Posts Tagged anti-inflammatory

Participants sought for restless legs study

Individuals with restless or unpleasant feelings in their legs at night or at rest, that are relieved by movement are needed. We are studying the possible benefits of yoga versus an educational film program for reducing symptoms of restless legs syndrome. Participants will attend up to two classes per week in Morgantown for 12 weeks. The study also involves two visits to WVU to complete questionnaires. Compensation is $150 upon completion of this research study. IRB approval on file (1505699758)

For additional information, contact:

  • WVU School of Public Health, Department of Epidemiology
  • Caitlin Montgomery, MPH
  • 304.293.2082, cmontgo2@mix.wvu.edu

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“The Common Causes of Restless Legs Syndrome” by Dr. Aaron Ernst

AskDrErnstRestless legs syndrome is a seemingly unique condition and the cause is often difficult to pinpoint.

Few things are more frustrating than lying in bed at night, exhausted, but not being able to fall asleep because of an uncontrollable urge to move your legs. It seems so strange, doesn’t it? This phenomenon, known as restless legs syndrome (RLS), affects between 4% and 29% of adults in Western populations, and is a major contributor to sleep loss.

Pinpointing the cause of RLS has been an active research topic for years, but the condition is still not fully understood. The symptoms have been convincingly linked to impaired dopamine function in the brain, but the cause of this dysfunction is still being explored. Here are my top causes:

1. Systemic Inflammation & Immune Dysregulation (Subluxation)

One review paper published in 2012 investigated health conditions that were reported to Acute pain in a woman hand. Isolation on a white backgroundcause or exacerbate RLS symptoms, and found that 95% of the health conditions that are associated with RLS have an inflammation or immune component. As further evidence, an elevated blood level of C-reactive protein (a marker of systemic inflammation) has been associated with increased RLS severity.

Researchers have proposed three potential mechanisms to explain the association between RLS and inflammatory or autoimmune states: direct autoimmune attack on the nervous system; genetic factors that could predispose an individual to RLS and be triggered by inflammation or autoimmunity; and vitamin D deficiency caused by inflammation, which I’ll talk more about below.

What to do: If your RLS is a symptom of underlying systemic inflammation or immune dysregulation, the goal should be to find and treat the root cause & reduce the stressors to the central nerve system and spine. Often we see the issue target to L5/S1 regions.

2. Small Intestinal Bacterial Overgrowth (SIBO) and IBS

A recent study found that 69% of RLS patients also had SIBO, compared with only 28% of control subjects. They also found that 28% of RLS patients had IBS, compared to only 4% of controls. And according to the 2012 review I mentioned above 32% of the health conditions associated with RLS are also associated with SIBO. As I’ve mentioned many times in the past neurological interference & gut infections are often the culprit—even if you don’t have noticeable symptoms—its worth getting your gut tested.

What to do: If you have RLS and suspect you may have SIBO or a gut issue its best to get tested to find our what is going on in there. Generally speaking, the intestines need to be flushed or cleansed then re-inoculated with healthy living strains of bacteria. Your typical probiotic won’t be able to do that. Overall the best approach is to follow a ketosis diet with bone broth until symptoms subside (and your SIBO tests are normal), and then gradually re-introduce fermented foods and probiotics.

3. Vitamin D Deficiency

One of the most-researched theories about the cause of restless legs syndrome is impaired dopamine signaling, which has led to the conventional treatment of RLS by dopamine agonists (i.e. chemicals that can bind to and activate dopamine receptors). Unfortunately, these treatments can become less effective over time, and can even result in a worsening of symptoms.

vitaminThis is where vitamin D comes into play. The role of vitamin D in dopamine signaling is only beginning to be investigated, but some evidence indicates that vitamin D could play an important role by increasing levels of dopamine and its metabolites in the brain, as well as protecting dopamine-associated neurons from toxins.

RLS has been associated with vitamin D deficiency in several studies, and disease severity has been inversely correlated with vitamin D levels. One study has also found that vitamin D supplementation improved the severity of RLS symptoms.

What to do: If you have RLS, one of the easiest first steps you can take is to get your vitamin D levels tested. A good range to shoot for is typically between 40-60 ng/mL. If you have an autoimmune disease or another chronic health condition, optimal levels are between 60-80 ng/mL. One way to supplement vitamin D is through taking it directly. And of course, you should get regular sun exposure.

We’re still learning more and more about this syndrome, and hopefully we’ll come to some truly concrete answers soon enough. But as is so often the case, watching your nutrition and lifestyle goes a really long way in taking care of these sorts of issues.

This information originally appeared on the “Ask Dr. Ernst” website.
https://askdrernst.com/common-causes-restless-leg-syndrome

Dr. Aaron Ernst completed his undergraduate education in pre-medicine/biology at Messiah University in Grantham, PA. As a first generation holistic practitioner, he began his career with a Doctorate in Chiropractic from Logan College of Chiropractic in Chesterfield, MO.  While in Missouri, Dr. Aaron began helping patients rebuild their health in a Maximized Living Health center, which was the largest wellness clinic in Missouri. His experience has led him to spend countless hours studying and researching to create procedures and protocols to rebuild health naturally. Dr. Aaron has traveled all over North America, Europe and Africa teaching the principles of Maximized Living and educating all generations on gaining victory over disease naturally.

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Another Scientific Link Between Restless Legs Syndrome and Inflammation

chronic-illness-46-638Below is an excerpt from an article titled “Inflammation and Pain Management with Magnesium” by Dr. Mark Sircus, Ac., OMD, DM (P), December 8, 2009

“According to the National Sleep Foundation approximately 70 million people in the United States are affected with sleeping disorders. Approximately 12 million Americans have Restless Legs Syndrome, a sleep and movement disorder characterized by unpleasant (tingling, crawling, creeping and/or pulling) feelings in the legs, which cause an urge to move in order to relieve the symptoms.  

‘People with poor quality sleep or sleep deprivation exhibit increased levels of interleukin-6 (IL6), the chemical that causes inflammation throughout the body’ (Redwine et al. 2000).”

The above excerpt is a short but effective overview of the way that Restless Legs Syndrome feeds off itself; ever increasing the stranglehold it has over each individual.

The original RLS-causing inflammation in your body could have been created because of a number of issues. It’s  likely that diet is involved, but there are many other possible contributors such as lifestyle, environment & toxins, alcohol consumption, stress, pregnancy, aging etc.

Once the inflammation inside you reaches a level that causes your legs to start tingling … a whole new (ugly) cycle begins!

The lack of sleep you begin to experience because of your wonky legs AS WELL AS the stress of the increasing frustration BOTH raise the existing inflammation level inside of you.

And, of course, as time goes on, it just gets worse. It’s an ugly, ugly debilitating cycle.

Your sleep gets worse, the inflammation increases. Your stress gets higher, the inflammation increases. Your anger deepens, the inflammation increases.

Yes, all the while, the RLS-causing inflammation inside of you increases, raising your inflammation and RLS to new levels.

THE SOLUTION:

Healing RLS requires a multi-pronged attack. You can’t just take a pill and wish it all away.  Taking a prescribed medication expecting it to rid your RLS is like closing the door to a room that is on fire expecting the fire to die out.

The inflammation inside of you is going to continue to increase and manifest in other ways. (I explain how RLS is actually a warning signal from your body, on my website http://www.rlcure.com).

To rid yourself of RLS you need to:

1. Put a cork in where the inflammation is flowing into your life.

This means, first off, change your diet! Get the sugar, trans & saturated fats, gluten, alcinflammatoryfoodsohol, refined carbohydrates and MSG out of your life, as best you can. Give your body a chance to heal. It doesn’t have to be forever, just give it some breathing room to heal itself.

It also means that you need to learn to calm down.

Meditation, relaxation exercises and yoga have all been clinically proven to lower inflammation levels.

I still believe that no one is beyond help when it comes to RLS and inflammation. Regardless of how hopeless you think your situation is, if you’re willing to make necessary sacrifices and put in the work, you can be healed.

For some helpful tips on natural ways to put out the fire that’s raging inside your body, please visit my website http://www.rlcure.com

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“A LITTLE-KNOWN CAUSE OF RESTLESS LEGS SYNDROME” by Dr. Della Parker

Dr. Della Parker3Systemic Inflammation and Immune Dysregulation
 
Restless legs syndrome has been associated with numerous conditions involving systemic inflammation and immune dysregulation. One review paper published in 2012 investigated health conditions that were reported to cause or exacerbate RLS symptoms, and found that 95% of the 38 different health conditions that were strongly associated with RLS have an inflammation or immune component. These conditions include Parkinson’s disease, multiple sclerosis, ADHD, Alzheimer’s disease, Celiac disease, Crohn’s disease, rheumatoid arthritis, sleep apnea, diabetes, and depression.
 
As further evidence, an elevated blood level of C-reactive protein (a marker of systemic inflammation) has been associated with increased RLS severity. (5) A small crossover trial found that a hydrocortisone infusion, which reduces systemic inflammation, reduced RLS symptoms.
 
Researchers have proposed three potential mechanisms to explain the association between RLS and inflammatory or autoimmune states: direct autoimmune attack on the nervous system; genetic factors that could predispose an individual to RLS and be triggered by inflammation or autoimmunity; and iron deficiency caused by inflammation, which I’ll talk more about below.
 
What to do: If your RLS is a symptom of underlying systemic inflammation or immune dysregulation, the goal should be to find and treat the root cause. As I’ve mentioned many times in the past, gut infections are often the culprit—even if you don’t have noticeable digestive symptoms—so get your gut tested.
 
If you already have a diagnosed inflammatory or immune condition such as those I mentioned above, the best first step you can take is to adopt a “low-inflammatory” diet and lifestyle. This means eating a nutrient-rich, low-toxin diet based on whole foods; getting enough sleep every night; prioritizing stress management; and incorporating regular movement into your day.
 
You can also check out the bonus chapter about autoimmune disease from my book, as well as explore other information on my site about reversing autoimmune disease, the autoimmune protocol, the role of the microbiome, and alternative therapies such as LDN.
 
You can read the entire article here:
Dr. Della Parker, a naturopathic doctor, was born and raised in Portland, Oregon. She graduated from Portland State University with a Bachelor of Science. She then went on to graduate from the National College of Naturopathic Medicine, also in Portland, Oregon. Dr. Della has struggled with health problems throughout her life. Severe asthma and eczema as a child led her down a path of chronic steroid use, which led to many other health problems. It wasn’t until she took a job as a receptionist at a holistic health clinic that she realized how health care could be different. Making basic changes to diet and lifestyle as well as being treated with the holistic model of health, she was able to regain and take control of her health. This experience put her on the path of becoming a Naturopathic Physician. Most conventional doctors use a “cookbook” approach to treating patients. They use protocols to treat diseases while disregarding the host. This takes the functioning of the individual’s body out of the equation. Dr. Della rejects this idea and instead uses a holistic approach to treatments. Using the holistic model means that the whole person is addressed. For example, ten different patients could present with high cholesterol. They each may receive a different treatment recommendation based on the functioning of their whole body. http://www.drdellaparker.com
 

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A Japanese Study Has Found an Association Between RESTLESS LEGS SYNDROME and INFLAMMATION

sleepcoverDr. Terumi Higuchi of the Department of Nephrology, Keiai Hospital, Tokyo Japan, headed a recent study to determine if there was an association between RLS, oxidative stress and inflammation in patients undergoing hemodialysis.

The results of the study were published in the August 2015 edition of the “Sleep Medicine Journal” (Volume 16, Issue 8, Pages 941–948).

The study was called “Association of restless legs syndrome with oxidative stress and inflammation in patients undergoing hemodialysis”

In the HIGHLIGHT section of the study, Dr. Higuchi states that “Restless legs syndrome was associated with oxidative stress and inflammation.”

You can read more details about the study here:
http://www.sleep-journal.com/article/S1389-9457%2815%2900746-7/abstract?cc=y=

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A Wayne State Study is Testing the Effects of Tocotrienols (from Palm Oil) on Restless Legs Syndrome

palm-oil-fruitINTRODUCTION:

For many years I’ve waited with great hope that some day there would be a study to test the effectiveness of a natural anti-inflammatory on patients with RLS. Today, I’m extremely excited to announce that dream is coming true!

The article below gives details on a study that is underway that is going to test the effect of powerful anti-inflammatories called “Tocotrienols” on End-Stage Renal Disease (Kidney Disease) and at the same time they are going to measure its effect on Restless Legs Syndrome.

After the article I have posted some details on what Tocotrienols are, and how their anti-inflammatory benefits have tested in regard to other medical conditions.

THE STUDY:

“A team of researchers led by Pramod Khosla, Ph.D., associate professor of nutrition and food science in the College of Liberal Arts and Sciences at Wayne State University, will study the effects of a daily supplement of a Tocotrienol-rich fraction from palm oil to see if it improves dyslipidemia, a disorder of lipoprotein metabolism that may be manifested by a decrease in the “good” high-density lipoprotein (HDL) cholesterol in patients with ESRD who are on hemodialysis. Tocotrienols are a form of Vitamin E and have been shown in recent years to have diverse health effects. In addition, Khosla’s team will explore the impact on symptoms such as inflammation and symptoms related to Restless Leg Syndrome in the same cohort of patients.

Khosla believes that the supplement will also act as an anti-inflammatory and antioxidant nutrient, leading to improved nutritional status, lipid profiles, and inflammatory and oxidative stress markers in the ESRD patients.

The three-year study, funded by a $2.4 million grant from the Malaysian Palm Oil Board, a premier government agency of Malaysia, will take place in multiple dialysis centers in the United States and Malaysia. The cross-collaboration will allow the investigators to evaluate differences in dietary patterns of 800 dialysis patients in the two countries. With the patient pool in Michigan of predominantly African Americans and Caucasians and the Malaysian cohort comprised of three distinct ethnicities – Malays, Chinese and Indians – the investigators hope to shed light on possible genetic and metabolic differences in the dialysis populations. Additionally, as a significant proportion of dialysis patients suffer from Restless Legs Syndrome — an unpleasant tingling or cramping sensation that impacts the quality of life — the investigators hope to shed some light on the underlying causes for the condition.redpalmoil

“End-stage renal disease patients undergoing chronic hemodialysis experience a higher risk of complications such as cardiovascular disease, dyslipidemia, Restless Leg Syndrome, insomnia and other health issues,” said Khosla. “In this study, we hope to see significant improvements in various biomarkers that should help decrease some of these complications.”

Dr. James Sondheimer, associate professor of medicine and chief of the Division of Nephrology and Hypertension at WSU stated “We hope to gain a better understanding of how tocotrienols, as substances with antioxidant and anti-inflammatory effects, affect clinical outcomes as well as metabolic parameters.”

http://www.eurekalert.org/pub_releases/2015-07/wsu–wss071315.php

ABOUT TOCOTRIENOLS:

Tocotrienols are members of the vitamin E family. An essential nutrient for the body, vitamin E is made up of four tocopherols (alpha, beta, gamma and delta). Tocotrienols are potent gene regulators and modulators of many enzymes involved in human health, helping to quash the inflammation, glycation, and other processes that contribute to age-related diseases. Tocotrienols are increasingly being recognized for their potential roles in protecting against cancer, heart disease, stroke, diabetes, liver disease, neurodegenerative diseases, and even osteoporosis.

Tocotrienols are natural compounds found in select vegetable oils, including rice bran oil and palm oil, wheat germ, barley, saw palmetto, anatto, and certain other types of seeds, nuts, grains, and the oils derived from them. This variant of vitamin E typically only occurs at very low levels in nature.

In studies, Tocotrienols reduced plasma levels of C-reactive protein (CRP), which is both a marker of and a cause in the inflammatory response that damages heart and blood vessels. They reduce other inflammatory mediators such as cytokines.

Tocotrienols are potent antioxidants, which appear to reduce the oxidant-induced inflammation that contributes to bone loss.

553f63ad3015dedf22d0017954155678Tocotrienols given to mice with pancreatic cancer significantly improved their survival. Only 10% of animals in the control group survived for the study period while 70% of those taking tocotrienols survived!1 Pancreatic cancer is a particularly fast-moving and lethal form of cancer, and this study presents a promising new treatment option. Beyond cancer, research is showing that tocotrienols have a place in reducing important risk factors for some of the most lethal chronic diseases. For example, tocotrienols have been found to promote new artery formation after a stroke, lower homocysteine levels, improve insulin sensitivity, protect vital brain circuitry, and even prevent bone loss.

In a study using rabbits, tocotrienol supplementation, after a high-fat diet, significantly lowered a host of markers of both inflammation and heart muscle damage.

Through studies, tocotrienols have been closely linked to neuroprotection through their potent antioxidant properties, as well as their ability to redirect the production of inflammatory molecules to non- or even anti-inflammatory actions.

SOURCES:

“Tocotrienol” Wikipedia  en.wikipedia.org/wiki/Tocotrienol
“The Little-Known Benefits Of Tocotrienols” by Thomas Rosenthal http://www.lifeextension.com/magazine/2014/8/the-little-known-benefits-of-tocotrienols/page-01
Prasad K. Tocotrienols and cardiovascular health. Curr Pharm Des. 2011;17(21):2147-54.
Das S, Mukherjee S, Lekli I, et al. Tocotrienols confer resistance to ischemia in hypercholesterolemic hearts: insight with genomics. Mol Cell Biochem. 2012 Jan;360(1-2):35-45. Nazrun AS, Norazlina M, Norliza M, Nirwana SI. The anti-inflammatory role of vitamin e in prevention of osteoporosis. Adv Pharmacol Sci. 2012;2012:142702.
Nizar AM, Nazrun AS, Norazlina M, Norliza M, Ima Nirwana S. Low dose of tocotrienols protects osteoblasts against oxidative stress. Clin Ter. 2011;162(6):533-8.
Muhammad N, Luke DA, Shuid AN, Mohamed N, Soelaiman IN. Two different isomers of vitamin e prevent bone loss in postmenopausal osteoporosis rat model. Evid Based Complement Alternat Med. 2012;2012:161527.
Tiwari V, Kuhad A, Bishnoi M, Chopra K. Chronic treatment with tocotrienol, an isoform of vitamin E, prevents intracerebroventricular streptozotocin-induced cognitive impairment and oxidative-nitrosative stress in rats. Pharmacol Biochem Behav. 2009 Aug;93(2):183-9.
Kaileh M , Sen R. Role of NF-kappaB in the anti-inflammatory effects of tocotrienols. J Am Coll Nutr. 2010 Jun;29(3 Suppl):334S-339S.

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The Link Between Stroke, Restless Legs Syndrome and Inflammation

11111ast-stroke-posterYou may have read about a new study that’s getting a lot of press. The study shows that severe Restless Legs Syndrome is linked to increased stroke.

Here is an excerpt about the study from an article written by Megan Brooks of MedScape.

“More severe restless legs syndrome (RLS) is associated with an increased risk for stroke, particularly ischemic stroke, a new analysis of data from the Nurses’ Health Study II suggests.

“We were surprised at the importance of taking into account RLS severity — it was only severe RLS, not milder RLS, that was associated with increased risk of stroke,” principal investigator Xiang Gao, MD, PhD, director, Nutritional Epidemiology Lab, Department of Nutritional Sciences, Pennsylvania State University in University Park, said in a statement.”

You can read the full article here:
http://www.medscape.com/viewarticle/846486

This is not actually news. There was a study published in 2008 that demonstrated a powerful link between Stroke and Restless Legs Syndrome.

“A new US study has found that people with restless legs syndrome (RLS) have double the risk of stroke and heart disease compared to people without RLS. The study is the work of Dr John W Winkelman, of Harvard Medical School in Boston, Massachusetts, and colleagues, and is published in the Janaury 1st 2008 issue of the journal Neurology.” from “Restless Legs Linked To Increased Stroke And Heart Disease Risk” by Catharine Paddock, Medical News Today
http://www.medicalnewstoday.com/articles/92849.php

As is the case with many other diseases and conditions, logic dictates that inflammation is the common link and points to the fact that RLS is an inflammatory condition and can therefore be treated if an anti-inflammatory protocol is set into motion.

In other words, stop eating crap that messes up your body.strokex216

Here are some quotes about the link between inflammation and stroke (for more information about the link between RLS and inflammation visit http://www.RLcure.com).

“Inflammation is an all encompassing term for a complex process that entails multiple cellular, hormonal and biochemical alterations that are both systemic and organ-specific. A panalopy of acute and chronic infections as well as many exogenous and intrinsic sources of inflammation is associated with an increased risk for ischemic stroke.”  from “Inflammation and Stroke” by Bruce M. Coull, Arizona Health Science Center, University of Arizona, Department of Neurology

“Evidence continues to accumulate to suggest important roles for inflammation and genetic factors in the process of atherosclerosis and specifically in stroke. According to the current paradigm, atherosclerosis is not a bland cholesterol storage disease, as previously thought, but a dynamic, chronic, inflammatory condition due to a response to endothelial injury.”  from “Genetic and Inflammatory Mechanisms in Stroke” by Sally Sultan, MD, Columbia University Medical Center

“Recent work in the area of stroke and brain ischemia has demonstrated the significance of the inflammatory response accompanying necrotic brain injury. Acutely, this response appears to contribute to ischemic pathology, and anti-inflammatory strategies have become popular.”  from the study: “The Inflammatory Response in Stroke” by Qing Wang, MD et al. J Neuroimmunol. 2007 May 14.

“Exactly how inflammation plays a role in heart attack and stroke remains a topic of ongoing research. It appears that the inciting event in many heart attacks and some forms of stroke is buildup of fatty, cholesterol-rich plaque in blood vessels.”
Deepak Bhatt, M.D, Chief of Cardiology for the VA Boston Healthcare System (from “Inflammation and Heart Disease” The American Heart Association)

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