia and irritability as well as screaming attacks, sleep tremors and hypnic myoclonia, and neurological disorders which include dementia and Alzheimer’s disease.

Not only has Yokukansan proven in studies to have STRONG anti-inflammatory qualities, but EACH of the seven herbs that make up Yokukansan have anti-inflammatory qualities (references to these studies are below).

In 2010 a study showed that Yokukansan was beneficial in relieving RLS in all 3 test subjects.

In their conclusion, the scientists don’t mention that it was due to the anti-inflammatory properties of Yokukansan that brought on the relief in all 3 subjects.

However, it is just a matter of time before this case becomes another obvious example of the undeniable LINK between inflammation and RLS.

“Successful treatment of restless legs syndrome with the herbal prescription Yokukansan.”

Hideto Shinno, Mami Yamanaka, Ichiro Ishikawa, Sonoko Danjo, Yasushi Inami, Jun Horiguchi and Yu Nakamura. Progress in Neuro-Psychopharmacology and Biological Psychiatry. Volume 34, Issue 1, 1 February 2010, Pages 252–253.


RLS improved in ALL 3 cases after the addition of Yokukansan. We speculate that actions on GABAergic, serotonergic and dopaminergic systems might account for some of the therapeutic effects of KS in the present cases. YKS, therefre, appears to be useful in RLS treatment.


“Use of Yokukansan (TJ-54) in the treatment of neurological disorders: A review.”
S. de Caires, V. Steenkamp. Department of Pharmacology, Faculty of Health Sciences, University of Pretoria

“Ameliorative effects of yokukansan on behavioral deficits in a gerbil model of global cerebral ischemia.”
Liu Y et al. Brain Res. 2014 Jan 16;1543:300-7. doi: 10.1016/j.brainres.2013.11.015. Epub 2013 Nov 19.

“Yokukansan promotes hippocampal neurogenesis associated with the suppression of activated microglia in Gunn rat.”
Motohide Furuya et al. Journal of Neuroinflammation 2013, 10:145 doi:10.1186/1742-2094-10-145

“Effects of Angelica acutiloba on mast cell-mediated allergic reactions in vitro and in vivo.”
Kyungjin Lee et al. Immunopharmacology and Immunotoxicology, August 2012, Vol. 34, No. 4 : Pages 571-577

“Further Phenols and Polyacetylenes from the Rhizomes of Atractylodes lancea and their Anti-Inflammatory Activity.”
M. Resch et al. Planta Med 2001; 67(5): 437-442. DOI: 10.1055/s-2001-15817

Bupleurum (Bupleurum falcatum)

Assessment of anti-inflammatory activity of Poria cocos in sodium lauryl sulphate-induced irritant contact dermatitis.
Fuchs SM et al. Skin Res Technol. 2006 Nov;12(4):223-7.

“Antioxidant and Antiinflammatory Activities of Licorice Root (Glycyrrhiza uralensis): Aroma Extract.”
Aki Tanaka and Takayuki Shibamoto. Chapter 20, pp 229–237. Chapter DOI: 10.1021/bk-2008-0993.ch020. ACS Symposium Series, Vol. 993.

“Components of rhizome extract of Cnidium officinale Makino and their in vitro biological effects.”
Bae KE et al. Molecules. 2011 Oct 21;16(10):8833-47. doi: 10.3390/molecules16108833.

“Uncaria rhynchophylla inhibits the production of nitric oxide and interleukin-1ß through blocking nuclear factor ?B, Akt, and mitogen-activated protein kinase activation in macrophages.”
Kim JH et al. J Med Food. 2010 Oct;13(5):1133-40. doi: 10.1089/jmf.2010.1128.

You can read the full study here:

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Studies Show that Stress Increases Inflammation Levels

ImageMy last post featured studies on how INSOMNIA increases inflammation. This post will examine how STRESS increases inflammation.

If you’ve read some of the posts on this page, or have visited my website – you’ll know that I FIRMLY believe that inflammation is the CAUSE of RLS. Science is now confirming this.

What this means is that insomnia and stress are issues that must somehow be dealt with in order to help your suffering to come to an end. The MORE the inflammation in your body increases, the MORE your legs will act up.

Prescribed drugs are not the answer. Whatever lies beneath the surface and is causing your stress cannot be dissolved with a drug. That requires change through meditation, relaxation exercises, therapy etc.

This post provides scientific evidence that stress increases inflammation levels.

The information you’ll read below are short excerpts from articles talking about the studies. To view the full studies please visit:stressedcake

“Chronic Stress Changes Immune Cell Genes, Leading To Inflammation” Huffington Post, July 7, 2013

A new study provides a better understanding of why chronic stress leads to high levels of inflammation in the body.

Researchers found that chronic stress changes gene activity of immune cells before they enter the bloodstream so that they’re ready to fight infection or trauma — even when there is no infection or trauma to fight. This then leads to increased inflammation.

“Dwelling on stressful events can increase inflammation in the body, study finds.” Ohio University Office of Research Communications. March 13, 2013.

Dwelling on negative events can increase levels of inflammation in the body, a new Ohio University study finds.

Researchers discovered that when study participants were asked to ruminate on a stressful incident, their levels of C-reactive protein, a marker of tissue inflammation, rose. The study is the first to directly measure this effect in the body.

Image“How Stress Influences Disease: Carnegie Mellon Study Reveals Inflammation as the Culprit.” Carnegie Mellon News (April 2012).

A research team led by Carnegie Mellon University’s Sheldon Cohen has found that chronic psychological stress is associated with the body losing its ability to regulate the inflammatory response. Published in the Proceedings of the National Academy of Sciences, the research shows for the first time that the effects of psychological stress on the body’s ability to regulate inflammation can promote the development and progression of disease.

“Inflammation is partly regulated by the hormone cortisol and when cortisol is not allowed to serve this function, inflammation can get out of control,” said Cohen, the Robert E. Doherty Professor of Psychology within CMU’s Dietrich College of Humanities and Social Sciences.

Cohen argued that prolonged stress alters the effectiveness of cortisol to regulate the inflammatory response because it decreases tissue sensitivity to the hormone. Specifically, immune cells become insensitive to cortisol’s regulatory effect. In turn, runaway inflammation is thought to promote the development and progression of many diseases.

“When under stress, cells of the immune system are unable to respond to hormonal control, and consequently, produce levels of inflammation that promote disease. Because inflammation plays a role in many diseases such as cardiovascular, asthma and autoimmune disorders, this model suggests why stress impacts them as well.”

“Brain pathways linking social stress and inflammation identified.” from Science Daily. Aug. 2010.

A new studys show that individuals who exhibit greater neural sensitivity to social rejection also exhibit greater increases in inflammatory activity to social stress.2stress

Their results showed that individuals who exhibited greater neural activity in the dorsal anterior cingulate cortex and anterior insula during social rejection in the brain scanner also exhibited greater increases in inflammatory activity when exposed to acute social stress in the lab.

“This is further evidence of how closely our mind and body are connected,” Slavich said. “We have known for a long time that social stress can ‘get under the skin’ to increase risk for disease, but it’s been unclear exactly how these effects occur. To our knowledge, this study is the first to identify the neurocognitive pathways that might be involved in inflammatory responses to acute social stress.”


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Studies Show that Insomnia Increases Inflammation Levels

ImageYou’re lying awake in bed at 4 am. – it’s another sleepless night. Your legs are twitching and pulsating, your mind is racing aimlessly with blurred abstract nonsense and the giant purple bags under your eyes continue to darken and grow larger.

Yes, we’ve all been there.

The last thing you need to hear is that your STRESS and LACK OF SLEEP are actually making the problem WORSE!

But, it’s the truth.

And now that you know this, you can do something about it.

As the powerful influence of inflammation continues to move to the forefront of the media, more and more studies are being done to find out just how widespread its effects are. This includes studies I’ll present to you on this website showing that both stress and insomnia increase inflammation levels.

This post provides scientific evidence that insomnia increases inflammation levels. My next post will focus on how stress increases inflammation levels.

The information you’ll read below are short excerpts from the studies. To view the full studies please visit:

Image“Sleep Loss and Inflammation.”
Janet M. Mullington et al. Best Pract Res Clin Endocrinol Metab. Oct 2010; 24(5): 775–784.


Controlled, experimental studies on the effects of acute sleep loss in humans have shown that mediators of inflammation are altered by sleep loss.  


“Sleep duration and biomarkers of inflammation.”
Patel SR et al. Sleep. 2009 Feb;32(2):200-4.


Extremes of sleep duration have been associated with adverse health outcomes. The mechanism is unclear but may be related to increased inflammation. We sought to assess the association between sleep duration and inflammatory biomarkers.


Increases in habitual sleep durations are associated with elevations in CRP and IL-6 while reduced PSG sleep duration is associated with elevated TNFa levels. Activation of pro-inflammatory pathways may represent a mechanism by which extreme sleep habits affect health.

Image“Sleep Loss Activates Cellular Inflammatory Signaling”
Michael R. Irwin et al. Biol Psychiatry. 2008 Sep 15;64(6):538-40.


Accumulating evidence suggests that sleep disturbance is associated with inflammation and related disorders including cardiovascular disease, arthritis, and diabetes mellitus. This study was undertaken to test the effects of sleep loss on activation of nuclear factor (NF)-kappaB, a transcription factor that serves a critical role in the inflammatory signaling cascade.


“Chronic Insomnia and Stress System.”
Maria Basta, M.D. et al. Sleep Med Clin. Jun 2007; 2(2): 279–291.


In insomnia, which is a very common sleep disorder, objective sleep measures, EEG activity, physiologic findings, HPA axis activity and inflammation markers suggest that it is not a state of sleep loss, but a disorder of hyperarousal present both during the night and the daytime.

The finding that pro-inflammatory cytokines’ IL-6 and TNFa daytime secretion is elevated in insomniacs, considering their role in subjective complaints of fatigue and poor performance, may lead to novel approaches to treat insomnia.


“The effects of 40 hours of total sleep deprivation on inflammatory markers in healthy young adults.”
Frey DJ et al. Brain Behav Immun. 2007 Nov;21(8):1050-7.


Inflammatory cytokines are released in response to stress, tissue damage, and infection. Acutely, this response is adaptive; however, chronic elevation of inflammatory proteins can contribute to health problems including cardiovascular, endocrine, mood, and sleep disorders.

Our findings suggest that one night of sleep loss triggers a stress response that includes stimulation of both pro- and anti-inflammatory proteins in the healthy young subjects tested under our experimental conditions.


“Effect of sleep loss on C-reactive protein, an inflammatory marker of cardiovascular risk.”Image
Meier-Ewert HK et al. J Am Coll Cardiol. 2004 Feb 18;43(4):678-83.


Both acute total and short-term partial sleep deprivation resulted in elevated high-sensitivity CRP concentrations, a stable marker of inflammation that has been shown to be predictive of cardiovascular morbidity. We propose that sleep loss may be one of the ways that inflammatory processes are activated and contribute to the association of sleep complaints, short sleep duration, and cardiovascular morbidity observed in epidemiologic surveys.


“Sleep Restriction Increases the Risk of Developing Cardiovascular Diseases by Augmenting Proinflammatory Responses through IL-17 and CRP.”
Wessel M. A. et al. PLoS One. 2009;4(2):e4589. doi: 10.1371/journal.pone.0004589. Epub 2009 Feb 25.


Sleep restriction, leading to deprivation of sleep, is common in modern 24-h societies and is associated with the development of health problems including cardiovascular diseases. Our objective was to investigate the immunological effects of prolonged sleep restriction and subsequent recovery sleep, by simulating a working week and following recovery weekend in a laboratory environment.


5 nights of sleep restriction increased lymphocyte activation and the production of proinflammatory cytokines including IL-1beta IL-6 and IL-17; they remained elevated after 2 nights of recovery sleep, accompanied by increased heart rate and serum CRP, 2 important risk factors for cardiovascular diseases. Therefore, long-term sleep restriction may lead to persistent changes in the immune system and the increased production of IL-17 together with CRP may increase the risk of developing cardiovascular diseases.

For tips on putting an end to your sleepless nights, please visit these pages:


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